Insulin nano transdermal patch and preparation method thereof

A technology for insulin and recombinant human insulin, applied in pharmaceutical formulations, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of poor water solubility, low absorption and bioavailability of insulin, and achieve improved efficacy and high drug loading. dose, reducing the effect of drug toxicity and side effects
CN103705494AInactive Publication Date: 2014-04-09HUBEI UNIVERSITY OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUBEI UNIVERSITY OF MEDICINE
Publication Date
2014-04-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an insulin nano transdermal delivery preparation and a preparation method thereof. The insulin nano transdermal delivery preparation takes recombinant human insulin as an active pharmaceutical ingredient and is a filled closed type transdermal preparation consisting of an anti-sticking layer, a drug-loaded layer and a back lining layer. The drug-loaded layer consists of nano recombinant human insulin, a carrier, a penetration enhancer and a plasticizer. The nano recombinant human insulin is obtained by dissolving insulin in a solvent, adding water-soluble auxiliary agents including liposome, chitosan, HPMC (hydroxy propyl methyl cellulose) and the like and an aqueous solution of a freeze-drying protective additive, performing low-temperature high-speed stirring and then performing freeze-drying. The patch disclosed by the invention realizes transdermal noninvasive administration through nano-scale combination of insulin and the carrier to ensure that the bioavailability of the insulin is greatly improved; the patch has the advantages of high transdermal absorption rate, fast response, good treatment effect and good product stability, does not have anaphylactic and toxic reactions to skins, and has the characteristics of good safety, small side effect and convenience in use. The preparation method of the insulin nano transdermal patch disclosed by the invention is simple, low in production cost, and easy to magnify.
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Description

technical field

[0001] The invention relates to an insulin nano transdermal drug delivery preparation and a preparation method thereof. Background technique

[0002] Insulin is a polypeptide hormone secreted by pancreatic β cells, and it is currently the only hormone in the body that can lower blood sugar. The human insulin molecule relies on two disulfide bonds to bind the A chain (21 amino acids) and the B chain (30 amino acids). If the disulfide bond is opened, it will lose its activity. The molecular weight of insulin is about 6000, the isoelectric point is 5.35-5.45, and it is almost insoluble in water, ethanol, chloroform or ether. Insulin preparations include injections, pulmonary inhalation preparations, implants, oral or oral mucosal absorption preparations, etc., among which intramuscular injection (including needle-free injection) is currently the most widely used. Intramuscular injections are generally white or off-white suspensions that separate into layers af...

Claims

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