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Preparation method and application of strontium-incorporated hydroxyapatite

A technology of strontium hydroxyapatite and strontium oxide, which can be applied in the fields of phosphorus compound active ingredients, medical science, prosthesis, etc., can solve problems such as high price and achieve the effect of good biological activity

Inactive Publication Date: 2010-01-20
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The raw materials such as tricalcium phosphate and tetracalcium phosphate used in such methods are relatively expensive; some prepare strontium-containing phosphate precursors, and introduce NO 3 - Ions that are harmful to the human body need to be cleaned many times

Method used

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  • Preparation method and application of strontium-incorporated hydroxyapatite
  • Preparation method and application of strontium-incorporated hydroxyapatite
  • Preparation method and application of strontium-incorporated hydroxyapatite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: Preparation of strontium hydroxyapatite powder

[0037] Glass preparation process: the glass block is prepared by the melting method, and the carbonates, silicon dioxide, boric acid, etc. corresponding to various alkali metals and alkaline earth metals corresponding to the glass components are fully mixed according to the mass ratio; then The platinum crucible with mixed raw materials is placed in a silicon-molybdenum furnace at 1100-1150°C, melted for 2-3 hours, the melt is quenched on a steel plate to obtain block glass, and the glass block is ground into powder for later use.

[0038] Take the mole percentage to form 14Na 2 O·6MgO·22CaO·2SrO·18SiO 2 36B 2 o 3 ·2P 2 o 5 After being crushed, sieved to obtain irregularly shaped glass particles with a diameter of 150-300 microns, soaked in a physiological simulation solution (pH=7.2-7.4), in a closed container, under normal pressure (greater than 0.15 MPa), in the air containing carbon dioxide, react ...

Embodiment 2

[0039] Example 2: Preparation of strontium hydroxyapatite scaffold

[0040] The preparation method of the glass is the same as that in Example 1 except for the difference in composition.

[0041] Take the mole percentage to form 14Na 2 O 4MgO 22CaO 4SrO 18SiO 2 36B 2 o 3 ·2P 2 o 5 After crushing, sieve to obtain glass particles with a diameter of less than 50 microns, prepare glass supports by template method, soak in physiological simulation fluid (SBF) (pH = 7.2 ~ 7.4), in a closed container, higher than normal pressure Under low temperature (greater than 0.15MPa), the powder is reacted with the solution in a constant temperature water bath higher than 38°C and lower than 42°C. The reaction time is 14 days. After the reaction, the product is filtered out, washed with distilled water, and dried at 90°C to obtain the shape Same size white stand. Through XRD analysis, the crystalline phase after this scaffold reaction is hydroxyapatite (see Figure 6 ), observed by SEM,...

Embodiment 3

[0042] Embodiment 3: Preparation of strontium hydroxyapatite by hydrothermal method

[0043] The preparation method of the glass is the same as that in Example 1 except for the difference in composition.

[0044] Take the mole percentage to form 14Na 2 O·2MgO·22CaO·6SrO·18SiO 2 36B 2 o 3 ·2P 2 o 5 The glass is crushed and sieved to obtain irregularly shaped glass particles with a diameter of less than 50 microns, soaked in a dipotassium hydrogen phosphate solution with a concentration of 0.2mol / L (pH=7.2~7.4), in an autoclave, at React in a thermostat at 200°C for 2 days. After the reaction, the particles are washed with distilled water and dried at 90°C to obtain white blocks with the same dimensions. Through XRD analysis, the product of this block is strontium hydroxyapatite (see Figure 8 ), observed by SEM, the surface is a fusiform crystal composed of a complete thin plate with a long diameter of about 500-600nm, a short diameter of about 300-400nm, and a plate thi...

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Abstract

The invention belongs to the biomaterial technical field and particularly relates to a preparation method and an application of strontium-incorporated hydroxyapatite. The preparation method comprises the following steps: soaking borate glass or phosphate vitreum containing strontium and calcium with a certain shape in phosphate solution, adjusting the pH of the solution to more than 7, depositing nanoscale strontium-incorporated hydroxyapatite on the surface of glass at 20-250 DEG C under the pressure of 0.10-4.00MPa; and forming strontium-incorporated hydroxyapatite body with the same appearance and the size of glass in situ of the glass. The net formation oxide of the borate glass or phosphate glass is B2O3 or P2O5 or both or B2O3 and fewer SiO2 or P2O5 and fewer SiO2 or B2O3, P2O5 and fewer SiO2. The gap oxide of glass net contains one or more of other univalent, divalent, trivalent and tetravalent metal oxides beside CaO and SrO so as to adjust the dissolution velocity of glass. The method has simple device, easy operation and low cost. By adopting different glass compositions or different reaction conditions, strontium-incorporated hydroxyapatites with various sizes or nanoscale strontium-incorporated hydroxyapatites with various shapes can be obtained. The strontium-incorporated hydroxyapatite with a certain shape and properties can be used as the bone filler or bone tissue engineering scaffold for repairing bones or curing osteoporosis.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a preparation method and application of strontium hydroxyapatite. Background technique [0002] Hydroxyapatite is an important inorganic mineral component of human and animal bones and teeth. It has good biocompatibility and bioactivity, and can form a strong chemical bond with human or animal bone tissue. However, in addition to hydroxyapatite, the inorganic components in human bones also include carbonate and sodium, potassium, silicon, strontium, zinc and other ions; some studies have also shown that strontium can promote the proliferation of osteoblasts, and at the same time, it can promote the proliferation of osteoclasts. It has a certain inhibitory effect (the effect of strontium-doped calcium polyphosphate on osteoclasts, China Tissue Engineering Research and Clinical Rehabilitation, Volume 12, 2008, Phase 1). Obtain biomineralized nano-sized str...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/54A61L27/58A61K33/42A61P19/10
Inventor 黄文旵张欣顾刈非王德平周萘
Owner TONGJI UNIV
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