Method for preparing magnetic temperature-sensitive composite microsphere with nuclear shell structure by adopting in-situ grafting technique

A core-shell structure and composite microsphere technology, applied in the fields of polymer materials and biomedical engineering, can solve the problems of poor particle core-shell binding force, low magnetic content, and difficult control of the molecular weight of the shell polymer, and achieve a synthesis method. Simple, easy-to-use effects

Inactive Publication Date: 2009-10-21
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above-mentioned several preparation methods usually adopt the conventional free radical polymerization method, the molecular weight of the shell layer polymer is not easy to control, and the molecular chain and the core layer inorganic particles are

Method used

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  • Method for preparing magnetic temperature-sensitive composite microsphere with nuclear shell structure by adopting in-situ grafting technique
  • Method for preparing magnetic temperature-sensitive composite microsphere with nuclear shell structure by adopting in-situ grafting technique

Examples

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Example Embodiment

[0020] Example 1

[0021] In 100ml of 5% silane coupling agent KH-570 ethanol solution, add 0.5g of ferroferric oxide nano-magnetic particles for ultrasonic dispersion, raise the temperature to 60℃ and react for 6 hours. After magnetic separation, the product is cleaned with ethanol five times. Dry in a vacuum oven. Disperse the prepared dry magnetic particles in 50ml N,N-dimethylformamide, weigh 1.13g monomer N-isopropylacrylamide (NIPAAm), 1.00g N,N-dimethylacrylamide, 0.33 g azobisisobutyronitrile, 0.96 g isocyanopropyl dithiobenzoate, carry out solution polymerization, polymerization temperature is 80℃, polymerization time is 3 hours, after magnetic separation and vacuum drying of the obtained product , The magnetic temperature-sensitive composite microspheres are obtained, and the particle size of the composite microspheres is monodisperse and in the range of 30nm-500nm. figure 1 Is the molecular structure of the magnetic composite microspheres, from figure 2 It can be seen ...

Example Embodiment

[0022] Example 2

[0023] In 500ml of 6% silane coupling agent KH-570 ethanol solution, add 10g of ferroferric oxide nano-magnetic particles for ultrasonic dispersion, raise the temperature to 50℃ and react for 16 hours. After magnetic separation, the product is washed five times with acetone and put in Dry in a vacuum oven. Disperse the prepared dry magnetic particles in 250ml 1,4-dioxane, weigh 22.6g monomer N-isopropylacrylamide (NIPAAm), 40.0g N,N-diethylacrylamide, 0.6568 g benzoyl peroxide, 3.24 g cumyl dithiobenzoate, carry out solution polymerization, polymerization temperature is 75℃, polymerization time is 6 hours, after magnetic separation and vacuum drying of the obtained product, magnetic Temperature-sensitive composite microspheres. The particle size of the composite microspheres is monodisperse and is in the range of 30nm-500nm. Fig. 1 is the molecular structure of magnetic composite microspheres, from figure 2 It can be seen that this composite microsphere has bett...

Example Embodiment

[0024] Example 3

[0025] In 1000ml of 4% silane coupling agent KH-570 ethanol solution, add 15g of ferroferric oxide nano magnetic particles for ultrasonic dispersion, raise the temperature to 70℃ and react for 10 hours. After magnetic separation, the product is washed five times with tetrahydrofuran and put in Dry in a vacuum oven. Disperse the prepared dry magnetic particles in 150ml N,N-diethylformamide, weigh 11.3g monomer N-isopropylacrylamide (NIPAAm), 10.0gN,N-dimethylacrylamide, 10.0 gN,N-diethylacrylamide, 0.3284g dilauroyl peroxide, 1.21g α-dithionaphthoic acid isobutyronitrile, carry out solution polymerization, polymerization temperature is 70℃, polymerization time is 8 hours, it will be prepared After magnetic separation and vacuum drying of the product, the magnetic temperature-sensitive composite microspheres are obtained. The particle size of the composite microspheres is monodisperse and is in the range of 30nm-500nm. figure 1 Is the molecular structure of the m...

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Abstract

The invention belongs to the technical field of medical engineering of polymer material and dust, in particular to a method for preparing magnetic temperature-sensitive composite microsphere with nuclear shell structure by adopting in-situ grafting technique. The preparation method comprises the following steps: carrying out surface modification to ferroferric oxide nano magnetic particles, leading the surface thereof to be carried with polymerisable double bonds, utilizing reversible addition-fragmentation chain transfer (RAFT) polymerization technique, carrying out in-situ grafting polymerization to N-isopropylacrylamide and hydrophilic allyl monomer on the surface of the magnetic particles to form a temperature-sensitive polymer, and obtaining the nuclear shell structure composite material with temperature-sensitive hydrophilic shell and controllable magnetothermal effect magnetic nuclear. The nuclear shell structure composite material has magnetothermal effect of ferroferric oxide, magnetic positioning capability and temperature responsiveness of the temperature-sensitive polymer simultaneously, and has wide application in fields of control release, immunoassay, memory element switches and sensors and the like. The synthesis method is simple and easy to operate, and the materials can be produced industrially, thus having good promotion and application values.

Description

technical field [0001] The invention belongs to the technical field of macromolecular materials and biomedical engineering, and specifically relates to a method for preparing magnetic temperature-sensitive composite microspheres with a core-shell structure by an in-situ grafting process. Background technique [0002] Polymer-modified magnetic particles are widely used in biochemical fields such as immobilized enzymes, cell optimization, protein separation, and targeted drugs because they have both the surface functionality of polymers and the magnetic responsiveness of magnetic cores. The relatively mature preparation method of magnetic polymer particles is monomer polymerization method, including suspension polymerization method, emulsion polymerization method, dispersion polymerization method and so on. However, the above-mentioned several preparation methods usually adopt the conventional free radical polymerization method, the molecular weight of the shell layer polymer ...

Claims

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Application Information

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IPC IPC(8): B01J13/02H01F1/11C12N11/08C07K1/14
CPCC08F4/32
Inventor 任杰曹阳李建波陈大凯
Owner TONGJI UNIV
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