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Medical component and manufacturing method thereof

A manufacturing method and medical technology used in pharmaceutical formulations, pharmaceutical sciences, bone implants, etc.

Active Publication Date: 2011-12-14
PROSTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, unlike the above-mentioned problems, this method has the problem that when these implants are transplanted into the living body, the possibility of infection such as suppuration in the affected area is very high.

Method used

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  • Medical component and manufacturing method thereof
  • Medical component and manufacturing method thereof
  • Medical component and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0072] Using Ti alloy (mass%, 6%Al-4%V-the rest of Ti, JIS 60 alloys), stainless steel (SUS304) as the base material, made a disc (thickness: 2.0mm) as an in vitro (in vitro ) experimental test piece, made of external bone fixation needles for rabbits as a test piece for in vivo experiments. In addition, among these test pieces, the test piece made of Ti alloy was degreased and then anodized. Anodizing treatment is carried out in an acidic electrolyte (liquid temperature: room temperature) in a mixed pool of sulfuric acid (35g / l)-phosphoric acid (25g / l)-hydrogen peroxide (10g / l), electrolysis at a constant voltage (150V) for 5 minutes processing. The initial current density of the applied current is 8A / dm 2 , due to constant voltage electrolysis, the current value gradually decreases with time. In addition, the electric current is a pulse current with a frequency of 1000 Hz. The case where anodic oxidation treatment was not performed was taken as a comparative example.

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Embodiment 2）

[0087]Using stainless steel (SUS 304) as the substrate, prepare disc test pieces (thickness: 2mm) for antibacterial tests. These test pieces were subjected to pickling and cleaning treatment, and then anodized treatment or chemical treatment. The pickling treatment is immersion in a mixed aqueous solution of nitric acid (5%)-hydrofluoric acid (3%) at a liquid temperature of 40°C for 3 minutes. In addition, the anodizing treatment is carried out in an acidic electrolyte solution (liquid temperature: room temperature) in a hydrochloric acid (47% by mass)-hydrogen peroxide (2% by mass)-formalin (10% by mass)-water mixing pool. The test piece was used as an anode, and the pure Ti plate was used as a cathode, and electrolysis was performed at a constant voltage (100V) for 15 minutes. In addition, the applied current was a pulse-like current with a frequency of 3000 Hz. The initial current value is 3.5A / dm 2 . The chemical treatment was a process of immersing for 30 minutes in a...

Embodiment 3）

[0099] Using Co-Cr alloy (mass %: 63.0%Co—6.0%Mo—2.0%Ni—0.25%C—the rest of Cr) as the base material, make a disc test piece for antibacterial test (plate thickness: 5.0mm) . These test pieces were subjected to pickling and cleaning treatment, followed by anodizing treatment.

[0100] Anodizing treatment is potassium hydroxide (165g / l) - potassium fluoride (35g / l) - sodium phosphate (35g / l) - aluminum hydroxide (35g / l) - alkaline electrolyte of water mixing pool (liquid temperature : room temperature), the test piece was used as the anode, and the pure Ti plate was used as the cathode, and electrolytic treatment was performed for 15 minutes at a DC constant voltage (150V). In addition, the applied current was a pulsed current with a frequency of 5000 Hz. The initial current value is 8A / dm 2 .

[0101] For the obtained test pieces, in the same manner as in Example 2, the surface conditions of the thin films (oxidized films) formed on the surfaces of each test pieces were obs...

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Abstract

Provided is a medical part with excellent antibiotic properties and antibiotic substantivity as well as high biocompatibility, and a manufacturing method therefor. After an anodic oxidation treatment, wherein a pulsed current with a frequency of 50 to 10,000 Hz is applied for an electrolytic treatment, is applied to a base material in an acidic electrolytic bath or an alkaline electrolytic bath so as to form a film, which has minute holes and / or minute protrusions and recesses preferably in the quantity of 5 x 104 / mm2 or more on the surface of the base material, an iodine-impregnation treatment is applied so as to impregnate iodine or an iodine compound into said film. Polyvinyl pyrrolidone iodine, ss-cyclodextrin iodine, or silver iodine is desirable for the iodine compound. Furthermore, a biocompatible metallic material selected from Ti, Ti alloy, stainless steel, and Co-Cr alloy is desirable for the base material. The film may be formed by means of a chemical treatment, a thermal treatment, or a machining process, or a combination of these, instead of the anodic oxidation treatment. Thus, a medical part with excellent antibiotic properties and antibiotic substantivity as well as high biocompatibility can be manufactured easily and inexpensively.

Description

technical field [0001] The present invention relates to medical components, and in particular to improving the antibacterial properties of medical components such as artificial bones and artificial joints that are implanted into living bodies and used. Background technique [0002] Due to the advancement of medical technology in recent years, the technology of implanting implants into living organisms has been increasingly applied clinically. bones, joints, etc. As the characteristics required for the implant used in this technology, it is required to have the part of the former organism to be replaced or the equivalent strength, and at the same time, it is firstly required to have compatibility with the organism, that is, to have bio-affinity sex. Examples of biocompatible metal materials having such properties include titanium, titanium alloys, stainless steel, Co—Cr alloys, and the like. However, these metallic materials do not exhibit living activity and are not chemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00
CPCA61L2300/102A61L27/54A61L27/56A61L2300/202A61L2400/18A61L2300/802A61L2300/404A61L2300/104A61L27/04A61L27/50A61L2300/106A61L27/06A61F2/28
Inventor 高谷松文土屋弘行前岛正受
Owner PROSTEC
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