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Cosmetic additives and cosmetics

A technology of cosmetic additives and cosmetics, applied in the direction of cosmetic preparations, cosmetics, dressing preparations, etc., can solve the problems of lack of anti-inflammatory effects, etc., and achieve the effect of eliminating hydroxyl free radical activity, preventing damage, and low price

Active Publication Date: 2019-04-09
SHANGHAI HUIBIXU CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, isomalt was only used as a sweetener, moisture-proof agent, bulking agent, and excipient in the past, and research on its utilization and performance (hydroxyl radical scavenging activity, anti-inflammatory effects, etc.) missing

Method used

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  • Cosmetic additives and cosmetics
  • Cosmetic additives and cosmetics
  • Cosmetic additives and cosmetics

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0036] Experimental Example 1: Evaluation of Hydroxyl Radical Scavenging Activity

[0037]According to the deoxyribose method (Halliwell, 1981), the elimination rate of hydroxyl radicals of isomalt, 6-fructose-α-glucoside, erythritol, xylitol and sorbitol was obtained.

[0038] Specifically, first in purified water, add 33.6mM-deoxyribose (final concentration 4.2mM), 200μL-iron(III) oxide / 1.04mM-EDTA solution (final concentration of Fe is 100μM), 120mM-phosphate buffer (pH7. 4, final concentration 15mM), 1mM-ascorbic acid (final concentration 150μM), 0.02% hydrogen peroxide, 50mM-NaOH, 1%TBA (thiobarbituric acid) / 50mM-NaOH solution, and 2.8%TCA (trichloro Acetic acid), prepared as a reagent. In this reagent, various sugar alcohols (isomalt, isomalt, erythritol, xylitol, sorbitol) are adjusted according to the concentrations shown in Table 1 and Table 2. At the same time, purified water is used in this reagent instead of the sugar alcohol solution as the base liquid.

[0039...

experiment example 2

[0046] Experimental example 2: Verification of the effect of inhibiting the generation of active oxygen on hair

[0047] After the hair is irradiated by ultraviolet rays, it will generate reactive oxygen species such as hydrogen peroxide and hydroxyl radicals, which will cause an oxidation chain reaction to promote the oxidation of cystine to sulfalanine, thereby promoting the formation of disulfide bonds in hair. resulting in damage to the epidermis of the hair. This experiment used the reactive oxygen fluorescence reaction of fluorescein to verify the effect of isomalt and isomalt on the prevention of hair reactive oxygen species. Hydroxyphenyl fluorescein (HPF for short) has no fluorescence in neutral aqueous solution, but after reacting with oxides with the same high reactivity as active oxygen, it generates a strong fluorescent compound fluorescein (excitation wavelength 490nm, fluorescence wavelength 515nm), And an increase in fluorescence intensity can be observed. HP...

experiment example 3

[0051] Experimental Example 3: Verification of the protective effect against hair damage under UV irradiation

[0052] Take 1ml of the aqueous solution mixed with water and 1% isomalt into a 35mm glass shallow dish, and then immerse 10 hairs of healthy women between the ages of 20 and 30 with a length of 1cm, respectively, into the water and 1% isomalt aqueous solution. Separate hair from root to root so they don't overlap. Next, after 20 minutes of UV (wavelength 280-400nm) irradiation from above the glass tray, the state of the cuticle layer of the hair was observed with a microscope and electron micrographs were taken. At the same time, as a comparison reference, the hair without UV irradiation was also observed under a microscope for its epidermis state and microscopic photos were taken. Figure 5 It is a photomicrograph of hair without UV irradiation, Figure 6 It is an electron micrograph after soaking in 1% isomalt aqueous solution and carrying out UV irradiation, ...

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Abstract

The invention discloses an additive for a cosmetic and the cosmetic. The additive for the cosmetic is sugar alcohol which is prepared from equimolar mixtures containing alpha-D-glucopyranose-1,6-sorbitol, alpha-D-glucopyranose-1 and 1-mannitol; and the cosmetic contains the additive for the cosmetic. The additive for the cosmetic and the cosmetic disclosed by the invention have the effects of efficiently eliminating the activity of hydroxyl free radicals; and meanwhile, efficient anti-inflammatory effects can be revealed.

Description

technical field [0001] The invention relates to an additive and cosmetics, in particular to an additive for cosmetics and cosmetics. Background technique [0002] Glycerin, erythritol, xylitol, mannitol, sorbitol, trehalose and many other sugar alcohols are widely used as moisturizers in the field of cosmetics. In particular, erythritol, xylitol, mannitol, and sorbitol are well known for their high ability to eliminate hydroxyl radicals. The use of cosmetics containing such sugar alcohols has a good preventive effect. Causes such as ultraviolet rays, because of the effects of various problems such as hair damage, skin sagging, and wrinkles caused by hydroxyl radicals. [0003] However, in many cosmetics such as shampoo products, shaving creams, and liquid foundations, most of them use a surfactant, sodium dodecyl sulfate (SDS), as an emulsifier, foaming agent, and detergent. As we all know, SDS is easy to cause skin inflammation. In addition, coupled with the activity of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/60A61Q19/00A61P17/18A61P29/00A61P17/00
Inventor 大平淳史李娟娟
Owner SHANGHAI HUIBIXU CHEM CO LTD
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