Degradable medical composite conduit containing functional nano coating and preparation method thereof

A nano-coating and functional technology, applied in the direction of catheters, other medical devices, etc., can solve the problem of difficult control of the drug release rate, degradable catheter degradation rate, etc., to achieve good biodegradability, high specific surface area, good biophase capacitive effect

Inactive Publication Date: 2011-01-19
苏州同科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a degradable medical composite catheter containing a functional nano-coating, which solves the difficulty in controlling the drug rel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0038] Example 1 Preparation of three-layer degradable medical composite catheter

[0039] Take 140g polylactic acid (molecular weight is 300,000) and 60g polyglycolic acid (molecular weight is 80,000). Then vacuum-dry at 45° C. for 24 hours, and add a polylactic acid nucleating agent with a total mass of 0.6 g after drying. Mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm to obtain a mixed raw material C; at an extrusion temperature of 170°C, a screw speed of 50 rpm and a feed rate of 4.0kg / h Next, the mixed raw material C and 200g polylactic acid (molecular weight: 300,000) are melted and compounded by two medical catheter precision extruders to co-extrude the double-layer composite tube (the mixed raw material C is in the inner layer, and the raw material A is in the middle layer), Clean the surface of the double-layer composite tube, and then fumigate and sterilize it with ethylene peroxide before use; use chloroform as a solvent, make chit...

Embodiment 2 3

[0040] Example 2 Preparation of three-layer degradable medical composite catheter

[0041] Take 140g polylactic acid (molecular weight: 300,000) and 60g polycaprolactone (molecular weight: 80,000). Then vacuum-dry at 45° C. for 24 hours, and add a polylactic acid nucleating agent with a total mass of 0.6 g after drying. Mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm to obtain a mixed raw material C; at an extrusion temperature of 170°C, a screw speed of 50 rpm and a feed rate of 4.0kg / h Next, the mixed raw material C and 200g polylactic acid (molecular weight: 300,000) are melted and compounded by two medical catheter precision extruders to co-extrude the double-layer composite tube (the mixed raw material C is in the inner layer, and the raw material A is in the middle layer), Clean the surface of the double-layer composite tube, and then fumigate and sterilize it with ethylene peroxide before use; use chloroform as a solvent, make chitin in...

Embodiment 3 3

[0042] Example 3 Preparation of three-layer degradable medical composite catheter

[0043] Take 120g polylactic acid (molecular weight: 300,000) and 80g polycaprolactone (molecular weight: 80,000). Then vacuum-dry at 45° C. for 24 hours, and add a polylactic acid nucleating agent with a total mass of 0.6 g after drying. Mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm to obtain a mixed raw material C; at an extrusion temperature of 180°C, a screw speed of 50 rpm and a feed rate of 4.0kg / h Next, the mixed raw material C and 200g polylactic acid (molecular weight: 300,000) are melted and compounded by two medical catheter precision extruders to co-extrude the double-layer composite tube (the mixed raw material C is in the inner layer, and the raw material A is in the middle layer), Clean the surface of the double-layer composite tube, and then fumigate and sterilize it with ethylene peroxide before use; use chloroform as a solvent, make chitin in...

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Abstract

The invention discloses a degradable medical composite conduit containing a functional nano coating and a preparation method thereof, which is characterized in that the composite conduit is in a three-layer structure, wherein an inner layer and a middle layer are formed through the melt extrusion compounding by a medical-conduit precision extruder, an outer layer is formed by spraying a degradable high-molecular material dissolved with an effective quantity of active medicaments to the outside of a double-layer composite pipe, and the thickness of the outer layer does not exceed 300nm. The conduit not only overcomes the deficiencies of a metal medical conduit, but also well controls the medicament releasing speed and the conduit degrading speed through a composite structure, is mainly applied to the interventional therapies of trachea, bronchus, esophagus, alimentary canals, bile ducts, nasolacrimal ducts and the like and has broad application prospect.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to a degradable medical composite catheter containing a functional nano-coating and a preparation method thereof, which can be used for continuous production of degradable medical catheters. Background technique [0002] At present, as many as 8 million tons of medical polymer materials are consumed in the world every year. Among them, the amount of medical polymer materials in my country is estimated to be about 1 million tons, which are mainly used to prepare medical device products. According to the dosage, it is polyvinyl chloride (PVC), polyethylene (PE), polystyrene (PS), polypropylene (PP), polyethylene terephthalate (PET), acrylonitrile-butadiene-benzene Ethylene copolymer (ABS) and polycarbonate (PC), etc. These materials all come from non-renewable resource petroleum, which cannot be degraded by themselves after being discarded, pollute the environment and endang...

Claims

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Application Information

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IPC IPC(8): A61M39/00A61L29/16A61L29/12A61L29/14A61L29/06
Inventor 任天斌黄超李建波贾梦虹
Owner 苏州同科生物科技有限公司
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