Method for preparing nano hydroxyapatite/polymer composite bone substitution material

A technology of nano-hydroxyapatite and composite materials, applied in medical science, prosthesis, etc., to achieve high tensile and bending strength, high dispersion, and good biocompatibility

Inactive Publication Date: 2011-01-26
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method and the prepared material have not been reported at home and abroad.

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  • Method for preparing nano hydroxyapatite/polymer composite bone substitution material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) 5g polyamide (PA66) is dissolved in 20ml organic solvent formic acid;

[0036] (2) Take n-HA sol according to the design ratio (weight ratio 1:1), stir and blend with PA66 solution at 90°C for 3 hours, and make n-HA particles evenly distributed in PA66 under the action of stirring force field and composite;

[0037] (3) Centrifuge the prepared blend solution at a speed of not less than 10000r / min for more than 10min, and separate the sediment from the supernatant.

[0038](4) After the sediment was washed 6 times with deionized water, it was washed 2-3 times with ethanol. Dry the product at 65°C for 24 hours;

[0039] (5) Press and dry the composite powder at a temperature of 260° C. with a conventional thermocompression molding machine to obtain n-HA / PA66 composite material.

[0040] The experimental results show that the components of the n-HA and PA66 phases do not change after the above method is blended (X-ray diffraction results); the prepared n-HA / PA66 com...

Embodiment 2

[0042] (1) Dissolve 5g of polyurethane (PU) in 20ml of organic solvent acetic acid;

[0043] (2) Take n-HA sol according to the design ratio (weight ratio 1:1), stir and blend with PU solution at 90°C for 3 hours, and make liquid crystal n-HA particles uniform in PU under the action of stirring force field distribute and combine;

[0044] (3) Centrifuge the prepared blend solution at a speed of not less than 10000r / min for more than 10min, and separate the sediment from the supernatant.

[0045] (4) After the sediment was washed 6 times with deionized water, it was washed 2-3 times with ethanol. Dry the product at 65°C for 24 hours;

[0046] (5) The n-HA / PU composite material is obtained by hot pressing at 280° C. using a hot pressing machine.

[0047] The n-HA / PU biological composite material prepared above, its hydroxyapatite is the diameter 10-15nm long 100-200nm rod-shaped particle, content is 20-60wt%, is evenly distributed in PU matrix, makes the polymer mechanical pr...

Embodiment 3

[0049] (1) According to the chemical reaction equation: 10Ca(NO 3 ) 2 +6(NH 4 ) 3 PO 4 +2NH 3 ·H 2 O→Ca 10 (PO 4 ) 6 (OH) 2 +20NH 4 NO 3 , in order to prepare 2g nano-hydroxyapatite (n-HA), weigh (NH) according to the ratio of 1:2 4 PO 3 and Ca(NO) 3 , were dissolved in distilled water, the concentrations of the aqueous solutions were 0.05g / ml and 0.025g / ml. Gelatin was also dissolved in distilled water to make a 0.2 g / ml solution.

[0050] (2) Add 200ml glycerin, gelatin solution and Ca(NO) successively in the three-necked flask 2 solution, wherein the volume ratio of the three solutions is 1:1:2, blending and heating to 85°C, and adding (NH) dropwise to the above mixed solution at a speed of 40ml / h 4 PO 3 The solution is about 50ml, and at the same time, use commercially available ammonia (NH 3 ·H 2 O) adjust the pH value of the blend to 10. After all the dropwise addition was completed, the solution continued to react for 20 min.

[0051] (3) Then raise...

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Abstract

The invention relates to a preparation method of a nano-hydroxyapatite/polymer compound bone replacement material, wherein, the content of n-HA of the n-HA/polymer compound bone replacement material which is prepared by in situ blending of the nano-hydroxyapatite (n-HA) non-hydrolytic sol and polymer is 20 to 60wt percent. The preparation method includes: the polar and hydrophilic polymer is dissolved in organic solvent; the mixture is stirred and blended with the n-HA sol to lead the n-HA granules are evenly distributed in the polymer to form chemical bond with the polymer; and then the n-HA/polymer compound material is obtained by centrifugal separation, drying, hot-press molding and so on. The hydroxyapatite with nano-scale in the compound bone replacement material prepared by the invention is evenly distributed in the polymer substrate and forms strong chemical bond with the polymer. The invention not only has high tensile and bending strength, appropriate elastic modulus and other mechanical performances, but can also ensure that the material has good biocompatibility, thus meeting the clinical using requirement of human bearing bone repair material.

Description

【Technical field】 [0001] The invention belongs to the preparation technology of inorganic / organic biological composite materials, in particular to a preparation method of nano-hydroxyapatite / polymer composite bone substitute material obtained by utilizing the high dispersion and stability of particles in hydroxyapatite sol. 【Background technique】 [0002] Human bone is a natural nano-hydroxyapatite (n-HA) / collagen fiber composite material with complex hierarchical structure and excellent mechanical properties. In recent years, with the goal of biomimetic biological structure and function, research on nano-hydroxyapatite and polymer composite bone repair materials has become a hot spot. [0003] Looking at the research at home and abroad, the developed composite materials have their own characteristics, but there are also certain problems. For example: the high molecular weight polyethylene / HA composite material developed in the early stage, because there is no chemical bond...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46
Inventor 陈民芳沈荣臻谭军军刘德宝
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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