Mesoporous calcium silica xerogel for treating skin ulcer and preparation and use thereof

A mesoporous calcium-silicon, skin ulcer technology, applied in skin diseases, pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, etc. problems, to achieve the effects of pain relief, excellent moisturizing, and sufficient safety

Inactive Publication Date: 2009-01-21
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The technical problem to be solved by the present invention is to provide a new method for overcoming the defects of the existing mesoporous calcium-silica xerogels with uneven pore size distribution,

Method used

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  • Mesoporous calcium silica xerogel for treating skin ulcer and preparation and use thereof
  • Mesoporous calcium silica xerogel for treating skin ulcer and preparation and use thereof
  • Mesoporous calcium silica xerogel for treating skin ulcer and preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0057] Example 1

[0058] 2g P123 (polyoxyethylene ether-polyoxypropylene ether-polyoxyethylene ether triblock copolymer) was added to the ethanol aqueous solution, stirred at 40°C for 4h, added 4.25g TEOS to the above solution, and then added 80ml 2mol / L of hydrochloric acid solution, after stirring for 1h, slowly add Ca(NO 3 ) 2 Solution (Ca(NO 3 ) 2 2.0g), after stirring for 24h, the solution was transferred to a polytetrafluoroethylene-lined reactor and placed in an oven, crystallized at 110°C for 1 day, the obtained solution was washed with deionized water, filtered, and dried at room temperature. ; In a temperature-programmed tube furnace, the temperature was raised to 500°C at 1°C / min in an air atmosphere, and the temperature was kept constant for 6h to remove the surfactant. After calcination, it is cooled naturally, and the powder is passed through a 150-mesh standard sieve and sealed for use. The powder is a calcium-calcium-silica xerogel (see figure 1 ). The...

Example Embodiment

[0059] Example 2

[0060] At room temperature, 1 g of P123 was added to 1 g of absolute ethanol (analytical grade), slowly added dropwise, and after uniform stirring, 2.08 g of ethyl orthosilicate (TEOS, analytically pure), 1.71 g of Ca (NO 3 ) 2 and 0.2 g of hydrochloric acid (1 mol / L), and after stirring uniformly for 2 hours, the sol was injected into a polyethylene mold for sealing and aging for 2 days, and then dried at 100° C. for 12-24 hours. The sample was put into corundum crucible, heated to 600 ℃ with a program-controlled electric furnace, and after natural cooling, it was ground through a 100-mesh standard sieve, and sealed for use. The powder is calcium-containing calcium-silica xerogel, denoted as L-2, the pore size is 3nm, and the specific surface is 650m 2 / g, the porosity is 90%, and the molar amount of silicon oxide accounts for the percentage of the total molar amount of silicon oxide and calcium oxide: 80%.

Example Embodiment

[0061] Example 3

[0062] According to TEOS:CaCl 2 :CTAB:NH 3 .H 2 O:H 2 O=1:0.10:0.6:0.47:65 molar ratio, weigh 1 g of cetyltrimethylamine bromide (CTAB), dissolve it in ethanol aqueous solution, then add ammonia water, and maintain the system at a constant temperature at 35°C Stir for 1 hour to dissolve, slowly add ethyl orthosilicate, then add CaCl 2 . Continue stirring for 4-5 hours. It was transferred into a polytetrafluoroethylene mold to obtain a sol; the sol was aged at 37° C. for 48 hours, and dried at 100° C. for 18 hours to obtain a gel. The sample was placed in a muffle furnace, heated at a rate of 5°C / min, and calcined at 550°C for 6 hours to remove the template agent. After calcination, calcium-containing calcium-silicon xerogel material is obtained, with a pore size of 2nm and a specific surface of 600m. 2 / g, the porosity is 80%, and the molar amount of silicon oxide accounts for the percentage of the total molar amount of silicon oxide and calcium oxid...

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Abstract

The invention discloses a mesoporous lime-silicate xerogel, which contains silicon oxide, or silicon oxide and calcium oxide. In the power X-ray diffraction (XRD) pattern, 1 to 3 peaks are between 0 to 2 degrees on the abscissa 2 theta and holes of the mesoporous lime-silicate xerogel are orderly arranged. The invention also discloses the preparation method and the application in preparing drugs or materials for curing skin ulcer. The mesoporous lime-silicate xerogel of the invention, with even aperture size, high porousness, even arrangement of holes and good hole appearance, can effectively promote the healing of ulcer in a simple use method and can cure skin ulcer by compounding with drugs or growth factors. Te mesoporous lime-silicate xerogel can be used for curing skin ulcer on different medical occasions, such as cervical erosion, diabetic ulcer, wound surface due to operation and trauma, bedsore, stress ulcer, skin and mucosal ulcer, erosive lesion, local II or III burn and scald wound, wound difficult to heal, etc.

Description

technical field [0001] The invention relates to a xerogel and its preparation method and application, in particular to a mesoporous calcium silica xerogel and its preparation method and application. Background technique [0002] Skin ulcer refers to a class of diseases caused by different causes of body surface tissue necrosis, ulceration, and defect. Skin ulcer is a disease characterized by ulcerative lesions of the skin and mucous membranes. During the course of the disease, there are pathological changes such as wound exudation, infection, and erosion, as well as skin and mucous membrane ulceration and soft tissue damage, and ultimately rely on connective tissue and epithelial tissue to repair the wound. However, after human skin and mucous membranes are injured, not only the morphology and function of the cells in the injured area undergo pathophysiological changes, but also the injured cells and dead cells release a large number of active substances, such as histamine,...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K9/00A61P17/02
Inventor 刘昌胜魏杰戴程隆袁媛
Owner EAST CHINA UNIV OF SCI & TECH
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