31 results about "Polysaccharide iron complex" patented technology

The invention discloses a gynostemma pentaphyllum polysaccharide-iron complex. The complex comprises the following components in percentage by weight: 2%-4% of iron and 40%-60% of gynostemma pentaphyllum polysaccharide, and the dissolvability of the complex in per 100mL of water at 25 DEG C is 10g-11g. A preparation method of the gynostemma pentaphyllum polysaccharide-iron complex comprises the steps of: dissolving the gynostemma pentaphyllum polysaccharide and a complexing agent into distilled water, heating in water bath, and dropwise adding a ferric iron compound water solution while stirring, wherein the mass ratio of the gynostemma pentaphyllum polysaccharide to the complexing agent to the ferric iron compound is 3:1:2; and after the reaction, washing with ethanol to obtain the gynostemma pentaphyllum polysaccharide-iron complex. According to the preparation method, the gynostemma pentaphyllum, which is abundant and low in cost, is adopted as a main raw material, the digestion property and stability of the product are better, the water solution is neutral, and the gynostemma pentaphyllum polysaccharide-iron complex can substitute for an existing iron-supplementary agent for supplementing iron for a human body; the preparation technique is simple and easy to popularize; and a new raw material is provided for producing a novel iron-deficiency iron supplementation agent.

The present invention discloses a method for purifying polysaccharide iron complex, in particular to a method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane separation technology. Specific methods include the following steps of filtering the crude aqueous polysaccharide iron complex with ultrafiltration membrane components, whereby the pore diameter of ultrafiltration membrane components is between 2 and 50nm and molecular weight cutoff is between 5K and 150KDa; intercepting the polysaccharide iron complex by the ultrafiltration membrane, continuously discharging the sodium chloride and free iron ions in the crude aqueous solution through the osmotic solution to improve the purity and the concentration of polysaccharide iron complex in the ultrafiltration retentate liquid. The method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane provided by the invention has the following advantages of 1. simple operation process, safety and energy saving, mild condition and easy for continuous production; 2. reducing the salt concentration in the aqueous polysaccharide iron complex, and increasing the concentration of polysaccharide iron with recovery rate of more than 95%.

The invention relates to a method for preparing a yerbadetajo herb polyferose complex and application thereof, which can be used for effectively solving the problems existing in the preparation of the yerbadetajo herb polyferose complex and the preparation of a medicament for treating iron-deficiency anemia, can be effectively applied to food additives and can be used for improving the immunity of an organism. According to the technical scheme, the method comprises the following steps of: adding distilled water into dried yerbadetajo herb powder for warm soaking and filtering to obtain a yerbadetajo herb polysaccharide solution; adding an NaOH ionic solution into the yerbadetajo herb polysaccharide solution for adjusting the pH value, adding trisodium citrate and FeCl3, dropwise adding with stirring, adjusting the pH to 8-10 with the NaOH solution, immediately stopping dropwise adding an FeCl3 solution and an NaOH solution when a red insoluble matter appears in a reaction solution, centrifuging and removing precipitates to obtain a yerbadetajo herb polyferose complex solution; and dialyzing, depositing in alcohol to obtain precipitates, and washing the precipitates to obtain the yerbadetajo herb polyferose complex. The yerbadetajo herb polyferose complex can be taken as a food additive, can be applied to medicinal use, is a medicament for preventing and treating iron-deficiency anemia, and can be used for improving the immunity of an organism.

The invention relates to compositions and methods for the treatment or prophylaxis of iron deficiency, and in particular of iron deficiency anemia, by administering a composition containing an effective amount of a pharmaceutically acceptable ferrous iron salt; and an effective amount of polysaccharide iron complex.

The invention provides a preparation method and application of a low-molecular porphyra haitanensis polyferose compound. The method is characterized in that low-molecular porphyran is used as a raw material and degraded by redox reaction to obtain low-molecular-weight porphyran with the molecular weight being less than 10000Da; and the polyferose compound synthesized by heating the porphyran and ferric chloride together can be dissolved well and exist stably under a physiological pH condition, and also shows a good effect in the iron-deficiency anemia mouse model experiment. The preparation method has the advantages of being simple and convenient in operation, stable in preparation process, low in preparation cost, etc.; and the preparation method also shows wide applicability to raw materials, namely, any polysaccharide with a proper molecular weight range is applicable to the preparation method.

The invention discloses a method for measuring the dissolution rate of polysaccharide iron complex by liquid phase method. The method comprises the following steps: dissolving a test sample in water, with dissolving time t, filtering the dissolving solution, adding dilute sulfuric acid to the filtrate, heating the filtrate until the color of the filtrate is lighter, cooling the filtrate to the room temperature, adding the equal reaction amount or excess amount of ethylenediamine tetraacetic acid disodium salt solution (EDTA) into the filtrate, and after reaction is completed, measuring the reaction solution by the liquid phase method, recording the chromatogram, measuring the concentration or / and the content of the polysaccharide iron in the tested sample according to the peak area, and thus obtaining the dissolution rate of the tested sample at the dissolving time t. The actual application of the method for measuring the dissolution rate of polysaccharide iron complex by liquid phase method shows that the separation effect is good, the measurement is accurate, the sensitivity is high, the specificity is high, the analysis is simple and quick, and the method can be used for quantifying the dissolving solution of the polysaccharide iron and judging the actual dissolving situation, so as to estimate the absorption and therapeutic effect of the single batch or different batches of the medicines.

A method for removing sodium chloride in cassava starch polysaccharide iron complex liquid, the steps are as follows: A, add tapioca starch and water in the reaction kettle, heat and adjust the pH value, add hydrogen peroxide solution to degrade the cassava starch, and obtain heavy Average molecular weight is the oligosaccharide solution of 3K-27KDa, then add ferric chloride solution and alkali and carry out complexation reaction, obtain tapioca starch polysaccharide iron liquid; B, the tapioca starch polysaccharide iron liquid that step A makes is carried out ultrafiltration, A small molecular tapioca starch polysaccharide iron complex with a molecular weight cut-off of 2.5K-200KDa, removing part of the sodium chloride, C, performing nanofiltration on the permeate from step B, and the small molecular tapioca polysaccharide with a molecular weight cut-off of nanofiltration membrane of 200 Da Iron complex, remove sodium chloride, D, combine the intercepted liquid of step B and step C, and spray dry to obtain solid tapioca starch polysaccharide iron complex, and the nanofiltration permeate can be directly discharged. The invention has the advantages of simple process, energy saving and environmental protection, mild conditions and easy continuous production; it can reduce the concentration of sodium chloride in the cassava starch polysaccharide iron complex liquid; the recovery rate of the cassava starch polysaccharide iron complex is greater than 99%, and the removal rate of sodium chloride is greater than 99%. 98%.

The invention discloses a preparation process and a quality detection method of a polysaccharide-iron complex. The specific steps are: add the syrup solution in the reaction tank to stir, and cool; add the ferric chloride solution to stir, add the sodium hydroxide solution to generate a brownish red gel; add the precipitate obtained by adding the sodium hydroxide solution, add a precipitant to wash twice, Dried, that is polysaccharide iron complex. The preparation method of the present invention has few reaction steps, mild reaction conditions, good reproducibility, reliable process conditions, and no need for refrigeration equipment; no waste gas is generated during the reaction, which reduces the possibility of excessive pressure in the reaction tank in industrial production. Explosive hazard. The method for determining the content of the polysaccharide-iron complex has high accuracy, good precision, strong specificity and durability, meets the requirement of linearity, and is accurate, sensitive and simple.

The invention discloses a preparation method and an application of a pyracantha fortuneana polysaccharide-iron complex. The preparation method of the pyracantha fortuneana polysaccharide-iron complexcomprises the steps as follows: adding trisodium citrate to a water solution of pyracantha fortuneana polysaccharide to form a mixed solution under the stirring action, then, adding a ferric chloridesolution and a sodium hydroxide solution until the pH value of the mixed solution is 7-9 to form a reaction solution; heating the reaction solution to 50-70 DEG C to react for 1-2 h, performing cooling, and separating and purifying a reaction product produced in the reaction solution to obtain the pyracantha fortuneana polysaccharide-iron complex. The pyracantha fortuneana polysaccharide is used as glycoside to react with iron chloride to prepare the pyracantha fortuneana polysaccharide-iron complex, and the iron content of the prepared pyracantha fortuneana polysaccharide-iron complex is increased through optimization of the process condition, so that the pyracantha fortuneana polysaccharide-iron complex has higher bioactivity.