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Preparation of Enrofloxacin microcapsule and method of preparing the same

A technology of enrofloxacin and preparations, which is applied in the field of enrofloxacin microcapsule preparations and its preparation, can solve the problems of poor production environment for workers, complicated process, incomplete packaging, etc., achieve no toxic side effects, high total yield, The effect of expanding the range of use

Active Publication Date: 2008-10-01
GUANGDONG HINAPHARM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production process of this method is relatively dusty. In addition to the poor production environment of the workers, through the analysis of the products on the market, it is found that most of them have the disadvantages of incomplete packaging and low coating rate.
The Chinese patent application with the application number 200610049243.X discloses a preparation method of taste-masking enrofloxacin, that is, mixing gelatin and glycerin to make a gelatin-plasticizer composite solution, and then adding enrofloxacin to make suspension, and then the suspension is spray-dried, which is very complicated and inconvenient to operate

Method used

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  • Preparation of Enrofloxacin microcapsule and method of preparing the same
  • Preparation of Enrofloxacin microcapsule and method of preparing the same
  • Preparation of Enrofloxacin microcapsule and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Select auxiliary material 1 stearic acid (conform to " Chinese Pharmacopoeia " or " United States Pharmacopoeia ", " European Pharmacopoeia ", the quality standard of stearic acid (Stearic Acid) in " British Pharmacopoeia ") 225kg drop into chemical tank 3, as figure 1 As shown, heat to 80°C, stir continuously, until the auxiliary material 1 is completely melted; pump the melted stearic acid from the chemical material tank into the batching tank 4, and at the same time put 25kg of enrofloxacin raw material 2 that has been accurately weighed into the batching tank 4. High-speed emulsification, shearing and stirring for 10 minutes, during which the temperature should be controlled at 80°C; import the prepared material into the storage tank 5, and heat the temperature to 80°C-100°C; start the feeding spray device 6, the spray device 6 can be a high-speed centrifugal spray dryer, which granulates the materials prepared in the storage tank 5 through spray cooling (cooling sys...

Embodiment 2

[0034] Select 120kg of auxiliary material glyceryl monostearate and put it into the chemical material tank, heat to 70°C, and stir continuously until the auxiliary material is completely melted; pump the melted calcium stearate monoglyceride from the chemical material tank Weigh 80kg of enrofloxacin into the batching tank, shear and stir for 8 minutes, during which the temperature should be kept at 80°C; import the prepared materials into the storage tank, and heat the temperature to 80°C-100°C; start feeding Spray device, granulate the materials in the storage tank through spray freezing equipment; sieve and collect the finished product particles with a 200μm-850μm vibrating sieve. Finally, 190 kg of finished enrofloxacin microcapsule preparation (40%) was obtained, the particle size was 200 μm-850 μm, and the yield could reach 95%.

Embodiment 3

[0036] Select 60kg of glyceryl monostearate, 60kg of fat powder, and 20kg of paraffin wax into the chemical material tank, heat to 90°C, and stir continuously until all the auxiliary materials are melted; pump the melted auxiliary materials from the chemical material tank into the batching tank, and at the same time put the Put 60kg of accurately weighed enrofloxacin into the batching tank, shear and stir for 8 minutes, during which the temperature should be kept at 80°C; import the prepared materials into the storage tank, and heat the temperature to 80°C-100°C; start the conveying The material spray device is used to granulate the materials prepared in the storage tank through spray freezing; the finished product particles are collected by sieving with a 200μm-850μm vibrating sieve. Finally, 190kg of finished enrofloxacin microcapsule preparations (30%) were obtained, the particle diameter was 200 μm-850 μm, and the yield could reach 95%.

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Abstract

The invention discloses an enrofloxacin microcapsule preparation and a preparation method thereof. The enrofloxacin microcapsule preparation is prepared by 5 percent to 90 percent of enrofloxacin raw material and 95 to 10 percent of accessories, and the accessory is one of the followings or a mixture mixed by a plurality of the followings: 12 to 18 carbon fatty acid, calcium stearate monoglycerol ester, stearyl alcohol, saturated triglyceride, glycerol monoester, paraffin, animal wax, vegetable wax and fat powder, etc.. The appearance of the enrofloxacin microcapsule preparation is a white or light yellow spherical granule, the dispersion performance is good, the used accessory is safe, and the enrofloxacin microcapsule preparation has no toxicity or side effects for livestock and poultry and has a gradual release in stomach and intestine, thus maintaining the durability of the efficacy.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an enrofloxacin microcapsule preparation and a preparation method thereof. Background technique [0002] Enrofloxacin is a synthetic animal-specific antibacterial drug, which belongs to the third-generation quinolone preparations. Enrofloxacin has a broad-spectrum bactericidal effect and is effective for bacteria in the stationary phase and growth phase. It has a good killing effect on a variety of Gram-positive bacteria and Gram-negative bacteria, as well as mycoplasma, such as Pseudomonas aeruginosa , Escherichia coli, Salmonella, Shigella, Klebsiella, Pasteurella, Proteus, Staphylococcus, Chlamydia, etc. [0003] Because enrofloxacin acts on the DNA helicase of bacterial cells, it can prevent bacteria from forming supercoils and damage chromosomes, thereby producing a bactericidal effect. Because its bactericidal mechanism is different from other drugs, the chance of cros...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/496A61P31/04
CPCA61K31/496A61K9/5015A61K9/5063A61P31/04A61K9/50
Inventor 周玉岩
Owner GUANGDONG HINAPHARM PHARMA CO LTD
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