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Biomedical material having porous calcium phosphate-collagen composite coating and preparation method of biomedical material

A biomedical material, porous calcium phosphate technology, applied in coatings, medical science, prostheses, etc., can solve problems such as brittle fracture or peeling, unusable bearing parts, insufficient mechanical properties, etc., to promote cell adhesion, Reducing the dosage and maintaining the effect of mechanical properties

Inactive Publication Date: 2011-08-10
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

The HA crystals deposited on the collagen nanomaterials obtained through the biomimetic technology reaction are similar to the structure of bone, but its mechanical properties are insufficient and cannot be used for bearing parts
On the surface of metal materials, it is mostly used to soak the metal in Na 2 HPO 4 , Ca(OH) 2 Precalcification in supersaturated solution, and then introduce collagen into simulated body fluid to form hydroxyapatite / collagen composite coating (Yang Xianjin, Cui Zhenduo, Cai Yanli et al., Chemical preparation method of hydroxyapatite / collagen composite coating on nickel-titanium alloy surface Patent publication number: 200510133632.6), or Ca(NO 3 ) 2 , NH 4 h 2 PO 4 and type I collagen to form hydroxyapatite / collagen composite coatings on metal surfaces by electrochemical methods (S.Manara, F.Paolucci, B.Palazzo et al. Electrochemically-assisted deposition of biomimetic hydroxyapatite-collagen coatings on titanium plate.J Inorganica Chimica Acta, 2008; 361; 1634-1645), but its disadvantages are that the preparation process is complex and the toughness of the interface is poor, the thickness of the coating is not enough, and it is prone to brittle fracture or peeling under impact load or thermal shock

Method used

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  • Biomedical material having porous calcium phosphate-collagen composite coating and preparation method of biomedical material
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  • Biomedical material having porous calcium phosphate-collagen composite coating and preparation method of biomedical material

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preparation example Construction

[0055] The invention provides a method for preparing a biomedical material with a porous calcium phosphate-collagen composite coating. The method is based on plasma spraying to prepare a porous calcium phosphate coating, and directly compound a collagen surface layer on the surface of the porous coating. .

[0056] The specific operation steps are:

[0057] A preparation of porous calcium phosphate coating

[0058] According to the calcium-phosphorus molar ratio of hydroxyapatite, tricalcium phosphate, etc., add the diammonium hydrogen phosphate aqueous solution with a molar concentration of 1.2-3.6 mol / L dropwise to calcium nitrate with a molar concentration of 1-3 mol / L under constant stirring In the aqueous solution, keep the reaction liquid at 30-90°C, control its pH at 9-12 with ammonia water with a concentration of 10%-30% by mass percentage, let it stand for 5-15 minutes after the reaction, and then age for 24-48 hours, add commonly used pore forming agent (such as de...

Embodiment 1

[0065] Embodiment 1 The preparation of the biomedical material with porous calcium phosphate-collagen composite coating of the present invention

[0066] Press Ca 10 (PO 4 )6 (OH) 2 The molar ratio of calcium to phosphorus (1.67), under constant stirring, the 2.8mol / L diammonium hydrogen phosphate aqueous solution is added dropwise in the 2.4mol / L calcium nitrate aqueous solution, and the reaction solution is kept at 70°C, and the concentration is 25% by mass percentage. Ammonia water was used to keep the pH at 10.5. After the reaction, it was allowed to stand for 10 minutes, and then aged for 24 hours to obtain a hydroxyapatite suspension with a solid content of 34%. Then add the pore-forming agent deionized water to the hydroxyapatite suspension, and dilute it into a hydroxyapatite suspension with a solid content of 17% for later use. Using plasma spraying equipment, the nozzle adopts atomizing nozzle, and the liquid plasma spraying method is used, on the biomedical titan...

Embodiment 2

[0067] Example 2 Preparation of Biomedical Materials with Porous Calcium Phosphate-Collagen Composite Coating in the Present Invention

[0068] Press Ca 10 (PO 4 ) 6 (OH) 2 The molar ratio of calcium to phosphorus (1.67), under constant stirring, the diammonium hydrogen phosphate aqueous solution with a molar concentration of 2.8mol / L is added dropwise to the calcium nitrate aqueous solution with a molar concentration of 2.4mol / L, and the reaction solution is kept at 70°C. Ammonia water with a mass percentage concentration of 25% was used to control the pH at 10.5, and after the reaction, it was allowed to stand for 10 minutes, and then aged for 24 hours to obtain a hydroxyapatite suspension with a solid content of 34%. The pore-forming agent deionized water was added to the hydroxyapatite suspension, and it was diluted to form a hydroxyapatite suspension with a solid content of 17% for later use. Utilize the plasma spraying equipment, the nozzle adopts the atomizing nozzl...

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Abstract

The invention relates to the field of biomedical material. The main technical problem to be solved is that the osteogenesis activity of calcium phosphate bioactivity coating needs to be further improved. The technical scheme of the invention for solving the above technical problem is to provide a biomedical material having porous calcium phosphate-collagen composite coating, which can promote cell adhesion, proliferation and differentiation effectively and simultaneously has superior mechanical properties, and a preparation method of the biomedical material. According to the invention, the new biomedical material is obtained by directly compositing a collagen surface layer on the surface of the calcium phosphate bioactivity coating. The biomedical material can not only speed the bone formation up and promote the early fixation of implant, but also can load osteogenesis-promoting growth factors and polypeptides on the collagen surface layer to further strengthen the osteogenesis-inducing ability and accelerate the early growing of bone. The biomedical material of the invention is simple in process and low in product cost, can improve the safety and the success rate of existing implants to a large extent, and promote the early rehabilitation of patients.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a biomedical material with a porous calcium phosphate-collagen composite coating that can effectively promote cell adhesion, proliferation and differentiation, accelerate new bone formation and has good mechanical properties and its preparation method. Background technique [0002] Calcium phosphate bioceramic coatings prepared on the surface of titanium alloys are widely used as replacement materials for artificial joints, dental implants and other bearing bone repairs because of their excellent mechanical properties of metal matrix materials and good biological activity of calcium phosphate coatings. With the aging of joint replacement patients, higher requirements are placed on the osteogenic activity of the implanted device surface to accelerate early bone ingrowth and promote early healing of the prosthesis and bone. [0003] Collagen is the main organic component of natur...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/32A61L27/54
Inventor 吴方何静黄涛甘露田志立吴尧
Owner SICHUAN UNIV
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