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Large particle diameter mono-disperse polymer microspheres containing epoxy group and preparation method thereof

A technology of polymer microspheres and epoxy groups, applied in the field of polymer microspheres and their preparation, can solve the problems that separation accuracy and purification efficiency cannot be guaranteed, separation and low reactivity, etc. Broad application prospects, great agglutination effect

Inactive Publication Date: 2011-05-25
SHANGHAI HUAMING HI TECH GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the polymer microspheres prepared by the existing technology, such as the technology reported in CN200510075057.9A and CN1876688A literature, have low reactivity, and cannot accurately separate and purify specific protein molecules according to different protein molecules, so that the separation cannot be guaranteed Accuracy and purification efficiency

Method used

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  • Large particle diameter mono-disperse polymer microspheres containing epoxy group and preparation method thereof
  • Large particle diameter mono-disperse polymer microspheres containing epoxy group and preparation method thereof
  • Large particle diameter mono-disperse polymer microspheres containing epoxy group and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Prepare PS seed microspheres as follows:

[0047] Take by weighing 60 g of aqueous ethanol solution with a volume concentration of 95%, 1.2 g of PVP (polyvinylpyrrolidone), 0.3 g of AIBN (azobisisobutyronitrile), and 30 g of styrene, mix them uniformly and place them in a machine equipped with mechanical stirring and reflux condensation. tube and a nitrogen-protected three-neck flask were polymerized in a water bath at 70°C for 8 hours, and cooled and left to stand after the reaction was completed. Centrifuge the emulsion obtained by the reaction at a speed of 4000r / min, pour off the supernatant, add absolute ethanol to ultrasonically disperse, and then centrifuge; repeat this process for 3 times to remove unreacted monomers and dispersion stabilizers . Dry under vacuum at 60°C for 8 hours to obtain PS seed microspheres as a white powder product. The particle size of the styrene seed microspheres is 2.1 μm, and the distribution index is 3.2%.

[0048] Pre-swell:

[00...

Embodiment 2

[0056] Preparation of PMMA seed microspheres:

[0057] With 1.5g dispersant PVP (polyvinylpyrrolidone), 10g monomer MMA (methyl methacrylate), 0.1g initiator AIBN (azobisisobutyronitrile), be dissolved in the mixed solvent that ethanol and water form (ethanol : water=11:9), drop into the there-necked flask that stirrer is housed, reflux condenser and nitrogen protection device, react 6h at 70 ℃, cool after reaction finishes, leave standstill, then carry out centrifugal sedimentation with 3000r / min rotating speed , pour off the supernatant, add absolute ethanol to wash, and then centrifuge; repeat this way for 3 times to remove unreacted monomers, oligomers and dispersion stabilizers, and finally dry at 60°C for 24h under vacuum to obtain White powder product PMMA seed microspheres, ready for use.

[0058] Get above-mentioned PMMA microsphere 0.7g and DBP (glycidyl methacrylate) 0.1g and join in 25g containing SDS (sodium dodecyl sulfate) 0.3% (wt) aqueous solution respectivel...

Embodiment 3

[0061] Get PS seed microsphere 0.7g prepared in Example 1 and DBP (glycidyl methacrylate) 0.07g and join in 30g containing SDS (sodium dodecyl sulfate) 0.2% (wt) aqueous solution respectively, ultrasonic emulsification 55min respectively , the emulsions were mixed together, stirred in a three-neck flask equipped with mechanical stirring, reflux condenser, and nitrogen protection, and swelled at 35° C. for 12 hours to obtain primary expanded polystyrene microspheres (4.8 μm). Take GMA (glycidyl methacrylate) 0.7g, BPO (dibenzoyl peroxide) 0.035g, mix and dissolve, add to 140g SDS (sodium dodecyl sulfate) 0.2% (wt) aqueous solution and ultrasonically emulsify for 20min , then slowly added dropwise into the system, continued swelling for 6 hours, then added 0.7g of polyvinylpyrrolidone, raised the temperature to 60°C, polymerized for 8 hours, and synthesized a monodisperse polystyrene resin with a particle size of 7 μm and containing epoxy groups. The rate is 93%.

[0062] The p...

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Abstract

The invention provides a large particle diameter mono-dispersed polymeric micro-sphere containing epoxy groups as well as the preparation method thereof, wherein the surface of the micro-sphere contains the epoxy groups, the diameter of the micro-sphere is 5-10 micrometers, and the particle distribution factor is smaller than 10 percent. The invention comprises the method that polystyrene or polymethyl methacrylate is taken as the seed, and glycidyl methacrylate is taken as the second monomer, so as to carry out the activated swollen-state polymerization, the micro-sphere is made of the material with large specific surface area, strong absorbability, great agglutination and strong surface reaction ability, and the existing of the functional groups (epoxy groups) on the micro-sphere enables the micro-sphere to be widely applied to biological and medical fields of standard measurement, immunological techniques, clinical examination and diagnosis, cytological study, blood circulation andso on, in particular to the high-technology fields, and the application prospect is wide.

Description

technical field [0001] The invention relates to a polymer microsphere and a preparation method thereof. Background technique [0002] Monodisperse polymer microspheres have the characteristics of large specific surface area, strong adsorption, strong agglutination and strong surface reaction ability, which make them widely used in standard measurement, immune technology, clinical testing and diagnosis, cytology research and blood circulation, etc. It has been widely used in the fields of biology and medicine. Its main functions are as follows. 1) Micro-memory: Store and protect certain substances so that they can be released at the required speed at the required time and place (multidimensional controlled release). The most typical application is drug delivery system. 2) Microreactor: The reaction is limited in a special micro space to generate special substances. A typical application is to use the cavity in the microsphere or the space between the microspheres as a tem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/285B01J13/14C07K1/22C07K17/00A23J1/06
Inventor 杨景辉张晓宁陈刚马新胜吴秋芳孔凡滔
Owner SHANGHAI HUAMING HI TECH GRP
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