Surface-controlled polymerization modified biological material and preparation method thereof

A technology of biomaterials and polymer layers, applied in the field of biomaterials modified by surface controllable polymerization and its preparation, can solve the problems of toxic initiator halides, high cost of ligands, difficult storage, etc., and achieve simplified methods and reaction conditions Simplified, non-toxic effects

Active Publication Date: 2013-06-19
南京周宁琳新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are still two disadvantages in ATRP: ①The initiator halide used is poisonous; ②The metal catalyst in the reduced state is sensitive to oxygen or moisture and is not easy to store
[0005] However, in the conventional RATRP reaction, 2,2'bipyridine (bpy) is generally used as the ligand, which has problems such as high cost and toxicity of the ligand.

Method used

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  • Surface-controlled polymerization modified biological material and preparation method thereof
  • Surface-controlled polymerization modified biological material and preparation method thereof
  • Surface-controlled polymerization modified biological material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Add 10 pieces of silicone rubber diaphragm to 0.5% (wt%) silane coupling agent chloromethyltriethoxysilane aqueous solution, and magnetically stir for 6 hours. Take it out and vacuum dry at 110°C for 24 hours to obtain a silanized silicone rubber diaphragm. Put the silanized silicone rubber membrane and 15 mL of secondary water into a three-necked flask, and add 0.02 mL of benzoyl peroxide initiator, and magnetically stir for 10 min at room temperature. Put the silicone rubber film with the benzoyl peroxide initiator fixed on the surface into the aqueous solution of 1 mol / L ammonium phosphate zwitterionic monomer (R is methacrylate type), and add CuCl 2 And the silane coupling agent chloromethyl triethoxy silane ligand, the ratio of the amount of its substance is: M Zwitterion : M CuCl2 : M Chloromethyltriethoxysilane =120:5:11, then pass in nitrogen protection. The reaction was stirred at room temperature for 72h. Take out the membrane, wash it with a large amount o...

Embodiment 2

[0052] Add 10 pieces of silicone rubber diaphragm to 0.05% (wt%) silane coupling agent chloromethyltrimethoxysilane aqueous solution, and magnetically stir for 3h. Take it out and vacuum dry at 110°C for 24 hours to obtain a silanized silicone rubber diaphragm. Put the silanized silicone rubber membrane and 5 mL of secondary water into a three-necked flask, and add 0.004 mL of tert-butyl hydrogen peroxide initiator, and magnetically stir for 5 min at room temperature. Put the silicone rubber film with tert-butyl hydrogen peroxide fixed on the surface into the methanol aqueous solution of 0.1 mol / L ammonium phosphate zwitterionic monomer (R is methacrylate type), and add CuBr 2 And the silane coupling agent chloromethyltrimethoxysilane ligand, the ratio of the amount of substance is: M Zwitterion : M CuBr2 : M Chloromethyltrimethoxysilane =90:3:7, then pass in nitrogen protection. The reaction was stirred at room temperature for 1 h. Take out the membrane, wash it with a lar...

Embodiment 3

[0054] Add 10 polyurethane membranes to 0.08% (wt%) silane coupling agent dichloromethyltrimethoxysilane aqueous solution, and magnetically stir for 4h. Take it out and vacuum dry at 110°C for 24 hours to obtain a silanized polyurethane film. Put the silanized polyurethane film and 6 mL of secondary water into a three-necked flask, and add 0.004 mL of tert-butyl hydrogen peroxide initiator, and magnetically stir for 5 min at room temperature. Put the polyurethane film with tert-butyl hydrogen peroxide fixed on the surface into 0.2 mol / L sulfa zwitterionic monomer (R is methacrylate type) aqueous solution, and add CuBr 2 And the silane coupling agent dichloromethyl trimethoxy silane ligand, the ratio of the amount of substance is: M Zwitterion : M CuBr2 : M Dichloromethyltrimethoxysilane =95:3:7, then pass in nitrogen protection. The reaction was stirred at room temperature for 6h. Take out the membrane, wash it with a large amount of secondary water, and dry it in vacuum.

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Abstract

The invention relates to a surface-controlled polymerization modified biological material which comprises a biological material matrix and is characterized in that after the silanization processing is carried out on the biological material, a 'brush'-shaped amphoteric ion polymer layer is grafted on the surface of the biological material. A RATARP (Reverse Atom Transfer Radical Polymerization) complex catalysis system comprising a silane coupling agent and copper halide is adopted by the invention, which is different from 2, 2'- bipyridine (Bpy) ligand adopted in the conventional RATARP (Reverse Atom Transfer Radical Polymerization) reaction, wherein the silane coupling agent is used as the coupling agent and simultaneously is used as a ligand to participate in the RATARP (Reverse Atom Transfer Radical Polymerization) reaction; and a amphoteric ion monomer is grafted on the surface of the biological material through the RATARP (Reverse Atom Transfer Radical Polymerization). According to the invention, the specificity and the functionality of adsorption protein on the surface of the biological material can be effectively regulated and controlled, and the adherence of blood cells and the multi-way activation of blood are inhibited, thereby obtaining the biological material with excellent blood compatibility. The invention also discloses the preparation method of the biological material.

Description

Technical field [0001] The present invention relates to a biological material and a preparation method thereof, in particular to a biological material with a surface controllable polymerization modification and a preparation method thereof, using a new RATRP catalytic system, in which a silane coupling agent not only plays the role of a coupling agent, but also Participating in the RATRP reaction as a single ligand, grafting zwitterionic monomers to the surface of polymer materials realizes the "active" controllable polymerization of zwitterions, and finally obtains biological materials with excellent blood compatibility. Background technique [0002] With the development of biomedicine, the application of biomaterials has become more and more extensive and important. At present, for most medical materials, when it comes into contact with living tissues, it will cause some important reactions, such as the formation of thrombus and some undesirable immune reactions. Biocompatibil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/16C08J7/12C08L83/04C08L75/04C08L23/06C08L27/06C08L27/18A61L33/06
Inventor 周宁琳陆春燕徐东沈健汤毅达金素星
Owner 南京周宁琳新材料科技有限公司
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