Cockroach extract, preparation method thereof, and application of cockroach extract preparation in treatment of cardiovascular disease

A technology of extracts and cockroaches, which can be used in cardiovascular diseases, medical raw materials derived from arthropods, anti-inflammatory agents, etc., can solve the problems that the application potential of cockroach extracts needs to be further developed and utilized, and improve microcirculation , reduce pulmonary artery pressure, increase the effect of coronary flow

Active Publication Date: 2012-02-15
YUNNAN TENGCHONG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern scientific research shows that cockroach extract has strong biological activity, but there are still great limitations in the applicatio

Method used

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  • Cockroach extract, preparation method thereof, and application of cockroach extract preparation in treatment of cardiovascular disease
  • Cockroach extract, preparation method thereof, and application of cockroach extract preparation in treatment of cardiovascular disease

Examples

Experimental program
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Example Embodiment

[0019] The preparation method of the described cockroach extract further comprises:

[0020] A. In the oil-water separation step, after the alcohol-extracted thick paste is introduced into the oil-water separator, 4 to 6 times by weight of purified water is added and fully stirred. After standing until the stratification is obvious, the bottom sediment and the upper layer of grease are removed, and the middle layer of brown medicine is collected. liquid;

[0021] B. In the upper column separation step, the Chinese medicinal liquid is added with activated carbon for medical injection with a particle size of 200 to 325 mesh, fully stirred and left for 1 to 2 hours, until the medicinal liquid is adsorbed to be colorless and then packed into a column, the liquid is drained, and water-saturated positive carbon is added. Butanol or phenol aqueous solution with a concentration of 5-10% is eluted, and the eluted medicinal solution is collected and eluted until the color of the medicin...

Example Embodiment

[0068] Example 1

[0069] Take 1000 g of cockroach dried worm body coarse powder, add 5 L of 90% ethanol to soak for 48 hours, then use 90% ethanol as a solvent to slowly permeate until the filtrate is slightly yellow, and the filtrate is concentrated under reduced pressure to obtain a thick paste, and ethanol is recovered at the same time; After the alcohol-extracted thick paste is introduced into the oil-water separator, 4 times by weight of purified water is added and fully stirred, and after standing until the layers become obvious, the bottom sediment and the upper layer of grease are removed, and the middle layer of brown liquid is collected; the liquid is added with a particle size of 200~ 325-mesh activated carbon for medical injection, fully stirred and then rested for 1 hour, until the liquid was adsorbed to colorless, then loaded into a column, the liquid was drained, and water-saturated n-butanol was added to elute, and the eluted liquid was collected and eluted to ...

Example Embodiment

[0071] Example 2

[0072] Take 1000 g of cockroach dried worm body coarse powder, add 10 L of 95% ethanol to soak for 60 hours, then use 95% ethanol as a solvent to slowly permeate until the filtrate is slightly yellow, and the filtrate is concentrated under reduced pressure to obtain a thick paste, and ethanol is recovered at the same time; After the thickening paste was introduced into the oil-water separator, 6 times by weight of purified water was added and fully stirred. After standing until the layers became obvious, the bottom sediment and the upper layer of grease were removed, and the brown liquid in the middle layer was collected; Activated carbon for injection, stir well and stand still for 2 hours, until the liquid is adsorbed to be colorless, then load the column, drain the liquid, add 5% phenol aqueous solution to elute, collect the eluted liquid, and elute to the color of the liquid No deeper than No. 4 yellow colorimetric solution; the eluted medicinal solution...

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Abstract

The invention provides a cockroach extract, a preparation method thereof, and application of a cockroach extract preparation in treatment of cardiovascular disease. The cockroach extract comprises the following components (based on dry weight): 20-40% of composite nucleoside base, 30-60% of associated amino acid, 2-4% of uracil, 3-6% of hypoxanthine and 5-10% of inosine. The preparation method comprises the following steps of: pulverizing dried cockroach into coarse powder, carrying out percolation or reflux extraction with 90-95% ethanol to obtain dense paste, carrying out oil-water separation, and removing precipitate and oil to obtain water-layer drug liquid; and adsorbing with activated carbon, carrying out secondary alcohol extraction and water extraction, decolorizing, carrying out ultrafiltration and concentrating to obtain the cockroach extract dense paste. Combined with proper pharmaceutical auxiliary materials, the cockroach extract can be prepared into aqueous injection, freeze-dried powder injection, capsules, granules, tablets, oral liquid, dropping pills and other various dosage forms, and the obtained preparation can be used for treating cardiovascular disease, particularly heart failure caused by pulmonary heart disease, cardiomyopathy, rheumatism, coronary disease, high-altitude heart disease and the like.

Description

technical field [0001] The invention belongs to the technical field of biological extraction and pharmacy, further belongs to the technical field of cockroach extraction and pharmacy, and specifically relates to a cockroach extract and its preparation method and its application in treating cardiovascular diseases. Background technique [0002] The cockroach, also known as the American cockroach (commonly known as the cockroach), is the largest in the family Blatella, with an adult body length of 29-35 mm. The epidermis of the cockroach contains sclera and chitin, elements such as bromine, zinc, nickel, manganese, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, and magnesium. Thirteen kinds of amino acids can be obtained by hydrolysis of the muscles, and there are also micronutrients stored in the body. Vitamins B1, B2, niacin and ascorbic acid, etc. Lymph contains trehalose, trehalase, glycoprotein, inositol, protocatechuic acid glucoside, etc.; the whole ...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P9/00A61P9/04A61P9/10A61P29/00A61K31/7076A61K31/522A61K31/513
Inventor 李筱玲邵维在万德生段兆炜周应硕
Owner YUNNAN TENGCHONG PHARMA FACTORY
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