Method for purifying polysaccharide iron complex based on ultrafiltration membrane method

A technology for polysaccharide iron and complexes, which is applied in the field of purification of polysaccharide iron complexes, can solve the problems of complex process, influence on product purity, membrane pollution, etc., and achieves the effects of simple operation process, easy continuous production and reduction of salt concentration.

Active Publication Date: 2013-07-31
JIANGSU JIUWU HITECH
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  • Abstract
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  • Application Information

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Problems solved by technology

[0005] The purification of polysaccharide iron mainly uses the alcohol precipitation process to separate the salt in the polysaccharide iron complex aqueous solution, but this process is complex and has potential safety hazards, and the recovery of alcohol requires a large amount of steam, resulting in high production costs
Chinese patent CN101108194 discloses an electrodialysis device for the desalination of iron dextran complex aqueous solution, but because it is easy to cause the colloidal particles of iron dextran complex to agglomerate, resulting in pipeline blockage and membrane pollution, and the chlorine gas generated during the operation is easy to corrode device, affecting the industrial application of the method
Chinese patent CN101585887 discloses a method for desalti

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  • Method for purifying polysaccharide iron complex based on ultrafiltration membrane method

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Experimental program
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Effect test

Embodiment 1

[0026] use figure 1 The device shown in the figure deals with the crude pumpkin polysaccharide iron complex aqueous solution synthesized by the ferric chloride method. The ultrafiltration membrane module installed on the device is a multi-channel tubular ceramic ultrafiltration membrane module. The material of the membrane support is alumina, and the material of the membrane layer is Zirconia, with an average pore size of 5 nm, operated as cross-flow filtration. First, concentrate the crude pumpkin polysaccharide iron complex aqueous solution (sodium chloride content is about 15.0%wt, iron content is about 50mg / L) in the feed liquid tank 1 at a temperature of 60°C and a pressure of 0.15MPa. When the volume of the retained liquid in the liquid tank 1 is concentrated to 35% of the original volume, continue to add deionized water to the feed liquid tank, and control the water addition rate to be equal to the permeation flux of the ultrafiltration membrane until the sodium chlori...

Embodiment 2

[0029] use figure 1 The device shown in the figure deals with the crude aqueous solution of angelica polysaccharide iron complex synthesized by the ferric chloride method. The ultrafiltration membrane module installed on the device is a roll-type polyethersulfone ultrafiltration membrane module with a molecular weight cut-off of 5KDa, and the operation method is cross-flow filtration. . Firstly, the crude product aqueous solution of angelica polysaccharide iron complex in feed tank 1 (sodium chloride content is about 15.0%wt, iron content is about 50mg / L) is dialyzed at a temperature of 30°C and a pressure of 0.3MPa, and continuously Add deionized water in the feed liquid tank, control the rate of water addition to be equal to the permeation flux of the ultrafiltration membrane, until the concentration of sodium chloride in the ultrafiltration membrane permeate drops to 2.0%wt, then stop adding water, and the interception in the feed liquid tank 1 The liquid volume was conce...

Embodiment 3

[0032] use figure 1 The device shown in the figure deals with crude aqueous solution of Lycium barbarum polysaccharide iron complex synthesized by ferric chloride method. The ultrafiltration membrane module installed on the device is a flat polyamide ultrafiltration membrane module with a molecular weight cut-off of 10KDa, and the operation method is dead-end filtration. First, concentrate the crude Lycium barbarum polysaccharide iron complex aqueous solution (sodium chloride content is about 15.0%wt, iron content is about 50mg / L) in the feed liquid tank 1 at a temperature of 25°C and a pressure of 0.2MPa. When the volume of the retained liquid in the liquid tank 1 is concentrated to 50% of the original volume, continue to add deionized water to the feed liquid tank, and control the water addition rate to be equal to the permeation flux of the ultrafiltration membrane until the sodium chloride in the permeate of the ultrafiltration membrane The concentration was reduced to 1....

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Abstract

The present invention discloses a method for purifying polysaccharide iron complex, in particular to a method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane separation technology. Specific methods include the following steps of filtering the crude aqueous polysaccharide iron complex with ultrafiltration membrane components, whereby the pore diameter of ultrafiltration membrane components is between 2 and 50nm and molecular weight cutoff is between 5K and 150KDa; intercepting the polysaccharide iron complex by the ultrafiltration membrane, continuously discharging the sodium chloride and free iron ions in the crude aqueous solution through the osmotic solution to improve the purity and the concentration of polysaccharide iron complex in the ultrafiltration retentate liquid. The method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane provided by the invention has the following advantages of 1. simple operation process, safety and energy saving, mild condition and easy for continuous production; 2. reducing the salt concentration in the aqueous polysaccharide iron complex, and increasing the concentration of polysaccharide iron with recovery rate of more than 95%.

Description

[0001] technical field [0002] The invention relates to a purification method of a polysaccharide iron complex, in particular to a method for desalting and concentrating an aqueous solution of a polysaccharide iron complex crude product by using an ultrafiltration membrane separation technology. [0003] Background technique [0004] Polysaccharide iron complexes are a new generation of iron supplements. They not only have suitable complexation stability, but are less irritating to the gastrointestinal tract, and when iron is released, the polysaccharide itself has various biological activities and can be absorbed and utilized. The polysaccharide iron complex is composed of sugar base and glycoside iron. The sugar base can be dextran (dextran), chitosan, sucrose, plant polysaccharide, etc. Iron dextran and iron sucrose have been widely used clinically, and plant polysaccharide iron complexes with plant polysaccharides as ligands have become a hot spot for scholars and the ...

Claims

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Application Information

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IPC IPC(8): C08B37/00B01D61/14A61P3/02
CPCY02P20/10
Inventor 顾俊杰熊福军杨文银张桂花彭文博
Owner JIANGSU JIUWU HITECH
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