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Method for extracting succinic acid from succinic acid fermentation liquor

A technology of succinic acid and fermentation broth, applied in the separation/purification of carboxylic acid compounds, ammonium sulfate, organic chemistry, etc., can solve the problems of high operating cost, complex process, high energy consumption, and achieve low consumption of raw and auxiliary materials , The effect of simple process operation and high product yield

Active Publication Date: 2010-03-10
ANHUI BBCA FERMENTATION TECH ENG RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] U.S. Patent No. 5,168,055 discloses the method for extracting succinic acid by the calcium salt method, and its shortcoming is to produce calcium sulfate waste
U.S. Patent US5958744 uses ammonium salt to extract succinic acid, which requires pyrolysis of sulfate at high temperature, which has complicated process and high operating cost
U.S. Patent No. 5,034,105 discloses a method for extracting succinic acid by electrodialysis, which has high energy consumption and cannot handle divalent cations
Chinese patent CN1887843A discloses a method for extracting succinic acid by acidification. In this method, a large amount of inorganic salts exist in the crystallization process, which is not conducive to the crystallization process.
Chinese patent CN101348429A discloses a method for cationic resin exchange to extract succinic acid in fermentation broth. During the production process, ammonium bicarbonate is used for elution, and the obtained sodium bicarbonate needs to be removed from ammonia, and the resin regeneration is cumbersome.
Chinese patent CN101348428A discloses a method for extracting succinic acid in fermented liquid by anionic resin, which has a small amount of resin adsorption and does not have industrial value
Solvent extraction needs to consume a large amount of expensive organic solvents during the extraction process, and the toxicity of residual solvents has a negative impact on product quality
[0004] In summary, the current method for extracting succinic acid from succinic acid fermentation broth has high production costs and complex processes, which are not conducive to industrialized production

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  • Method for extracting succinic acid from succinic acid fermentation liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The succinic acid fermentation liquid is obtained through the anaerobic fermentation of the carbohydrate by microorganisms.

[0026] Add 0.9 g of flocculant polyacrylamide to 30 L of succinic acid fermentation broth, stir at 85°C for 30 minutes, and centrifuge to obtain filtrate—magnesium succinate fermentation serum. Slowly add ammonia solution with a mass volume ratio (g / 100ml) of 17% to 35L of magnesium succinate fermentation supernatant with a concentration of 5.6% (g / 100ml), the addition amount is 2.8L, keep it for 1 hour, centrifuge Separate and wash the filter cake with a little water. The obtained magnesium hydroxide can be used for succinic acid fermentation.

[0027] The ammonium succinate solution obtained after centrifugation was 35.6L, which was pumped into the 001×7 cation exchange column at a flow rate of 1.5BV / h, and the effluent was succinic acid solution. (g / 100ml) dilute sulfuric acid solution for regeneration, and the regeneration solution is ammon...

Embodiment 2

[0030] The succinic acid fermentation liquid is obtained through the anaerobic fermentation of the carbohydrate by microorganisms.

[0031] Add 0.9 g of flocculant polyacrylamide to 30 L of succinic acid fermentation broth, stir at 85° C. for 20 minutes, and centrifuge to obtain magnesium succinate fermentation supernatant. Slowly add 30% (g / 100ml) of ammonium carbonate aqueous solution to 35L of magnesium succinate fermented supernatant liquid with a concentration of 5.8% (g / 100ml). Wash the filter cake with a small amount of water. The resulting magnesium carbonate is used for succinic acid fermentation.

[0032] 37.1 L of ammonium succinate solution obtained after centrifugation was pumped into a 001×7 cation exchange column at a flow rate of 1.5 BV / h, and the effluent was succinic acid solution. After rinsing the separation column with a small amount of water, it is regenerated with 4% dilute sulfuric acid solution, and the regenerated solution is ammonium sulfate soluti...

Embodiment 3

[0035] The succinic acid fermentation liquid is obtained through the anaerobic fermentation of the carbohydrate by microorganisms.

[0036] 30 L of succinic acid fermentation broth was filtered at 70° C. using a membrane with a pore size of 0.05 μm to obtain magnesium succinate fermentation serum. Slowly add 30% ammonium bicarbonate aqueous solution into 36L concentration of magnesium succinate fermented supernatant liquid of 5.4% (g / 100ml), its addition is 7.8L, keep 1 hour, centrifuge, and wash filter with a small amount of water cake. The resulting magnesium carbonate is used for succinic acid fermentation.

[0037] 40.8L of ammonium succinate solution obtained after centrifugation was pumped into a 001×7 cation exchange column at a flow rate of 1.5BV / h, and the effluent was succinic acid solution. After rinsing the separation column with a small amount of water, it is regenerated with 4% dilute sulfuric acid solution, and the regenerated solution is ammonium sulfate solu...

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Abstract

The invention provides a method for extracting succinic acid from succinic acid fermentation liquor. The method includes that succinic acid fermentation liquor produced by anaerobic fermentation is filtered, filtrate directly reacts with ammonia water, ammonium carbonate or ammonium bicarbonate, the obtained filtrate is treated by resin, the obtained solution is subject to decolouration, concentration and centrifugal separation, thus obtaining succinic acid crystal. The method of the invention has the characteristics of low raw material consumption, simpler technology, short operational process, easy control and low cost.

Description

technical field [0001] The invention relates to a method for separating and extracting succinic acid, in particular to a method for extracting succinic acid from a succinic acid fermentation broth. Background technique [0002] Succinic acid, also known as succinic acid, is widely used in medicine, pesticide, fuel, fragrance, paint, food, plastic and photographic material industries. Succinic acid, as a tetracarbonic acid, is an excellent chemical platform product that can replace many commodities based on benzene and petrochemical intermediates, which can reduce the production and consumption of more than 250 phenyl chemicals pollution. At present, there are two main methods for the preparation of succinic acid: one is produced by petrochemical production, and the other is produced by microbial fermentation. The production cost of the petrochemical method is high, the pollution is serious, and it is restricted to a large extent; the production of succinic acid by the micr...

Claims

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Application Information

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IPC IPC(8): C07C55/10C07C51/42C07C51/47C01C1/24
Inventor 李荣杰尚海涛潘声龙
Owner ANHUI BBCA FERMENTATION TECH ENG RES
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