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Method for producing aseptic bulk drug tylosin salt by utilizing tylosin fermentation broth

A technology of tylosin and fermentation broth, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problems of easy emulsification, low extraction yield, easy environmental pollution, etc., and reduce equipment maintenance. cost, simplify the extraction process, and improve the effect of extraction efficiency

Active Publication Date: 2014-03-19
宁夏泰瑞制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]1) Organic solvents (including ethyl acetate and butyl acetate) are used in the production process, resulting in organic solvents in the generated wastewater, which is easy to pollute the environment
[0006]2) The process cycle of extraction and stripping is long
[0007]3) Low extraction yield
[0008]4) Emulsification is prone to occur during the extraction process
[0009]5) Higher production costs
[0011]1) A large amount of salt is used in the production process, and the used salt cannot be recycled and reused, and it is easy to pollute the environment
[0012]2) Salting out yield is low
[0014]1) Flat membrane ultrafiltration equipment is easy to wear, has poor corrosion resistance, short service life, complicated maintenance and high maintenance cost
[0015]2) Roll-type nanofiltration membrane is not suitable for desalination softening and high-viscosity filtrate treatment
[0016]3) The use of cellulose as the roll-type ultrafiltration membrane has a short service life, is not resistant to high temperature, and is easily damaged by acid and alkali
[0017] In addition, the tylosin salt obtained by the above three processes is a non-sterile raw material drug and cannot be directly used as an injection raw material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Turn on the fermenter to stir, and the speed is controlled at 10r / min. will be 10m 3 Tylosin fermentation broth (chemical potency 13241μ / ml) was heated up to 50°C, 10kg of industrial oxalic acid was added, and the pH was adjusted to 3.2 with 20% hydrochloric acid, and the stirring was continued for 20 minutes. The fermentation broth is transported to a stainless steel metal mesh with a filtration accuracy of 400 μm by a high-pressure centrifugal pump for filtration, and the tylosin residue is washed with drinking water with a pH of 5-6 (adjusted with 20% hydrochloric acid or sulfuric acid) to obtain Tylosin Su filtrate 8.2m 3 , The chemical titer is 16955μ / ml. The pretreatment yield was 105%.

[0049] The tylosin filtrate was filtered through a tubular porous ceramic membrane. Before the filtrate is filtered, the viscosity of the filtrate is adjusted to 3892 cps with purified water. During the membrane filtration process, the pressure is controlled at 1-1.2 bar, an...

Embodiment 2

[0055] Turn on the fermenter to stir, and the rotating speed is controlled at 20r / min. will be 10m 3 Tylosin fermentation broth (chemical potency 13152μ / ml) was heated to 55°C, 25kg of sodium oxalate was added, and the pH was adjusted to 4.1 with 20% sulfuric acid, and stirring was continued for 25 minutes. The fermentation liquid is transported to a stainless steel metal mesh with a filtration accuracy of 450 μm by a high-pressure centrifugal pump for filtration, and the tylosin residue is washed twice with drinking water with a pH of 5-6 (adjusted with 20% hydrochloric acid or sulfuric acid) to obtain Tylosin Loxacin filtrate 8.4m 3 , The chemical titer is 16503μ / ml. The yield of pretreatment was 105.4%.

[0056] The tylosin filtrate was filtered through a tubular porous ceramic membrane. Before the filtrate is filtered, the viscosity of the filtrate is adjusted to 3725cps with purified water, and then passed through a nanofiltration membrane. During the membran...

Embodiment 3

[0062] Turn on the fermenter to stir, and the rotating speed is controlled at 30r / min. will be 10m 3 Tylosin fermentation broth (chemical potency 130874μ / ml) was heated up to 60°C, 50kg of glutamic acid was added, and the pH was adjusted to 4.9 with 20% hydrochloric acid, and the stirring was continued for 30 minutes. The fermentation broth is transported to a stainless steel metal mesh with a filtration accuracy of 500 μm by a high-pressure centrifugal pump for filtration, and the tylosin residue is washed twice with drinking water with a pH of 5-6 (adjusted with 20% hydrochloric acid or sulfuric acid) to obtain Tylosin Rhizoctin filtrate 8.1m 3 , The chemical titer is 14069μ / ml. The yield of pretreatment is 104.8%.

[0063] The tylosin filtrate was filtered through a tubular porous ceramic membrane. Before the filtrate is filtered, the viscosity of the filtrate is adjusted to 3541cps with purified water, and then passed through a nanofiltration membrane. During ...

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Abstract

A method for producing an aseptic bulk drug tylosin salt by utilizing a tylosin fermentation broth is disclosed. The aseptic bulk drug tylosin salt is obtained by performing pretreatment, tubular porous ceramics membrane filtration, dilution, nanofiltration membrane nanofiltration, crystal water washing, acid-base neutralization, ultrafiltration and spray drying on the tylosin fermentation broth. The method helps to realize the stable efficient production of the bulk drug aseptic bulk drug tylosin salt. Also the method helps to simplify the extraction technology, improve the extraction yield of the tylosin salt, shorten the production period, reduce the cost and improve the yield of tylosin. The method helps to simplify the extraction technology of tylosin, shorten the production period by 4 hours or more and improve the extraction efficiency, and has the advantages of being energy-saving, capable of reducing environmental pollution, simple in operation, high in work efficiency and the like.

Description

technical field [0001] The invention belongs to the technical field of extraction and synthesis of veterinary antibiotics, and in particular relates to a method for producing tylosin salt as an aseptic raw material medicine by using tylosin fermentation liquid. Background technique [0002] Tylosin is a macrolide antibiotic obtained by fermentation and extraction of Actinomycetes Streptomyces freundii, including tylosin base, tylosin phosphate and tylosin tartrate kind of form. Tylosin is a high-efficiency, low-residue antibacterial and growth-promoting agent for poultry and livestock. It has a unique curative effect on chicken septicemia, porcine epidemic pneumonia and other diseases, and has obvious promoting effect on the growth of poultry and livestock. As an animal-specific antibiotic, tylosin avoids the problem of cross-resistance caused by shared antibiotics between humans and animals, and is used for the prevention and treatment of swine and poultry mycoplasma dise...

Claims

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Application Information

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IPC IPC(8): C07H17/08C07H1/08
CPCY02P20/10
Inventor 任勇
Owner 宁夏泰瑞制药股份有限公司
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