Ophthalmic medicine-carried amnion and preparation method thereof

Abstract

The invention provides an ophthalmic medicine-carried amnion which comprises fibrin glue, fresh amnion or preserved amnion. The ophthalmic medicine-carried amnion is further characterized by comprising gatifloxacin-carried chitosan nanoparticles. A preparation method of the ophthalmic medicine-carried amnion comprises the steps of: preparing gatifloxacin-carried chitosan nanoparticles suspension liquid, preparing gatifloxacin-carried chitosan nanoparticles dry powder and preparing medicine-carried amnion. The gatifloxacin, the chitosan nanoparticles, the fibrin glue and the amnion can mutually play a role in synergetic beneficiation and multiple slow release, and can prolong the release of the contained medicine, so that the medicine is more durable in local effective concentration after the use of the amnion, and the medicine can not be frequently used; and the invention has the advantages of being low in allergic reaction rate, good in histocompatibility, free of side effects, capable of being absorbed gradually, healing the wound and filling in gaps, good for healing the wound, and capable of withdrawing a medicine slow release carrier without operation and the like.

Description

technical field [0001] The invention belongs to medical application or transplantation biomaterials, in particular to a drug-loaded amniotic membrane used in ophthalmology and a preparation method thereof. Background technique [0002] Ocular surface diseases, including pterygium, keratitis, corneal perforation, ocular surface chemical burns, and ocular surface trauma, are common diseases in ophthalmology, often leading to vision loss in patients. It is of great significance to take active and effective treatment measures for it in the work of preventing and curing blindness. The conventional treatment method is eye drops or eye drops combined with surgical application or transplantation of new membranous materials to repair the ocular surface; currently, the biomaterials used for the ocular surface are mainly amniotic membranes, and simple amniotic membrane application or transplantation can be difficult during the operation. There is a characteristic of being easy to curl...

AI Technical Summary

Problems solved by technology

At present, there are many studies on: 1. Preparation of drugs into nano-medicines to improve the penetration of drugs on the ocular surface and the residence time of drugs on the ocular surface, but there is still the problem of frequent drops of drugs in nano-ophthalmics; The drug storage system is to put the drug on a certain carrier, and achieve the purpose of treatment through the release of the drug, but the general carrier cannot bear the pulling of the surgical suture because it is not a bioactive film, and is not easy to fix on the ocular surface

In the prior art, there is a Chinese invention patent application titled "drug amniotic membrane and its preparation method" published on September 26, 2007 (CN101040616A). The drug amniotic membrane contains exogenous cell growth factors, and its preparation method It is prepared by immersing the amniotic membrane in a preservation solution containing exogenous cell growth factors, and then cryopreserved or freeze-dried at a low temperature; it can make the amniotic membrane biologically active after long-term storage, and can also be used to extract the amniotic membrane from the preservation solution. The exogenous cell growth factor absorbed in the medium is slowly released to the wound surface, which is beneficial to wound healing. It is said that it can be used for the repair of ophthalmic wounds; The content of growth factors is unstable, and the amount is not easy to control, and the repeatability is poor. Therefore, it is difficult for the prepared drug amniotic membrane to have a long-term sustained-release effect of the drug