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Probiotics-containing female hygienic product as well as preparation method and application thereof

A hygienic product and probiotic technology, which is applied in the field of feminine hygiene products and its preparation, to achieve the effects of prolonging the shelf life, good antibacterial effect, and strong acid resistance

Inactive Publication Date: 2011-07-13
BIOGROWING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] One of the technical problems to be solved by the present invention is to provide a probiotic with a high survival rate under humid conditions and a strong adhesion ability to be transported into the urogenital system in view of the problems existing in the existing female hygiene products with active probiotics feminine hygiene products with probiotics

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Production of Sanitary Napkins Containing Probiotics

[0041] 1. Preparation of medium for Lactobacillus rhamnosus and Lactobacillus casei: glucose 1-2%, beef extract 0.5-1%, peptone 0.5-1%, yeast extract 0.5-1%, diammonium citrate 0.1-0.5% , anhydrous sodium acetate 0.1-0.5%, dipotassium hydrogen phosphate 0.05-0.2%, magnesium sulfate 0.05-0.2%, manganese sulfate 0.01-0.3%, Tween 0.01-0.1% and the rest distilled water, pH 6-7 medium Expand the culture and collect the sludge.

[0042] According to the ratio of excipient: bacteria slime = 1.0:0.1-100, the bacteria sludge and excipients are thoroughly mixed. The excipients are lactose 0.5-10%, trehalose 0.5-10%, glycerin 0.1-5%, maltodextrin 0.5-10%, and triglyceride 0.5-10% by weight. Pre-freeze at -40-60°C for 3-10 hours, freeze-dry for 12-24 hours under the condition of -40-60°C and 0.1-1.0Pa to obtain Lactobacillus rhamnosus powder and Lactobacillus casei powder.

[0043] 2. Weigh Lactobacillus rhamnosus powder and...

Embodiment 2

[0046] Production of tampons containing probiotics

[0047] 1. Make Lactobacillus gasseri powder and Lactobacillus fermentum powder, the specific method is the same as step 1 in Example 1;

[0048]2. Weigh Lactobacillus gasseri powder and Lactobacillus fermentum powder according to the mass ratio of Lactobacillus gasseri powder and Lactobacillus fermentum powder to 1.0:0.1-10, mix them evenly, dissolve them with sterile water to obtain a bacterial suspension, and The total number of live bacteria in the liquid is 1×10 9 ~10 12 cfu / ml.

[0049] 3. Soak the absorbent core of the tampon (that is, the surface layer between the surface layer and the absorbent layer) in the bacterial suspension. Drying the surface layer yields the finished product.

Embodiment 3

[0051] Production of toilet paper containing probiotics

[0052] 1. Make Lactobacillus gasseri powder and Lactobacillus fermentum powder, the specific method is the same as step 1 in Example 1;

[0053] 2. Weigh Lactobacillus gasseri powder and Lactobacillus fermentum powder according to the mass ratio of Lactobacillus gasseri powder and Lactobacillus fermentum powder to 1.0:0.1-10, mix them evenly, dissolve them with sterile water to obtain a bacterial suspension, and The total number of live bacteria in the liquid is 1×10 9 ~10 12 cfu / ml.

[0054] 3. Spray the above bacterial suspension with a spray machine on the running toilet paper surface that is about to be dried (drying temperature is lower than 45°C). Then use ordinary toilet paper to cut and pack.

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PUM

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Abstract

The invention discloses a probiotics-containing female hygienic product, comprising a carrier; a probiotics composition is attached onto the carrier and comprises lactobacillus and an excipient, wherein the excipient is combined with polysaccharide or lipid substances; and the viable count of a unit product is 107-1012CFU. The invention further discloses a preparation method of the probiotics-containing female hygienic product. The active probiotics or variants thereof in the invention can adhere to a female vagina and breed in a fixed way, and the selected bacterial strains belong to single strain or combination of strains of lactobacillus casei, lactobacillus rhamnosus, lactobacillus gasseri, lactobacillus fermentium and bacteroides fragilis, and can be used for treating or preventing bacterial vaginosis, candidal vaginitis, HIV (Human Immunodeficiency Virus) infectious diseases, chlamydia infectious diseases, infectious diseases endangering a fetus of a pregnant woman, premature-birth infectious diseases, and urinary tract infectious diseases. The preparation method provided by the invention is simple and economic and is beneficial to product storage.

Description

field of invention [0001] The invention relates to a feminine hygiene product and its preparation method and use, in particular to a female hygiene product with active probiotics and its preparation method and use. Background technique [0002] Lactobacillus is the dominant bacteria in the vagina of healthy women, which can prevent bacterial vaginosis and urinary system infection by inhibiting the number of other microorganisms in the vagina. Studies have shown that the protective mechanism of this lactobacillus to maintain vaginal health mainly includes the following aspects: ①Metabolize glycogen to produce lactic acid and maintain vaginal pH acidity; ②Through adhesion, form a bacterial film on vaginal epithelial cells for space-occupying protection; ③Inhibit the growth of pathogenic microorganisms by producing hydrogen peroxide or bacteriocins. [0003] Women's microbiome is disturbed due to hygienic conditions, seasonal changes, and hormonal fluctuations caused by pregna...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61K35/74A61K9/19A61K47/36A61P13/02A61P15/02A61P31/04A61P31/10A61P31/18A61K35/747
Inventor 马霞刘帅宋锦安闫屹泓
Owner BIOGROWING CO LTD
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