The invention discloses a circuit structure for inhibiting on-off POP sound of an audio power amplifier. The circuit structure comprises an amplifier, a bias circuit, a delay control circuit, a resistor Rin, a resistor Rf and a switch K1, wherein a basic power amplification unit is formed by the amplifier, the resistor Rin and the resistor Rf; the bias circuit supplies voltage reference and current reference to the amplifier; when an audio system is turned on or off, the delay control unit turns on or off the amplifier, the bias circuit and the switch according to different time sequences and time delays, so as to achieve the aim of inhibiting the POP sound produced when the system is turned on or off. By adopting the circuit structure, the POP sound produced when the audio system is turned on or off can be obviously inhibited, the impact to a horn is reduced and the auditory feeling of listeners can be improved.