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Mesoporous calcium magnesium silicate and polyetheretherketone composite, bone prosthesis as well as preparation method and application of composite

A technology of mesoporous calcium magnesium silicate and polyetheretherketone, applied in prosthesis, dental preparation, dental prosthesis, etc., can solve the problems of lack of biological activity, inability to bond firmly, poor mechanical compatibility, etc. Achieve the effects of simple and easy process, good biological activity and biocompatibility

Inactive Publication Date: 2015-04-29
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the loosening and bone resorption of bone repair materials caused by stress shielding caused by the poor mechanical compatibility of existing bone repair materials, or the bone healing speed is too slow and lacks biological activity, which cannot be combined with Defects in the formation of strong bonds in bone

Method used

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  • Mesoporous calcium magnesium silicate and polyetheretherketone composite, bone prosthesis as well as preparation method and application of composite
  • Mesoporous calcium magnesium silicate and polyetheretherketone composite, bone prosthesis as well as preparation method and application of composite
  • Mesoporous calcium magnesium silicate and polyetheretherketone composite, bone prosthesis as well as preparation method and application of composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] A preparation method of mesoporous calcium magnesium silicate, comprising the steps of:

[0069] (1) Mix 6.0g of P123, 217g of water and 6g of absolute ethanol until the solution is clear, add 17mL of hydrochloric acid with a concentration of 11.9mol / L at 38°C and stir and mix, then mix 12.9g of TEOS with 8 Add dropwise / min to 20drop / min into the solution, stir until the solution turns white and turbid, then add 7.3g of calcium nitrate tetrahydrate and 7.9g of magnesium nitrate hexahydrate, and continue stirring for 1 hour to obtain a reaction solution;

[0070] (2) Aging the reaction solution at 95°C for 3 days, then removing the supernatant by suction filtration, drying the precipitate at 80°C, and sintering at 550°C for 6 hours to obtain the obtained product.

[0071] The scanning electron micrographs and transmission electron micrographs of the mesoporous calcium magnesium silicate are shown in figure 1 (a), (b) and figure 1 (c), (d); the mesoporous calcium magnes...

Embodiment 2

[0073] The preparation method of mesoporous calcium magnesium silicate / polyether ether ketone composite material, it comprises the following steps:

[0074] 2kg (20wt%) of the mesoporous calcium magnesium silicate powder prepared in Example 1 and 8kg (80wt%) of polyetheretherketone powder (10 μm in particle size) were uniformly mixed in a mixer to obtain a mixed powder; the mixed powder Mix with absolute ethanol, ultrasonically disperse with 60W power for 15min, and then place in a 60°C oven to evaporate absolute ethanol to obtain a composite powder; then use a mold to compress the composite powder (use a mold for a non-bone prosthetic product), and then Raise the temperature in a sintering furnace, sinter and shape it, and obtain it; wherein, the sintering temperature is 355° C.; the heating rate of the sintering furnace is 1° C. / min; and the holding time is 2 hours. The mechanical properties of the mesoporous calcium magnesium silicate / polyether ether ketone composite are sh...

Embodiment 3

[0076] A method for preparing a bone prosthesis, comprising the steps of:

[0077] 4kg (40wt%) of the mesoporous calcium magnesium silicate powder prepared in Example 1 and 5kg (50wt%) of polyetheretherketone powder (10 μm in particle size) were uniformly mixed in a mixer to obtain a mixed powder; Mix the mixed powder with absolute ethanol, ultrasonically disperse for 30 minutes with a power of 90W, and then place it in an oven at 58°C to evaporate absolute ethanol to obtain a composite powder; then use a mold to press the composite powder into shape (use a mold for non-bone prosthesis products) , and then heated up in a sintering furnace, and sintered to form a final product; wherein, the sintering temperature is 360° C.; the heating rate of the sintering furnace is 2° C. / min; the holding time is 2.5 hours. The mechanical properties of the bone restoration are shown in Table 1.

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Abstract

The invention discloses a mesoporous calcium magnesium silicate and polyetheretherketone composite, bone prosthesis as well as a preparation method and application of the composite. The preparation method of the mesoporous calcium magnesium silicate / polyetheretherketone composite comprises the following steps: uniformly mixing 20-40wt% of mesoporous calcium magnesium silicate and 6-80wt% of polyetheretherketone composite of 10-20microns so as to obtain mixed powder; mixing the mixed powder with absolute ethyl alcohol, ultrasonically dispersing, and evaporating the absolute ethyl alcohol at 58-62 DEG C so as to obtain composite powder; and pressing and molding the composite powder by virtue of a mould pressing method so as to obtain the composite. The mesoporous calcium magnesium silicate is uniform in particle size and is uniform in mesoporous pore size distribution. The composite is good in bioactivity and biocompatibility, relatively good in mechanical compatibility with bone tissue, and capable of stimulating bone growth, accelerating bone healing and shortening healing time of bone after implanting material. The bone prosthesis is good in bone mechanical compatibility and antibacterial property, high in strength, fatigue-resistant, good in corrosion resistance and long in service life.

Description

technical field [0001] The invention relates to the field of materials, in particular to mesoporous calcium magnesium silicate, polyetheretherketone composite material and its preparation method and application, and also relates to a bone restoration and its preparation method. Background technique [0002] At present, the clinically used bone implant materials are mostly titanium-based bone implant materials and ceramic bone implant materials, but these materials still have their own shortcomings that are difficult to overcome. The structural properties of metal materials are quite different from those of bone, lack of biological activity, cannot form osseointegration with bone, and easily cause bone resorption, and the dissolution of metal ions can easily lead to effusion, inflammation, and necrosis; while ceramic bone implant materials have Difficult to form and process, poor toughness and other disadvantages. Therefore, the research and development of new alternative pr...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/18A61K6/02A61K6/087C04B35/16C04B35/622A61K6/891
Inventor 魏杰蔡亮刘昌胜汤晓峰丁月婷陈洁邬迎阳张珏
Owner EAST CHINA UNIV OF SCI & TECH
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