The invention relates to a wireless radio frequency module serial communication method used for a remote control device. The wireless radio frequency module serial communication method comprises connection confirmation, including, sending a connection request instruction frame to a target slave machine by a host, and replying to confirm a connection instruction frame to finish connection confirmation of the host and the target slave machine after the target slave machine receives the connection request instruction frame; data transmission, including, after connection confirmation, sending a data frame to the slave machine by the host, and receiving the data frame by the slave machine; and state checking, including, when the number of the target slave machine is 1 and after a set number ofthe target frames are set at each time, performing connection confirmation for the host and the slave machine by the host. In comparison with the prior art, when the number of the target slave machineis 1 and after the preset number of the data frames are sent at each time, connection confirmation between the host and the slave machine is carried out by the host; and when the host performs directed transmission on one slave machine, high-reliability automatic reconnection between the host and the slave machine is realized through the instruction frame under the condition that a signal is recovered after being lost.