Composition containing lycopane and thioglycoside

A technology of glucosinolate and lycopene is applied in the field of compositions containing lycopene and glucosinolate, which can solve the problems of high toxicity and insignificant effect of anticancer products, achieves good market prospects, is easy for industrial production, Quality controllable effects

Inactive Publication Date: 2007-12-19
张宏宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the shortcomings of high toxicity and ineffective effect of anti-cancer products on the market, and to provide a composition containing lycopene and glucose isothiocyanate using anti-cancer active ingredients in food

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Prepare lycopene / glucose isothiocyanate tablets according to the drug combination ratio proposed by the present invention, each tablet contains 10 mg of lycopene active ingredient and 50 mg of glucose isothiocyanate active ingredient, and a total of 1000 tablets are prepared.

[0023] Lycopene 10g

[0024] Glucose isothiocyanate 50g

[0025] Excipients Appropriate amount

[0026] Preparation method: Now accurately weigh lycopene, glucose isothiocyanate, vitamin E, lactose, microcrystalline cellulose, polyvinylpyrrolidone, and cross-linked polyvinylpyrrolidone according to the above formula ratio, mix well, dry Tablet crushing by French method, pass through 18-24 mesh sieve to granulate, add magnesium stearate and micropowder silica gel, mix evenly, and press into tablet to obtain the required lycopene / glucose isothiocyanate tablet.

Embodiment 2

[0027] Example 2 Lycopene / glucose isothiocyanate soft capsules were prepared according to the drug combination ratio proposed by the present invention, each containing 10 mg of lycopene and 50 mg of glucosinolate as active ingredients, and a total of 1000 capsules were prepared.

[0028] Lycopene 10g

[0029] Glucose isothiocyanate 50g

[0030] Excipients Appropriate amount

[0031] Preparation method: take tomato, add petroleum ether for warm soaking and extraction, evaporate petroleum ether under reduced pressure, take residue to measure lycopene content; take broccoli or other plants containing glucose isothiocyanate, add 75% ethanol for reflux extraction, Ethanol was evaporated under reduced pressure, and the residue was taken to determine the content of glucose isothiocyanate. According to the measurement results, two kinds of extracts, vitamin E, soybean oil, and beeswax were taken to make a suspension, and gelatin was added to make soft capsules to obtain lycopene / glu...

Embodiment 3

[0032] Example 3 Lycopene / glucose isothiocyanate granules were prepared according to the drug combination ratio proposed in the present invention. Each bag contained 10 mg of lycopene active ingredient and 50 mg of glucose isothiocyanate active ingredient, and a total of 1000 bags were prepared.

[0033] Lycopene 10g

[0034] Glucose isothiocyanate 50g

[0035] Excipients Appropriate amount

[0036] Preparation method: take tomato, add petroleum ether for warm extraction, evaporate petroleum ether under reduced pressure, take residue to measure lycopene content; according to the measurement result, mix with glucose isothiocyanate and mannitol, add 10% pvpK30 ethanol Soft materials made from solution, granulated with 18-24 mesh sieve, dried at 30-40°C, granulated with 14-mesh sieve and 60-mesh sieve, packed separately to obtain lycopene / glucose isothiocyanate soft granules.

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PUM

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Abstract

The present invention relates to composite containing lycopene and thioglycoside. The composite may be prepared into different food and medicine preparation, including food, oral preparation, injection, etc. through different production processes. It is superior to marketable anticancer preparation, which possesses high toxicity and low treating effect, and has controllable product quality and easy industrial production.

Description

technical field [0001] The invention relates to a composition containing lycopene and glucosinolate, which can be used as food, health product and medicine. Background technique [0002] Malignant tumor is one of the three major killers of people. Factors that cause tumors are collectively referred to as tumorigenic factors, and carcinogenic factors are factors that cause malignant tumors. Tumor-causing factors are nothing more than two factors in vivo and in vitro. In vitro factors are mainly some environmental factors, such as long-term ionizing radiation, long-term exposure to sunlight and ultraviolet rays, some chemical carcinogens (such as peroxides, coal tar, aflatoxin, etc.) and some biological factors (such as Epstein-Barr virus, etc.) . Various carcinogens are the triggers that initiate abnormal gene mutations. Oxidation is an important factor in inducing cancer. Oxygen free radicals produced in tissues can react with important macromolecules such as proteins, c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/01A61K31/70A61K31/335A61K9/20A61K9/48A61K9/14A61K9/08A61K47/30A61P35/00A61P39/06
Inventor 张宏宇
Owner 张宏宇
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