Green synthesis method for ibuprofen piconol and medicinal preparation thereof

A green synthesis technology of ibuprofen pyridoxine, which is applied in the field of western medicine, can solve the problems of non-recycling, high production cost, and unfriendly environment, and achieve the effects of less three wastes, eliminating troublesome disposal, and easy control of reaction conditions
CN102304081AInactive Publication Date: 2012-01-04湖南医药工业研究所有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
湖南医药工业研究所有限公司
Publication Date
2012-01-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a green synthesis method for ibuprofen piconol and a medicinal preparation method thereof and provides a formula process of and a green chemical synthesis method of a medicinal compound, in particular the method for preparing ibuprofen piconol, a medicinal composition prepared by using ibuprofen piconol as an active ingredient, and a new formula of an externally-applied preparation for diminishing inflammation, relieving pain and treating infectious diseases. Compared with the prior art, the method has the advantages that: the technical route is advanced, the technical conditions are reasonable, the use of halogenating agents such as thionyl chloride which produce lots of toxic and harmful gases is avoided, a reactions are replaced by one reaction, the operation is simple, convenient and safe, the reaction yield is high, the reaction conditions are easy to control, the solvent and a dehydration condensation agent can be recycled and reused, the problems of trouble of treatment after a reaction process, serious waste gas, waste water and waste residue pollution and the like in the conventional process are solved from the source, environment pollution is avoided, little waste gas, waste water and water residue are produced, and high implementation value and great social and economic benefit are realized.
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Description

technical field

[0001] The present invention relates to the field of western medicine invention, and relates to a pharmaceutical compound formulation process and green chemical synthesis, specifically a method for preparing a compound with the following structural formula, and a pharmaceutical composition containing the compound as an effective active ingredient.

[0002] Background technique

[0003] Ibuprofen is an aryl alkanoic acid compound with anti-inflammatory, analgesic and antipyretic effects. Since its listing in the late 1970s, ibuprofen has developed rapidly and has become one of the anti-inflammatory, antipyretic and analgesic drugs with the largest production and usage, and has been accepted by patients.

[0004] Ibuprofen pyridoxine is a derivative of ibuprofen, which belongs to the external use of non-steroidal anti-inflammatory analgesics for dermatology treatment. Ibuprofen pyridoxine has strong analgesic and anti-inflammatory effects, minimal toxic and...

Claims

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