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A kind of chrysanthemum total flavonoids self-emulsifying system composition and application thereof

A technology of total flavonoids and self-emulsification, which is applied in the field of medicine, can solve the problems of unsatisfactory bioavailability of common preparations, poor water solubility of total flavonoids from chrysanthemums, and no total flavonoids from chrysanthemums. It achieves large boundary area, good stability and improved curative effect Effect

Active Publication Date: 2014-10-08
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total flavonoids of chrysanthemum are poor in water solubility, which affects the absorption in the body. The bioavailability of common preparations is not ideal. If the self-emulsifying drug delivery system is applied to chrysanthemum flavonoids, the bioavailability can be significantly improved
There is no public report on the self-emulsification technology of chrysanthemum total flavonoids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 5.5g of Cremophor-EL-40, 2.5g of 1,2-propanediol and mix well, add 1g of ethyl oleate and mix well to obtain a self-emulsifying matrix; then weigh 1.0g of chrysanthemum total flavonoids extract, 20g of dextrin, 10g of starch is passed through 80 mesh sieve respectively, added to the above self-emulsifying matrix, ground and mixed evenly, passed through 20 mesh sieve to granulate, dried in a blast oven at 60°C, granulated with 18 mesh sieve, filled into empty capsule shells, and the total chrysanthemum is obtained. Flavonoid self-emulsifying hard capsules.

[0023] The dissolution of the prepared chrysanthemum total flavonoids self-emulsifying capsules and common chrysanthemum total flavonoids capsules were compared according to the third method of the dissolution test method of "Chinese Pharmacopoeia" 2010 edition (two), and the results showed that the self-emulsifying hard capsules were The drug release rate was 42% within 5 minutes, 55% within 10 minutes, and 68...

Embodiment 2

[0027]Weigh 470g of Cremophor-EL-40, 200g of 1,2-propanediol and mix well, add 250g of ethyl oleate, mix well to obtain a self-emulsifying base; then weigh 80g of chrysanthemum total flavonoid extract, add it to the above self-emulsifying base and mix evenly , made into the soft capsule content, and the soft capsule content is transported to the storage tank of the soft capsule machine with a delivery tube. Get 348g of gelatin, 139g of glycerin, and 313g of water to prepare a gelatin solution, transport it to the gel storage tank of the soft capsule machine with a delivery tube and keep it warm (60°C). Open the soft capsule machine, press the capsule skin, adjust the pressure of the capsule skin and the content of the content, control the mass ratio of the capsule skin and the content to 0.66:1, and inject the contents of the capsule skin into the capsules pressed into the capsule skin And sealed tightly, the chrysanthemum total flavonoids self-emulsifying soft capsules were o...

Embodiment 3

[0030] Weigh 5g of Tween-80, 3g of 1,2-propanediol and mix well, add 1.5g of ethyl oleate, mix well to obtain a self-emulsifying base; weigh 0.5g of chrysanthemum total flavonoids extract, 20g of starch, add the above self-emulsifying Mix well in the matrix, pass through a 18-mesh sieve to granulate, oven-dry at 70°C, granulate through a 16-mesh sieve, mix evenly with 0.45 g of magnesium stearate, and press into tablets to obtain self-emulsifying tablets of chrysanthemum total flavonoids. Measure the dissolution rate according to the method of Example 1. As a result, the self-emulsifying tablet releases 38% of the drug in 5 minutes, 50% of the drug in 10 minutes, and reaches the maximum dissolution rate of 75% in 60 minutes. . The common tablet releases 2.5% of the drug within 5 minutes and 8% of the drug within 10 minutes. The maximum dissolution rate is only 48%.

[0031] The common chrysanthemum total flavonoids tablet is prepared as follows: Weigh 12.5g chrysanthemum tot...

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Abstract

The invention provides a chrysanthemum total flavone self-emulsifying system composition. The chrysanthemum total flavone self-emulsifying system composition comprises the following components: chrysanthemum total flavone extract, oil phase, emulsifier and auxiliary emulsifier, and the mass percents of all the components are as follows: the chrysanthemum total flavone extract accounts for 0.5 to 20 percent, the oil phase accounts for 10 to 40 percent, the emulsifier accounts for 35 to 60 percent, and the auxiliary emulsifier accounts for 10 to 40 percent. The chrysanthemum total flavone self-emulsifying system composition can be prepared into a chrysanthemum total flavone self-emulsifying preparations with other pharmaceutical accessories acceptable to a human body, and the chrysanthemum total flavone self-emulsifying preparations are procyanidin self-emulsifying hard capsules, tablets or soft capsules. Compared with other common tablets and capsules, the procyanidin self-emulsifying preparations can enable the drugs to be dissolved more quickly, and the micron-sized emulsion droplets formed by the procyanidin self-emulsifying preparations have larger interfacial area, so that absorption can be increased, and the therapeutic effect can be enhanced.

Description

(1) Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a self-emulsifying system composition of chrysanthemum total flavonoids and its use for preparing chrysanthemum total flavonoid self-emulsifying preparations. (2) Background technology [0002] Chrysanthemum is the dry flower head of Chrysanthemum morifoLium Ramat, a perennial herb of the genus Chrysanthemum in the family Asteraceae. Chrysanthemum is a commonly used traditional Chinese medicine, which has the effects of nourishing the liver and improving eyesight, calming and lowering liver yang, clearing heat and detoxifying. Its main chemical components include flavonoids, volatile oils, chlorogenic acids, etc. Flavonoids include luteolin-7-glucoside, apigenin-7-O-glucoside, locustside, apigenin, apigenin-7-O -rhamnoglucoside, acaciacetin-7-O-glucoside, quercetin-3-O-galactoside, luteolin-7-O-rhamnoside, luteolin-7-O-ratin Plum glucoside, luteolin, etc. Chry...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/107A61K9/20A61K9/48A61K47/34A61K47/44A61K36/287A61P9/10A61P39/06A61K133/00A61K131/00
Inventor 单伟光唐岚黄金龙殷之武于海宁施存元计燕萍俞鑫亚
Owner ZHEJIANG UNIV OF TECH