Compound topical combination drug for treatment of acne and preparation method thereof
A drug and compound technology, applied in the field of compound external combination drugs and their preparation, can solve the problems of single, at most 1-2, many adverse reactions, single effect, etc., to achieve good patient compliance and reduce skin dryness. , Easy to spread effect
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[0021] Example 1:
[0022] The effective active ingredients of this example are all-trans retinoic acid 0.025% (weight percentage, the same below), clindamycin phosphate 1% (calculated as clindamycin) and metronidazole 2%, and the matrix carrier is Carbomer, humectant urea and glycerin, transdermal absorbent dimethyl sulfoxide, propylene glycol, azone, etc., antioxidant, metal ion chelating agent, preservative, solubilizer, ethanol, etc.
Example Embodiment
[0023] Example 2:
[0024] The effective active ingredients in this example are tazarotene 0.03%, clindamycin hydrochloride 1% (calculated as clindamycin) and metronidazole 1.5%, the matrix carrier is carbomer, humectant urea, transdermal Absorbents such as dimethyl sulfoxide, propylene glycol, azone, etc., antioxidants, metal ion chelating agents, preservatives, solubilizers, ethanol, etc.
Example Embodiment
[0025] Example 3:
[0026] The effective active ingredients of this example are all-trans retinoic acid 0.025%, clindamycin hydrochloride 1% (calculated as clindamycin) and tinidazole 2%, the matrix carrier is carbomer, humectant glycerin and Urea, transdermal absorbent dimethyl sulfoxide, propylene glycol, azone, etc., antioxidants, metal ion chelating agents, preservatives, solubilizers, ethanol, etc.
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