Ionized iron (III) coordination compound containing phenol-bridged imidazolium and application thereof

Abstract

The invention discloses an ionized iron (III) coordination compound containing phenol-bridged imidazolium. The ionized iron (III) coordination compound containing the phenol-bridged imidazolium is characterized by having a chemical general formula as follows: [O-4-C(CH3)3-C6H2-2,6-di-{CH2[CH(NCHCHNR)]}FeX4, wherein R is selected from one of benzyl, 2,6-diisopropyl phenyl, mesityl and saturated alkyl from C1 to C4; and X is chlorine or bromine. Aryloxy-bridged bis(N-heterocyclic carbine) synthesized in situ in the catalysis process of the ionized iron (III) coordination compound containing the phenol-bridged imidazolium disclosed by the invention is not only beneficial to the generation of a low-valence-state iron catalytic active center, but also capable of more effectively stabilizing the low-valence-state iron catalytic active center, so that the ionized iron (III) coordination compound disclosed by the invention has extremely high catalytic activity for the cross-coupling reaction between an aryl grignard reagent and alkyl halohydrocarbon containing b-H and novel efficient catalysts are developed.

Description

technical field [0001] The invention belongs to the field of ligands and complexes, in particular to an ionic iron (III) complex containing phenol bridged imidazolium salt and its application. Background technique [0002] The transition metal-catalyzed cross-coupling reaction between nucleophilic carbon atoms and halogenated hydrocarbons is an important reaction type for the formation of C-C bonds. It has become an indispensable means in organic synthesis and is widely used in biology, medicine, pesticides, fine The synthesis of chemicals and advanced materials, etc., has brought significant economic benefits to society (see: de Meijere, A.; Diederich, F.; Eds. Metal-Catalyzed Cross-Coupling Reactions, 2nd ed.; Wiley-VCH : Weinheim, 2004). In the past 30 years, a large number of transition metal catalysts have been developed, the most effective of which are the palladium and nickel-based catalysts, which not only provide the most abundant and efficient catalytic performanc...

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Problems solved by technology

[0007] So far, in the application of iron-based catalytic systems with imidazolium salts as auxiliary ligands in the cross-coupling reaction between aryl Grignard reagents and β-H-containing alkyl halides, the imidazolium salts used They are all monoimidazole ring systems, and there are no reports of iron-based catalysts containing bis-imidazole ring systems, that is, phenol-bridged bis-imidazole salts.

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