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Application of nanometer zinc oxide in preparing medicine for treating malignant tumor

A technology of nano-zinc oxide and malignant tumors, which is applied in the new application field of nano-zinc oxide, and can solve problems such as large side effects, human gene mutation, and cancer

Inactive Publication Date: 2008-02-20
王小丁 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This may be related to the large nucleus and deep staining of tumor cells, but laser treatment has its own insurmountable weakness, that is, normal cells will also die under the irradiation of laser rays, and the side effects are quite serious
[0013] In the world, there have been many serious side effects in gene therapy for cancer. Researchers believe that, in theory, this therapy may cause other cell lesions, because retroviruses randomly integrate their genomic DNA To the chromosomal DNA of the host cell, so that it may be inserted near an oncogene to cause cancer
Retroviral vectors are integrated into the host cell genome, which may cause human gene mutations and produce carcinogenicity

Method used

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  • Application of nanometer zinc oxide in preparing medicine for treating malignant tumor
  • Application of nanometer zinc oxide in preparing medicine for treating malignant tumor

Examples

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preparation example Construction

[0056] The preparation method of the above-mentioned nano-zinc oxide preparation is: mix the nano-zinc oxide, Nuodi dry powder, poloxamer, and 5-fluorouracil in the stated ratio, add an appropriate amount of distilled water and prepare it by ultrasonic waves, and prepare it at 2000r / min Centrifuge at a low speed, then add sterilized saline and a small amount of Houttuynia cordata solution, and then centrifuge at a high speed of 14000r / min to obtain part of the white precipitate, which is then added to distilled water for centrifugation, and finally filtered to prepare a nano-zinc oxide preparation. The preparation methods are all existing conventional mature technologies.

[0057] Now in conjunction with experimental example the present invention will be further described

[0058] In the following three experimental examples, experiments were carried out according to methods such as the following cell culture method, preparation of nano-zinc oxide preparation stock solution, M...

Embodiment 1

[0065] Example 1 Results Inhibition of lung cancer cell proliferation and growth in vitro

[0066] The growth inhibition of human lung cancer cell A549 by nano-zinc oxide preparations with different contents is shown in Figure 1. Compared with the control group, 10 nanograms, 50 nanograms, and 100 nanograms of drugs all have inhibitory effects on the growth of lung cancer cells, and the inhibitory effects are enhanced with the increase of the concentration.

Embodiment 2

[0067] Example 2 results in vitro inhibition of human malignant glioma cell proliferation and growth

[0068] The growth inhibition of human glioma cell U87 by different contents of nano zinc oxide preparations is shown in Fig. 2 . Compared with the control group, 10 nanograms, 50 nanograms, and 100 nanograms of the drug all had an inhibitory effect on the growth of glioma cells, and the inhibitory effect was enhanced as the concentration increased.

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Abstract

The present invention relates to a usage of nano-zinc oxide in the preparation of the drugs for treating malignant tumors, which is the usage of the nano-zinc oxide in the preparation of the anti-cancer drugs or / and the drugs for enhancing the chemotherapy sensitivity. The size of the nano-zinc oxide is less than 180 nano meters, the preferential range is 10 nano meters to 60 nano meters, and the best value is 20 nano meters. The medical hydrophilic excipients which are used conventionally are blended with the nano-zinc oxide by ultrasonic homogeneization, so as to be prepared into the capsules, tablets, powders, granules or injections and other formulations. The present invention has the effects of inhibiting proliferation and growth of the malignant tumor cells and inducing differentiation and apoptosis of the cancer cells, which can damage the protein synthesis in the tumor cells and decompose the organic matters constituting the microbes of the tumor cells by the photosensitive self-chain reaction in the tumor cells under the premise of protecting the transduction genes from being damaged by various supplements and various enzymes in the plasma or tissue cells of the body, so as to significantly improve the effect of killing microbes of the tumor cells and have great practical values in the clinical oncology.

Description

(1) Technical field [0001] The invention relates to an application of a product, in particular to a new application of nanometer zinc oxide. (two), background technology [0002] Nano-zinc oxide is a well-known new nano-material, which is widely used in many fields such as rubber and tire industry, chemical industry, coating industry, glass industry, electronics industry, food industry and medicine and health: [0003] In the rubber and tire industry, nano-zinc oxide is an essential additive, and is also used as a vulcanization activator, reinforcing agent and colorant for natural rubber, synthetic rubber and latex. The use of nanometer zinc oxide in rubber can give full play to the role of vulcanization acceleration and improve the performance of rubber, and its dosage is only 30% to 50% of ordinary zinc oxide. [0004] In the chemical industry, zinc oxide is widely used as a catalyst and desulfurizer, such as a catalyst in the synthesis of methanol and a desulfurizer in t...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K9/14A61K9/16A61K9/20A61K9/48A61K47/34A61P35/00A61K31/513A61K47/10
Inventor 王小丁李红
Owner 王小丁
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