Method for preparing water-soluble lutein

A lutein and water-soluble technology, which is applied in the field of preparing water-soluble lutein, can solve the problems of reducing the content of all-trans isomers, affecting the biological activity of products, and reducing the quality of lutein, so as to ensure water solubility and stability Improve and avoid the effect of secondary reprocessing

Inactive Publication Date: 2012-07-18
青岛赛特生物科技有限公司
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Problems solved by technology

[0005] The Chinese invention patent with publication number 101177540 discloses "a preparation method of food-grade lutein water-soluble dry powder". Boiling point, volatile and highly soluble organic solvents for lutein crystals are mixed, heated and dissolved at a temperature below 100°C, then added to the water phase substance, stirred evenly, homogenized under high pressure, and spray-dried to obtain the finished product. This method uses a large amount of organic Solvents are easy to cause solvent residues, and solvent recovery is difficult, which affects the quality of lutein
[0006] The Chinese invention patent with the publication number of 1348483 discloses "a lutein-stabilized water dispersion and a stable water-dispersible dry powder, and its preparation and application", the method uses protein hydrolyzate and gelatin as protection The high boiling point solvent isopropanol is mixed with lutein crystals, and instantaneous high temperature and high pressure equipment is used. The process temperature can reach 240°C, resulting in only 50% of the active ingredient all-trans isomer content in the final product, which affects the product. Biologically active, reducing the quality of lutein

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  • Method for preparing water-soluble lutein
  • Method for preparing water-soluble lutein

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Take 100g of marigold oleoresin with a content of 130g / kg, put it into a saponification tank, add 10g of glycerin, raise the temperature to 80°C, and keep the stirring speed at 150rpm, continuously add 34ml of KOH aqueous solution with a concentration of 10mol / L for 1 hour, and saponify After 4 hours, then add 1000g of deionized water at 80°C, add 110g of hydrochloric acid with a mass concentration of 10%, and make the pH value 5.8, then add 1100g of n-hexane for extraction, extract 3 times, and add 2g of diluent after extraction Sodium isoVC and 8g Tween-80; then 50g of soluble starch was dissolved in 300g of deionized water at 80°C for 30 minutes, then 30g of sucrose was added to dissolve, cooled to 45°C to obtain a diluent for use. The dilution and the wall material solution were mixed twice in a high-shear homogeneous emulsifier, and then the water was removed by spray drying to finally obtain an aqueous solution lutein powder with a content of 105.3g / kg and a weight...

Embodiment 2

[0044] Take 50 g of marigold oleoresin with a content of 145 g / kg, put it into a saponification tank, add 7.5 g of propylene glycol, raise the temperature to 85° C., and keep the stirring speed at 100 rpm, and continuously drop 17 ml of NaOH aqueous solution with a concentration of 10 mol / L for 1 hour. After 4 hours of saponification time, add 300g of deionized water at 85°C, add 102g of sulfuric acid with a mass concentration of 10%, and make the pH value 4.0, then add 1040g of 6# solvent oil for extraction, extract 4 times, and dilute the diluted solution after extraction , add 4.6g of natural VE and 5.7g of Span-80; dissolve 55g of soluble starch in 350g of deionized water at 80°C for 30 minutes, then add 20g of glucose to dissolve, cool to 45°C to obtain a diluted solution for use. The diluent and the wall material solution are mixed twice in a high-shear homogeneous emulsifier, and then the water is removed by spray drying to finally obtain an aqueous solution lutein powde...

Embodiment 3

[0046] Take 150g of marigold oleoresin with a content of 100g / kg, put it into a saponification tank, add 7.5g of mannitol, raise the temperature to 95°C, and keep the stirring speed at 100rpm, and continuously add 51ml of NaOH aqueous solution with a concentration of 10mol / L for 1 hour After 4 hours of saponification time, add 150g of deionized water at 95°C, add 185g of phosphoric acid with a mass concentration of 10%, and make the pH value 6.0, then add 1200g of petroleum ether for extraction, extract 5 times, and add the diluent after extraction to 5.24g of rosemary and 8.74g of sucrose ester; 30g of soluble starch was dissolved in 90g of deionized water at 80°C for 30 minutes, then 18.5g of β-cyclodextrin was added to dissolve, cooled to 45°C to obtain a diluted solution for use. The diluent and the wall material solution are mixed twice in a high-shear homogeneous emulsifier, and then the water is removed by spray drying to finally obtain an aqueous solution lutein powder ...

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Abstract

The invention discloses a method for preparing water-soluble lutein, which includes: throwing marigold oil resin into a saponification tank, adding alcohol compounds into the saponification tank, leading temperature inside the saponification tank to rise to 80-95 DEG C, and continuously dropwise adding strong alkali solutions into the saponification tank to be reacted sufficiently so as to obtain nanoscale lutein crystals; diluting the nanoscale lutein crystals for 1-10 times by aid of deionized water at temperature of 70-90 DEG C, and adjusting potential of hydrogen (pH) of the diluted nanoscale lutein crystals to be 4-7 by aid of acid to obtain diluent; and adding organic solvents into the diluent by weight ratio of 1:1-1:3, and extracting for 2-5 times to obtain the pure lutein. Through the method, the lutein crystals obtained by aid of the marigold oil resin through a special saponification process reach the nanoscale, and lutein quality and lutein production yield are improved.

Description

technical field [0001] The invention relates to a method for preparing water-soluble lutein. Background technique [0002] Lutein belongs to carotenoid, which is a kind of natural pigment. It has bright color, strong tinting power, good anti-oxidation, safe and non-toxic, and has rich nutritional value. It is a natural substance that widely exists in vegetables, flowers, fruits and certain algae plants, and is widely used in many fields such as food, health care products, cosmetics, medicine and animal and poultry feed. The U.S. Food and Drug Administration has approved lutein as a food supplement for use in food as early as 1995. The Chinese Ministry of Health has formulated a national standard for lutein in 2011 and approved it as a food coloring agent for use in food. Because lutein is widely used, 1g of lutein is equivalent to 1g of gold in the international market, so it has the reputation of "plant gold". In the 1980s, Western researchers discovered that lutein, a ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C403/24A23L1/275A61K9/50A61K31/047
Inventor 王东王发合梁全喜王文丽孟祥云
Owner 青岛赛特生物科技有限公司
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