Method for producing aseptic bulk drug tylosin salt by utilizing tylosin fermentation broth
A technology of tylosin and fermentation broth, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problems of easy emulsification, low extraction yield, easy environmental pollution, etc., and reduce equipment maintenance. cost, simplify the extraction process, and improve the effect of extraction efficiency
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Embodiment 1
[0048] Turn on the fermenter to stir, and the speed is controlled at 10r / min. will be 10m 3 Tylosin fermentation broth (chemical potency 13241μ / ml) was heated up to 50°C, 10kg of industrial oxalic acid was added, and the pH was adjusted to 3.2 with 20% hydrochloric acid, and the stirring was continued for 20 minutes. The fermentation broth is transported to a stainless steel metal mesh with a filtration accuracy of 400 μm by a high-pressure centrifugal pump for filtration, and the tylosin residue is washed with drinking water with a pH of 5-6 (adjusted with 20% hydrochloric acid or sulfuric acid) to obtain Tylosin Su filtrate 8.2m 3 , The chemical titer is 16955μ / ml. The pretreatment yield was 105%.
[0049] The tylosin filtrate was filtered through a tubular porous ceramic membrane. Before the filtrate is filtered, the viscosity of the filtrate is adjusted to 3892 cps with purified water. During the membrane filtration process, the pressure is controlled at 1-1.2 bar, an...
Embodiment 2
[0055] Turn on the fermenter to stir, and the rotating speed is controlled at 20r / min. will be 10m 3 Tylosin fermentation broth (chemical potency 13152μ / ml) was heated to 55°C, 25kg of sodium oxalate was added, and the pH was adjusted to 4.1 with 20% sulfuric acid, and stirring was continued for 25 minutes. The fermentation liquid is transported to a stainless steel metal mesh with a filtration accuracy of 450 μm by a high-pressure centrifugal pump for filtration, and the tylosin residue is washed twice with drinking water with a pH of 5-6 (adjusted with 20% hydrochloric acid or sulfuric acid) to obtain Tylosin Loxacin filtrate 8.4m 3 , The chemical titer is 16503μ / ml. The yield of pretreatment was 105.4%.
[0056] The tylosin filtrate was filtered through a tubular porous ceramic membrane. Before the filtrate is filtered, the viscosity of the filtrate is adjusted to 3725cps with purified water, and then passed through a nanofiltration membrane. During the membran...
Embodiment 3
[0062] Turn on the fermenter to stir, and the rotating speed is controlled at 30r / min. will be 10m 3 Tylosin fermentation broth (chemical potency 130874μ / ml) was heated up to 60°C, 50kg of glutamic acid was added, and the pH was adjusted to 4.9 with 20% hydrochloric acid, and the stirring was continued for 30 minutes. The fermentation broth is transported to a stainless steel metal mesh with a filtration accuracy of 500 μm by a high-pressure centrifugal pump for filtration, and the tylosin residue is washed twice with drinking water with a pH of 5-6 (adjusted with 20% hydrochloric acid or sulfuric acid) to obtain Tylosin Rhizoctin filtrate 8.1m 3 , The chemical titer is 14069μ / ml. The yield of pretreatment is 104.8%.
[0063] The tylosin filtrate was filtered through a tubular porous ceramic membrane. Before the filtrate is filtered, the viscosity of the filtrate is adjusted to 3541cps with purified water, and then passed through a nanofiltration membrane. During ...
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