31 results about "Polysaccharide iron complex" patented technology

The invention relates to compositions and methods for the treatment or prophylaxis of iron deficiency, and in particular of iron deficiency anemia, by administering a composition containing an effective amount of a pharmaceutically acceptable ferrous iron salt; and an effective amount of polysaccharide iron complex.

The present invention discloses a method for purifying polysaccharide iron complex, in particular to a method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane separation technology. Specific methods include the following steps of filtering the crude aqueous polysaccharide iron complex with ultrafiltration membrane components, whereby the pore diameter of ultrafiltration membrane components is between 2 and 50nm and molecular weight cutoff is between 5K and 150KDa; intercepting the polysaccharide iron complex by the ultrafiltration membrane, continuously discharging the sodium chloride and free iron ions in the crude aqueous solution through the osmotic solution to improve the purity and the concentration of polysaccharide iron complex in the ultrafiltration retentate liquid. The method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane provided by the invention has the following advantages of 1. simple operation process, safety and energy saving, mild condition and easy for continuous production; 2. reducing the salt concentration in the aqueous polysaccharide iron complex, and increasing the concentration of polysaccharide iron with recovery rate of more than 95%.

The invention discloses a preparation method and mass detection method of a polysaccharide-iron complex. The preparation method comprises the following steps: adding an aqueous solution of ferric trichloride and syrup into a reaction tank and stirring; dissolving with an alkaline solution, and stirring for realizing stable complexing with iron ions to generate a polysaccharide-iron complex; and centrifuging, washing and drying. The preparation method has the advantages of few reaction steps, mild reaction conditions, good reproducibility, reliable process conditions and operability; and no harmful gas is generated in the reaction. The method for measuring the content of polysaccharide-iron complex provided by the invention has high accuracy, good precision and strong specificity and durability, meets the linear requirements and is accurate, sensitive and simple and convenient.

The invention relates to a method for preparing a yerbadetajo herb polyferose complex and application thereof, which can be used for effectively solving the problems existing in the preparation of the yerbadetajo herb polyferose complex and the preparation of a medicament for treating iron-deficiency anemia, can be effectively applied to food additives and can be used for improving the immunity of an organism. According to the technical scheme, the method comprises the following steps of: adding distilled water into dried yerbadetajo herb powder for warm soaking and filtering to obtain a yerbadetajo herb polysaccharide solution; adding an NaOH ionic solution into the yerbadetajo herb polysaccharide solution for adjusting the pH value, adding trisodium citrate and FeCl3, dropwise adding with stirring, adjusting the pH to 8-10 with the NaOH solution, immediately stopping dropwise adding an FeCl3 solution and an NaOH solution when a red insoluble matter appears in a reaction solution, centrifuging and removing precipitates to obtain a yerbadetajo herb polyferose complex solution; and dialyzing, depositing in alcohol to obtain precipitates, and washing the precipitates to obtain the yerbadetajo herb polyferose complex. The yerbadetajo herb polyferose complex can be taken as a food additive, can be applied to medicinal use, is a medicament for preventing and treating iron-deficiency anemia, and can be used for improving the immunity of an organism.

The invention discloses a preparation process and a quality detection method of a polysaccharide-iron complex. The specific steps comprise: adding a syrup solution into a reaction tank, stirring, and cooling; adding a ferric chloride solution, stirring, and adding a sodium hydroxide solution to generate a red-brown gel; and adding a sodium hydroxide solution to obtain a precipitate, adding a precipitating agent to wash the precipitate twice, and drying to obtain the polysaccharide-iron complex. According to the present invention, the reaction steps are less, the reaction conditions are mild, reproducibility is good, the process conditions are reliable, and refrigeration equipment is not required; no waste gas is generated during the reaction, such that the problems that the pressure in the reaction tank is too high and the explosive hazard can be generated in the industrial production are reduced; and the polysaccharide-iron complex content determination method has characteristics of high accuracy, good precision, strong specificity, strong durability, meeting of linearity requirements, good accurate, high sensitivity, and simpleness.

The invention discloses a gynostemma pentaphyllum polysaccharide-iron complex. The complex comprises the following components in percentage by weight: 2%-4% of iron and 40%-60% of gynostemma pentaphyllum polysaccharide, and the dissolvability of the complex in per 100mL of water at 25 DEG C is 10g-11g. A preparation method of the gynostemma pentaphyllum polysaccharide-iron complex comprises the steps of: dissolving the gynostemma pentaphyllum polysaccharide and a complexing agent into distilled water, heating in water bath, and dropwise adding a ferric iron compound water solution while stirring, wherein the mass ratio of the gynostemma pentaphyllum polysaccharide to the complexing agent to the ferric iron compound is 3:1:2; and after the reaction, washing with ethanol to obtain the gynostemma pentaphyllum polysaccharide-iron complex. According to the preparation method, the gynostemma pentaphyllum, which is abundant and low in cost, is adopted as a main raw material, the digestion property and stability of the product are better, the water solution is neutral, and the gynostemma pentaphyllum polysaccharide-iron complex can substitute for an existing iron-supplementary agent for supplementing iron for a human body; the preparation technique is simple and easy to popularize; and a new raw material is provided for producing a novel iron-deficiency iron supplementation agent.

The invention discloses a gynostemma pentaphyllum polysaccharide-iron complex. The complex comprises the following components in percentage by weight: 2%-4% of iron and 40%-60% of gynostemma pentaphyllum polysaccharide, and the dissolvability of the complex in per 100mL of water at 25 DEG C is 10g-11g. A preparation method of the gynostemma pentaphyllum polysaccharide-iron complex comprises the steps of: dissolving the gynostemma pentaphyllum polysaccharide and a complexing agent into distilled water, heating in water bath, and dropwise adding a ferric iron compound water solution while stirring, wherein the mass ratio of the gynostemma pentaphyllum polysaccharide to the complexing agent to the ferric iron compound is 3:1:2; and after the reaction, washing with ethanol to obtain the gynostemma pentaphyllum polysaccharide-iron complex. According to the preparation method, the gynostemma pentaphyllum, which is abundant and low in cost, is adopted as a main raw material, the digestion property and stability of the product are better, the water solution is neutral, and the gynostemma pentaphyllum polysaccharide-iron complex can substitute for an existing iron-supplementary agent for supplementing iron for a human body; the preparation technique is simple and easy to popularize; and a new raw material is provided for producing a novel iron-deficiency iron supplementation agent.

The present invention discloses a method for purifying polysaccharide iron complex, in particular to a method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane separation technology. Specific methods include the following steps of filtering the crude aqueous polysaccharide iron complex with ultrafiltration membrane components, whereby the pore diameter of ultrafiltration membrane components is between 2 and 50nm and molecular weight cutoff is between 5K and 150KDa; intercepting the polysaccharide iron complex by the ultrafiltration membrane, continuously discharging the sodium chloride and free iron ions in the crude aqueous solution through the osmotic solution to improve the purity and the concentration of polysaccharide iron complex in the ultrafiltration retentate liquid. The method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane provided by the invention has the following advantages of 1. simple operation process, safety and energy saving, mild condition and easy for continuous production; 2. reducing the salt concentration in the aqueous polysaccharide iron complex, and increasing the concentration of polysaccharide iron with recovery rate of more than 95%.

The invention relates to a preparing method of a cassava polysaccharide-iron complex. The method includes subjecting cassava starch to oxidative degradation by utilizing hydrogen peroxide to obtain anapplicable oligosaccharide solution; then adding dropwise an iron trichloride solution and a sodium hydroxide solution into the oligosaccharide solution to perform a complexing reaction to obtain a cassava polysaccharide-iron complex synthesis solution; performing filtration to remove water-insoluble impurities to obtain a cassava polysaccharide-iron complex solution; desalting and concentratingthe solution by adopting an ultrafiltration membrane process; and subjecting a product to spray-drying or vacuum evaporation drying, and crushing to obtain a cassava polysaccharide-iron complex product. The hydrogen peroxide is adopted to perform oxidative degradation on the cassava starch so as to replace previous acid-method or enzyme-method degradation processes, and therefore generation of a side product that is glucose in the method is significantly reduced than that in acid methods, a higher yield of applicable oligosaccharide is obtained, and the degradation time is greatly shortened than that of enzyme methods, thus reducing the production cost. Sodium chloride removal utilizing an ethanol or methanol solvent is replaced, thus avoiding use of flammable and combustible substances such as ethanol or methanol and eliminating hidden safety risks. The prepared cassava polysaccharide-iron complex can be used as an iron supplementing agent for livestock and poultry.

The invention discloses a preparation method and an application of a pyracantha fortuneana polysaccharide-iron complex. The preparation method of the pyracantha fortuneana polysaccharide-iron complexcomprises the steps as follows: adding trisodium citrate to a water solution of pyracantha fortuneana polysaccharide to form a mixed solution under the stirring action, then, adding a ferric chloridesolution and a sodium hydroxide solution until the pH value of the mixed solution is 7-9 to form a reaction solution; heating the reaction solution to 50-70 DEG C to react for 1-2 h, performing cooling, and separating and purifying a reaction product produced in the reaction solution to obtain the pyracantha fortuneana polysaccharide-iron complex. The pyracantha fortuneana polysaccharide is used as glycoside to react with iron chloride to prepare the pyracantha fortuneana polysaccharide-iron complex, and the iron content of the prepared pyracantha fortuneana polysaccharide-iron complex is increased through optimization of the process condition, so that the pyracantha fortuneana polysaccharide-iron complex has higher bioactivity.

The invention relates to a polysaccharide iron complex separating and purifying method. The method can effectively purify a polysaccharide iron complex, effectively remove impurities of chloride and heavy metals in the polysaccharide iron complex to improve the purity and drug use safety of the polysaccharide iron complex; and the method is low in cost, simple in process and easy in industrialization production.

The invention relates to a method for preparing a yerbadetajo herb polyferose complex and application thereof, which can be used for effectively solving the problems existing in the preparation of the yerbadetajo herb polyferose complex and the preparation of a medicament for treating iron-deficiency anemia, can be effectively applied to food additives and can be used for improving the immunity of an organism. According to the technical scheme, the method comprises the following steps of: adding distilled water into dried yerbadetajo herb powder for warm soaking and filtering to obtain a yerbadetajo herb polysaccharide solution; adding an NaOH ionic solution into the yerbadetajo herb polysaccharide solution for adjusting the pH value, adding trisodium citrate and FeCl3, dropwise adding with stirring, adjusting the pH to 8-10 with the NaOH solution, immediately stopping dropwise adding an FeCl3 solution and an NaOH solution when a red insoluble matter appears in a reaction solution, centrifuging and removing precipitates to obtain a yerbadetajo herb polyferose complex solution; and dialyzing, depositing in alcohol to obtain precipitates, and washing the precipitates to obtain the yerbadetajo herb polyferose complex. The yerbadetajo herb polyferose complex can be taken as a food additive, can be applied to medicinal use, is a medicament for preventing and treating iron-deficiency anemia, and can be used for improving the immunity of an organism.

The invention relates to a method for removing sodium chloride from cassava starch polysaccharide-iron complex liquid. The method comprises the following steps: A, adding cassava starch and water intoa reaction kettle, heating and regulating pH value, adding hydrogen peroxide solution to degrade the cassava starch, so as to obtain oligosaccharide solution with the weight-average molecular weightof 3-27KDa, then adding ferric trichloride solution and alkali, and carrying out complex reaction, so that cassava starch polysaccharide iron liquid is obtained; B, carrying out ultrafiltration on thecassava starch polysaccharide iron liquid obtained in the step A, and intercepting micromolecular cassava starch polysaccharide iron complex with the molecular weight of 2.5-200KDa to remove part ofsodium chloride; C, carrying out nanofiltration on permeate liquid obtained in the step B, and intercepting micromolecular cassava starch polysaccharide iron complex with the molecular weight of 200 Da by virtue of a nanofiltration membrane to remove sodium chloride; and D, mixing interception liquids obtained in the steps B and C, and carrying out spray drying, so that solid cassava starch polysaccharide iron complex is obtained, and nanofiltration permeate liquid can be directly discharged. The method provided by the invention has the advantages that technology is simple, energy conservationand environmental protection are realized, conditions are mild, and continuous production can be easily realized; concentration of sodium chloride in the cassava starch polysaccharide-iron complex liquid can be lowered; and recovery rate of the cassava starch polysaccharide iron complex is higher than 99%; and removal rate of sodium chloride is higher than 98%.

The invention discloses a preparation method and applications of a Codonopsis pilosula polysaccharide-iron complex, and relates to the technical field of macromolecule polysaccharides. The preparationmethod comprises: adding citric acid to a Codonopsis pilosula polysaccharide aqueous solution, and stirring uniformly to form a mixed solution; adding a ferric chloride solution and a sodium hydroxide solution to the mixed solution in a dropwise manner under a stirring condition, and carrying out a reaction to obtain a mixture; and carrying out separation purification treatment on the mixture toobtain the Codonopsis pilosula polysaccharide-iron complex. According to the present invention, the prepared Codonopsis pilosula polysaccharide-iron complex is easily absorbed and utilized by the body, has high bioavailability, cannot cause adverse effects on the gastrointestinal tract, can supplement the body with safe and non-toxic iron elements, and has good antitumor activity.

The invention discloses a preparation method and applications of fluorescently-labeled rice bran polysaccharide iron complex, and belongs to the technical field of tracing technology. The preparationmethod comprises following steps: rice bran polysaccharide iron complex and rhodamine B are dissolved in water, an aprotic solvent is added so as to obtain a mixed solution; the mixed solution is subjected to dialysis so as to obtain a reservation liquid; absolute ethanol is added into the reservation liquid so as to obtain a precipitate; the precipitate is washed and dried so as to obtain the fluorescently-labeled rice bran polysaccharide iron complex. According to the preparation method, reaction of the reductive end terminals in rice bran polysaccharide iron complex molecules with the active amino groups in rhodamine B can be realized, the rice bran polysaccharide iron complex-rhodamine B compound, that is to say the fluorescently-labeled rice bran polysaccharide iron complex is prepared, the preparation method is simple, and maneuverability is high. The fluorescently-labeled rice bran polysaccharide iron complex is applied in tracing of rice bran polysaccharide iron complex, so that a rapid convenient method is provided for tracing of rice bran polysaccharide iron complex is provided, and a problem in the prior art that tracing of rice bran polysaccharide iron complex is difficult is solved.

The invention relates to a polysaccharide carrier with an endocytosis mediation function, and a preparation method thereof. A finally prepared Inonotus obliquus polysaccharide iron complex carrier canload Inonotus obliquus polysaccharides well and is capable of binding to an internalization receptor on the surface of a cell at the same time to trigger the activation of the endocytosis function ofthe cell so as to realize transmembrane transport of the polysaccharides, and thus, the Inonotus obliquus polysaccharides can enter the cell well to achieve its function in treating and preventing diseases.

The invention provides a preparation method and application of a low-molecular porphyra haitanensis polyferose compound. The method is characterized in that low-molecular porphyran is used as a raw material and degraded by redox reaction to obtain low-molecular-weight porphyran with the molecular weight being less than 10000Da; and the polyferose compound synthesized by heating the porphyran and ferric chloride together can be dissolved well and exist stably under a physiological pH condition, and also shows a good effect in the iron-deficiency anemia mouse model experiment. The preparation method has the advantages of being simple and convenient in operation, stable in preparation process, low in preparation cost, etc.; and the preparation method also shows wide applicability to raw materials, namely, any polysaccharide with a proper molecular weight range is applicable to the preparation method.

The invention discloses a traditional Chinese medicine and western medicine combined preparation for treating antepartum eclampsia and a preparation method, and belongs to the technical field of medicines. Active ingredients of the traditional Chinese medicine and western medicine combined preparation provided by the invention comprise the following raw materials: vitamin B1, bepridil, polysaccharide-iron complex, radix rhododendri simsii, pedes suillus, rubus alexeterius, folium rumicis, retinervus luffae fructus, herba scutellariae orthocalycis, calculus macacae mulattae, herba renantherae coccineae, circaea alpina, herba lysimachia hypericoides hemsl, rhizoma et radix oryzae glutinosae, caulis vitis quinquangularis, herba equiseti hiemalis and pilea pumila. The traditional Chinese medicine and western medicine combined preparation is prepared by combining traditional Chinese medicines with western medicines, has significant efficacy for treatment of antepartum eclampsia-induced meridian spasm, throbbing pain of limbs, wander in mind and other symptoms, is short in treatment course, fast to take effect, high in cure rate, safe and reliable, free of toxic and side effects, convenient to take and low in cost, and also has the effects of clearing liver to stop wind, stopping bleeding and preventing miscarriage, tranquilizing the mind and relieving spasm.

The invention discloses a method for measuring the dissolution rate of polysaccharide iron complex by liquid phase method. The method comprises the following steps: dissolving a test sample in water, with dissolving time t, filtering the dissolving solution, adding dilute sulfuric acid to the filtrate, heating the filtrate until the color of the filtrate is lighter, cooling the filtrate to the room temperature, adding the equal reaction amount or excess amount of ethylenediamine tetraacetic acid disodium salt solution (EDTA) into the filtrate, and after reaction is completed, measuring the reaction solution by the liquid phase method, recording the chromatogram, measuring the concentration or / and the content of the polysaccharide iron in the tested sample according to the peak area, and thus obtaining the dissolution rate of the tested sample at the dissolving time t. The actual application of the method for measuring the dissolution rate of polysaccharide iron complex by liquid phase method shows that the separation effect is good, the measurement is accurate, the sensitivity is high, the specificity is high, the analysis is simple and quick, and the method can be used for quantifying the dissolving solution of the polysaccharide iron and judging the actual dissolving situation, so as to estimate the absorption and therapeutic effect of the single batch or different batches of the medicines.

The invention discloses an integrated traditional Chinese and western medicine medicine for treating proliferative anemia and a preparation method thereof, belonging to the technical field of medicine; the raw materials of the active ingredients of the medicine integrated traditional Chinese and western medicine are composed of polysaccharide iron complex, ferrous sulfate, and adenosylcobalamin , red door orchid, Huaguai vine root, ground silkworm, cow horse vine, velvety bayberry, three tiles, shiitake mushroom, Caragana root, mulberry fruit, thorn pear, rock cabbage and pomelo parasitism; the medicine of integrated traditional Chinese and western medicine of the present invention has The effects of nourishing qi and blood, nourishing liver and kidney, cooling blood to stop bleeding, nourishing yin and invigorating spleen have significant effects on the treatment of iron deficiency anemia, hemolytic anemia, acute hemorrhagic anemia, and anemia caused by rheumatic fever, endocrine disorders, and vitamin deficiency. Curative effect, and the course of treatment is short, quick effect, convenient to take, good absorption effect, low cost, simple preparation process.

The invention discloses a method for measuring the dissolution rate of polysaccharide iron complex by liquid phase method. The method comprises the following steps: dissolving a test sample in water, with dissolving time t, filtering the dissolving solution, adding dilute sulfuric acid to the filtrate, heating the filtrate until the color of the filtrate is lighter, cooling the filtrate to the room temperature, adding the equal reaction amount or excess amount of ethylenediamine tetraacetic acid disodium salt solution (EDTA) into the filtrate, and after reaction is completed, measuring the reaction solution by the liquid phase method, recording the chromatogram, measuring the concentration or / and the content of the polysaccharide iron in the tested sample according to the peak area, and thus obtaining the dissolution rate of the tested sample at the dissolving time t. The actual application of the method for measuring the dissolution rate of polysaccharide iron complex by liquid phase method shows that the separation effect is good, the measurement is accurate, the sensitivity is high, the specificity is high, the analysis is simple and quick, and the method can be used for quantifying the dissolving solution of the polysaccharide iron and judging the actual dissolving situation, so as to estimate the absorption and therapeutic effect of the single batch or different batches of the medicines.

The invention discloses a preparation method and application of Codonopsis polysaccharide-iron complex, and relates to the technical field of polymer polysaccharides. The preparation method of the Codonopsis polysaccharide-iron complex comprises the following steps: adding citric acid into the aqueous solution of Codonopsis polysaccharide, stirring evenly to form a mixed solution; under stirring condition, adding ferric chloride solution dropwise into the mixed solution react with sodium hydroxide solution to obtain a mixture; separate and purify the mixture to obtain Codonopsis polysaccharide-iron complex. The Codonopsis polysaccharide-iron complex prepared by the invention is easy to be absorbed and utilized by the body, has high bioavailability, does not have adverse effects on the gastrointestinal tract, can supplement safe and non-toxic iron elements for the body, and has better anti-tumor effect active.

An iron supplement nutritional formulation for infants and adults is provided using a non-nutritive sweetener including an extract from monk fruit (Siraitia grosvenorii) in combination with a polysaccharide iron complex. The formulation improves the taste and palatability of the supplement, thereby increasing the dosage accuracy within children and infants who tend to spit out or regurgitate other forms of polysaccharide iron complexes.

The invention discloses a compound tablet for treating functional uterine bleeding and a preparation method thereof. The compound table comprises the following main ingredients: etamsylate, hoof nail polypeptide, lecithin, soyabean protein, estradiol benzoate, aminomethyl benzoic acid, norethindrone and ferrous fumarate, and further comprises polysaccharide-iron complex, pavlova viridis se-polysaccharide, seabuckthorn flavone, galactooligosaccharide, progesterone and iron-protein succinylate. By combining with various medical ingredients, the compound tablet has the functions of astringing proctoptosia, nourishing yin and supplementing blood, tonifying liver and kidney, performing antisepsis and anti-inflammation, removing blood stasis and stopping bleeding, and invigorating spleen and supplementing qi; besides, the compound tablet can improve the blood circulation, shortens the wound healing time, nurses the health of patients while stopping the bleeding, and enhances the immunity of the patients; furthermore, the compound tablet is convenient to take, definite in curative effect and low in costs, can relieve the surgery pain of the patients and reduce the economical burden of the patients, and has a wide application prospect.

A method for removing sodium chloride in cassava starch polysaccharide iron complex liquid, the steps are as follows: A, add tapioca starch and water in the reaction kettle, heat and adjust the pH value, add hydrogen peroxide solution to degrade the cassava starch, and obtain heavy Average molecular weight is the oligosaccharide solution of 3K-27KDa, then add ferric chloride solution and alkali and carry out complexation reaction, obtain tapioca starch polysaccharide iron liquid; B, the tapioca starch polysaccharide iron liquid that step A makes is carried out ultrafiltration, A small molecular tapioca starch polysaccharide iron complex with a molecular weight cut-off of 2.5K-200KDa, removing part of the sodium chloride, C, performing nanofiltration on the permeate from step B, and the small molecular tapioca polysaccharide with a molecular weight cut-off of nanofiltration membrane of 200 Da Iron complex, remove sodium chloride, D, combine the intercepted liquid of step B and step C, and spray dry to obtain solid tapioca starch polysaccharide iron complex, and the nanofiltration permeate can be directly discharged. The invention has the advantages of simple process, energy saving and environmental protection, mild conditions and easy continuous production; it can reduce the concentration of sodium chloride in the cassava starch polysaccharide iron complex liquid; the recovery rate of the cassava starch polysaccharide iron complex is greater than 99%, and the removal rate of sodium chloride is greater than 99%. 98%.

The invention discloses a preparation process and a quality detection method of a polysaccharide-iron complex. The specific steps are: add the syrup solution in the reaction tank to stir, and cool; add the ferric chloride solution to stir, add the sodium hydroxide solution to generate a brownish red gel; add the precipitate obtained by adding the sodium hydroxide solution, add a precipitant to wash twice, Dried, that is polysaccharide iron complex. The preparation method of the present invention has few reaction steps, mild reaction conditions, good reproducibility, reliable process conditions, and no need for refrigeration equipment; no waste gas is generated during the reaction, which reduces the possibility of excessive pressure in the reaction tank in industrial production. Explosive hazard. The method for determining the content of the polysaccharide-iron complex has high accuracy, good precision, strong specificity and durability, meets the requirement of linearity, and is accurate, sensitive and simple.

The invention discloses a preparation method of a polysaccharide-iron complex and a quality detection method thereof. The preparation method is as follows: adding ferric chloride aqueous solution and syrup into a reaction tank and stirring, dissolving with alkali solution, stirring and stabilizing complexing with iron ions to form polysaccharide iron complexes, centrifuging, washing and drying. The preparation method has few reaction steps, mild reaction conditions, good reproducibility, reliable process conditions and operability; and no harmful gas is generated in the reaction. The method for determining the content of the polysaccharide-iron complex has high accuracy, good precision, strong specificity and durability, meets the requirement of linearity, and is accurate, sensitive and simple.

An iron supplement nutritional formulation for infants and adults is provided using a non-nutritive sweetener including an extract from monk fruit (Siraitia grosvenorii) in combination with a polysaccharide iron complex. The formulation improves the taste and palatability of the supplement, thereby increasing the dosage accuracy within children and infants who tend to spit out or regurgitate other forms of polysaccharide iron complexes.

The invention discloses a preparation method and an application of a pyracantha fortuneana polysaccharide-iron complex. The preparation method of the pyracantha fortuneana polysaccharide-iron complexcomprises the steps as follows: adding trisodium citrate to a water solution of pyracantha fortuneana polysaccharide to form a mixed solution under the stirring action, then, adding a ferric chloridesolution and a sodium hydroxide solution until the pH value of the mixed solution is 7-9 to form a reaction solution; heating the reaction solution to 50-70 DEG C to react for 1-2 h, performing cooling, and separating and purifying a reaction product produced in the reaction solution to obtain the pyracantha fortuneana polysaccharide-iron complex. The pyracantha fortuneana polysaccharide is used as glycoside to react with iron chloride to prepare the pyracantha fortuneana polysaccharide-iron complex, and the iron content of the prepared pyracantha fortuneana polysaccharide-iron complex is increased through optimization of the process condition, so that the pyracantha fortuneana polysaccharide-iron complex has higher bioactivity.