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Rare earth doped gadolinium-potassium fluoride nanometer material for magneto-optical double-module biological marker and preparation method thereof

A technology of rare earth doping and potassium gadolinium fluoride, which is applied in nanotechnology, luminescent materials, chemical instruments and methods for materials and surface science, and can solve the problems of unfavorable magnetic resonance imaging detection, damage to optical and magnetic properties, Detect problems such as unstable signals, achieve the effect of low cost, large magnetic relaxation rate, and narrow emission peak

Active Publication Date: 2015-07-15
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of this hybrid material in the field of biomarkers faces many difficulties, such as the magnetic induction effect of superparamagnetic iron oxide nanoparticles on normal tissue is not conducive to its magnetic resonance imaging detection in vivo; the photobleaching of organic dyes , emission peak width, and light chromaticity impurity lead to the instability of its detection signal; quantum dots are highly toxic and costly to prepare, so they are not suitable for in vivo imaging marker materials
In addition, combining two different particles tends to destroy their respective optical and magnetic properties, and inevitably increases the particle size, resulting in greatly reduced application effects

Method used

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  • Rare earth doped gadolinium-potassium fluoride nanometer material for magneto-optical double-module biological marker and preparation method thereof
  • Rare earth doped gadolinium-potassium fluoride nanometer material for magneto-optical double-module biological marker and preparation method thereof
  • Rare earth doped gadolinium-potassium fluoride nanometer material for magneto-optical double-module biological marker and preparation method thereof

Examples

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Effect test

example 1

[0019] Example 1: Take by weighing 0.0037g europium chloride (EuCl 3 ·6H 2 O), 0.8g potassium chloride (KCl) and 0.37g gadolinium chloride (GdCl 3 ·6H 2 O) Dissolve completely in 12mL distilled water, then add 1mL ethanol, 20mL ethylene glycol, and 10mL polypropyleneimine solution, stir to obtain a transparent solution A; dissolve an appropriate amount of ammonium fluoride in 0.5mL distilled water in another beaker, Then add 2.5mL of ethanol and stir to obtain a transparent solution B; under stirring, add solution A dropwise to solution B, continue stirring for ten minutes, transfer the solution into a hydrothermal tank, and perform hydrothermal treatment at 170°C for 20 hours. After cooling, the supernatant liquid was removed, and the lower precipitate was washed with water and ethanol three times in turn, then dried, and then dried under vacuum at 60°C to obtain KGdF 4 :Eu 3+ nanocrystalline powder. The nanocrystalline powder is dissolved in distilled water to obtain a ...

example 2

[0020] Example 2: Take by weighing 0.0037g terbium chloride (TbCl 3 ·6H 2 O), 1.8g potassium chloride (KCl) and 0.37g gadolinium chloride (GdCl 3 ·6H 2 O) Dissolve completely in 5mL distilled water, then add 25mL ethanol, 5mL ethylene glycol and 5mL polypropyleneimine solution, and stir to obtain a transparent solution A; in another beaker, dissolve an appropriate amount of ammonium fluoride in 1mL distilled water, then add 1mL Ethanol, stirred to obtain a transparent solution B; under stirring, add solution A dropwise to solution B, continue stirring for 10 minutes, transfer the solution into a hydrothermal tank, and hydrothermally treat it at 110°C for 18 hours. After cooling, put The supernatant was removed, and the lower precipitate was washed with water and ethanol three times in turn, dried, and then dried under vacuum at 50°C to obtain KGdF 4 : Tb nanocrystalline powder. 2 mg KGdF 4 :Tb 3+ Dissolve the nanocrystalline powder in 20mL of distilled water to get KGdF ...

example 3

[0021] Example 3: Take by weighing 0.0037g dysprosium chloride (DyCl 3 ·6H 2 O), 1.8g potassium chloride (KCl) and 0.37g gadolinium chloride (GdCl 3 ·6H 2O) Dissolve completely in 2mL distilled water, then add 28mL ethylene glycol and 0.5mL polypropyleneimine solution, stir to obtain a transparent solution A; dissolve an appropriate amount of ammonium fluoride in 5mL distilled water in another beaker, then add 1mL ethanol, Stir to obtain a transparent solution B; under stirring, add solution A dropwise to solution B, continue stirring for ten minutes, transfer the solution into a hydrothermal tank, and perform hydrothermal treatment at 140°C for 24 hours. After cooling, clear the upper layer The liquid was removed, and the lower precipitate was washed with water and ethanol three times in turn, dried, and then dried under vacuum at 65°C to obtain KGdF 4 : Dy 3+ nanocrystalline powder. 15 mg KGdF 4 : Dy nanocrystalline powder dissolved in 20mL of distilled water, can get ...

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Abstract

The invention relates to a rare earth doped gadolinium-potassium fluoride nanometer material for a magneto-optical double-module biological marker and a preparation method thereof. The preparation method comprises the following steps of: mixing gadolinium chloride, potassium chloride and ammonium fluoride in distilled water, ethanol and ethanediol by utilizing propylene imine as a surface active agent; carrying out hydro-thermal treatment at 50-230 DEG C for a period of time; washing, and drying to obtain a DGdF4:Ln nanometer crystal, wherein the commonest of the DGdF4:Ln nanometer crystal are as follows: xLn3+-(1-x)KGdF4 (Ln=Ce, Pr, Nd, Pm, Sm, Eu, Tb, Dy, Ho, Er, Tm, Yb; x=0-60 mol%). The rare earth doped DGdF4 nanometer fluorescence marker material prepared by adopting the method can not only control the size of nanometer granules at about 25 nanometers, but also has better water solubility, can utilize the amino on the surface to be connected with biological molecules; besides, the biological connection is subjected to hypersensitivity detection by realizing needed specific fluorescence emission in such a way that different rare earth ions are doped in the nanometer granules, namely the rare earth doped DGdF4 nanometer fluorescence marker material obtained through the preparation method has potential in being applied in the field of biological markers; and because gadolinium ions are contained in a matrix, the DGdF4 nanometer crystal can be further used as a T1 magnetic resonance imaging contrast agent.

Description

technical field [0001] The invention relates to a magneto-optical dual-mode biomarker material and a preparation method thereof, in particular to the preparation of a rare earth-doped gadolinium potassium fluoride nanometer material and its application in the field of magneto-optic dual-mode biomarkers. Background technique [0002] Multimodal biological detection has attracted more and more attention from the scientific community and society because of its ability to simultaneously realize imaging detection of multiple modes such as light, nuclear, magnetic and ultrasonic, among which magneto-optical dual-mode biomarkers are particularly attractive. Attention. This is because optical detection, which can provide the highest detection sensitivity among detection methods, is easily limited by the depth of detection. Although magnetic resonance imaging can perform three-dimensional detection, its wide application is limited due to low detection sensitivity and resolution. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06C09K11/85B82Y30/00G01N21/64
Inventor 陈学元鞠强涂大涛李仁富朱浩淼
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI