Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of controlled release carrier material of sucrose ester

A technology of controlled release carrier and sucrose ester, applied in pharmaceutical formulations, drug delivery and other directions, can solve the problems of poor biocompatibility, unhelpful human health, and unsuitable for promotion, so as to improve drug efficacy, relieve pain, and improve clinical outcomes. Effects of medication levels

Active Publication Date: 2015-06-10
GUANGXI UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 1. Most of the chemical products such as cross-linking agent and etherification agent used in chemical modification (such as: azo compound, polyethylene glycol, graft copolymerized N-isopropylacrylamide) have certain toxicity and are biocompatible Poor sex, not beneficial to human health, some can only be used in chemical industry, environmental protection and other fields
[0009] 2. The safety of chemically modified glucomannan as a drug carrier needs further evaluation
[0010] 3. Use some toxic chemicals to remove after modifying glucomannan. The process is complicated and there will be certain residues, which pose a threat to human health.
[0011] 4. The polysaccharides physically blended with glucomannan are generally chitosan, carrageenan, xanthan gum, etc., which have a good synergistic effect, but the price is relatively high, which makes the production cost of the drug high and is not suitable for promotion

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of sucrose ester controlled release carrier material:

[0035] 1. Preparation of oxidized glucomannan:

[0036] Use water as the solvent, adjust the pH to 11.0, add hydrogen peroxide at a concentration of 5.0%, add 15g of glucomannan under stirring, fully disperse and evenly heat it at 60°C, and react for 5 hours, reduce the excess with sodium sulfite Hydrogen peroxide terminates the reaction. Cool, precipitate oxidized glucomannan with absolute ethanol, wash with ethanol with a volume concentration of 75%, dehydrate with absolute ethanol, dry and pulverize in vacuum at 70°C;

[0037] 2. Dry heat modification of oxidized glucomannan / starch blend:

[0038] Take 1 g of starch and slowly add it to deionized water, stir continuously, add 9 g of oxidized glucomannan after mixing evenly, adjust the pH to 11.0, and stir at room temperature for 2 h. Dry at 60°C until the moisture content is less than 10%, grind, pulverize and sieve, put the blend in an oven at 17...

Embodiment 2

[0042] Preparation of sucrose ester controlled release carrier material:

[0043] 1. Preparation of oxidized glucomannan:

[0044] Use water as the solvent, adjust the pH to 11.0, add hydrogen peroxide at a concentration of 4.5%, add 20g of glucomannan under stirring, fully disperse and evenly heat it at 50°C, and react for 5 hours, reduce the excess with sodium sulfite Hydrogen peroxide terminates the reaction. Cool, precipitate oxidized glucomannan with absolute ethanol, wash with ethanol at a volume concentration of 75%, dehydrate with absolute ethanol, dry and pulverize in vacuum at 50°C;

[0045] 2. Dry heat modification of oxidized glucomannan / starch blend:

[0046] Take 4 g of starch and slowly add it to deionized water, stir continuously, add 10 g of oxidized glucomannan after mixing evenly, adjust the pH to 11.0, and stir at room temperature for 1 h. Dry at 50°C until the moisture content is less than 10%, grind, pulverize and sieve, put the blend in an oven at 170...

Embodiment 3

[0050] Preparation of sucrose ester controlled release carrier material:

[0051] 1. Preparation of oxidized glucomannan:

[0052] Use water as the solvent, adjust the pH to 7.0, add hydrogen peroxide at a concentration of 3.5%, add 12g of glucomannan under stirring, fully disperse and evenly heat it at 40°C, and react for 3 hours, reduce the excess with sodium sulfite Hydrogen peroxide terminates the reaction. Cool, precipitate oxidized glucomannan with absolute ethanol, wash with 75% ethanol at 7 volume concentration, dehydrate with absolute ethanol, dry in vacuum at 40°C, and pulverize;

[0053] 2. Dry heat modification of oxidized glucomannan / starch blend:

[0054] Take 10 g of starch and slowly add it to deionized water, stir continuously, add 10 g of oxidized glucomannan after mixing evenly, adjust the pH to 7.0, and stir at room temperature for 0.5 h. Drying at 30°C until the moisture content is less than 10%, grinding, pulverizing, and sieving, placing the blend in ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method and application of a controlled release carrier material of sucrose ester. According to the preparation method, a surfactant sucrose ester is added into a prescription of oxidized glucomannan or starch matrix tablet, a water-soluble drug or a water-insoluble drug is taken as a model drug so as to prepare the controlled release carrier material. The preparation method has the characteristics of being environment-friendly and convenient and simple to operate, and having simple steps; the property of dry heat blended products is improved through a dry heat blending technology; sucrose ester is added into the oxidized glucomannan or starch controlled release framework material, so that the compressibility of the material is improved, the drug is delayed to release, the application field of the sucrose ester is enlarged, and the sucrose ester is used for colon-targeted control release of functional active pharmaceutical ingredients.

Description

field of invention [0001] The invention belongs to the field of polymer polysaccharide materials in the controlled release of functional substances, and relates to a preparation method of a sucrose ester controlled release carrier material, and also relates to the controlled release application of the sucrose ester controlled release carrier material. Background technique [0002] The drug controlled release system uses certain materials as the carrier, so that the drug can be slowly released in the body at a certain speed within the required time range according to the designed dose, so as to achieve the purpose of more effective treatment of diseases. The advantages of administering drugs with a drug sustained-release system are: ① avoiding the influence of the drug concentration in plasma with the time of drug intake and the patient's ability to absorb, absorb and eliminate drugs, and can be released at a constant rate, or by responding to environmental changes (magnetic f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/26A61K47/36A61K9/22
Inventor 李坚斌杭方学陆登俊李敏魏承厚张帆廖文敏梁朝昱
Owner GUANGXI UNIV
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com