Preparation method of titanium-niobium-zirconium-based hydroxyapatite biological composite material

A titanium-niobium-zirconium-based hydroxyapatite and composite material technology, applied in medical science, prostheses, etc., can solve the problems of poor elastic modulus, easy peeling off of the coating, long-term biological stability, low compressive strength, etc., and achieve elasticity Low modulus, short sintering time and high density

Active Publication Date: 2015-08-26
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to solve the problems existing in the existing titanium and titanium alloy-based hydroxyapatite composite materials, such as the coating is easy to fall off and the long-term biological stability is poor, and the elastic modulus of the composite material prepared by mixing titanium alloy / ceramic is high, Low compressive strength, etc., provides a preparation method of titanium-niobium-zirconium-based hydroxyapatite biocomposite material, the obtained biocomposite material has the advantages of uniform composition and structure, low elastic modulus, good biological activity, etc., and can be used as artificial Bone tissue repair or replacement material application

Method used

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  • Preparation method of titanium-niobium-zirconium-based hydroxyapatite biological composite material
  • Preparation method of titanium-niobium-zirconium-based hydroxyapatite biological composite material
  • Preparation method of titanium-niobium-zirconium-based hydroxyapatite biological composite material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) According to the mass percentage (wt%) of Ti 65%, Nb 30%, and Zr 5%, respectively weigh Ti, Nb, and Zr metal powders with a purity of 99.5%, 99.95%, and 99% and a particle size of 45 μm ;Put the powder into a ball mill jar for mechanical alloying. During the ball milling process, the ball milling medium is stainless steel balls, the ball-to-material ratio is 3:1, sealed with alcohol and then vacuumed to 30Pa, and then ball milled for 7 hours, the obtained metal mixed powder is still placed in alcohol for later use.

[0023] (2) According to 15% of the mass of the mixed metal powder obtained in step (1), weigh the hydroxyapatite powder with a purity of 97% and a particle size of 100nm, add it to the mixed metal powder for ball milling, seal it with alcohol and pump it. Vacuum at 20 Pa, mix for 1.5 h, and then dry in a vacuum oven at 40°C to obtain a mixed powder.

[0024] (3) Put the mixed powder obtained in step (2) into a graphite mold, then put it into a spark pl...

Embodiment 2

[0027] (1) According to the mass percentage (wt%) of T60%, Nb 34%, and Zr 6%, respectively weigh Ti, Nb, and Zr metal powders with a purity of 99.5%, 99.95%, and 99%, and a particle size of 25 μm; The powder is put into a ball mill jar for mechanical alloying. During the ball milling process, the ball milling medium is stainless steel balls, the ball-to-material ratio is 3:1, sealed with alcohol and then vacuumed to 30Pa, and then ball milled for 8 hours, the obtained metal mixed powder is still placed in alcohol for later use.

[0028] (2) According to 20% of the mass of the mixed metal powder obtained in step (1), weigh hydroxyapatite powder with a purity of 97% and a particle size of 10 μm, add it to the mixed metal powder for ball milling, seal it with alcohol and pump it Vacuum at 25 Pa, mix for 2 h, and then dry in a vacuum oven at 40°C to obtain a mixed powder.

[0029] (3) Put the mixed powder obtained in step (2) into a graphite mold, then put it into a spark plasma ...

Embodiment 3

[0032] (1) According to the mass percentage (wt%) of Ti 67%, Nb 29%, and Zr 4%, respectively weigh Ti, Nb, and Zr metal powders with a purity of 99.5%, 99.95%, and 99%, and a particle size of 30 μm ;Put the powder into a ball mill jar for mechanical alloying. During the ball milling process, the ball milling medium is stainless steel balls, the ball-to-material ratio is 4:1, sealed with alcohol and then vacuumed to 25Pa, and then ball milled for 6 hours, the obtained metal mixed powder is still placed in alcohol for later use.

[0033] (2) According to 10% of the mass of the mixed metal powder obtained in step (1), weigh hydroxyapatite powder with a purity of 97% and a particle size of 20nm, add it to the mixed metal powder for ball milling, seal it with alcohol and pump it Vacuum at 30Pa, mix for 1 h, and then dry in a vacuum oven at 40°C to obtain a mixed powder.

[0034] (3) Put the mixed powder obtained in step (2) into a graphite mold, then put it into a spark plasma...

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Abstract

The invention discloses a preparation method of a titanium-niobium-zirconium-based hydroxyapatite biological composite material and belongs to the field of biomaterial preparation. The composite material of the invention employs titanium-niobium-zirconium alloy as a matrix, and hydroxyapatite as a bio-ceramic; and the weight of hydroxyapatite is 10-25% of that of the titanium alloy. The preparation process is as follows: filling a hydroxyapatite powder and a titanium alloy powder into a mill pot, sealing by alcohol, vacuumizing to 20-30Pa, milling for 6-8 h and drying in a vacuum oven; filling the dry powder into a graphite mold for cold forming; and finally carrying out spark plasma sintering with the sintering temperature at 1100 DEG C-1200 DEG C, first heating to 1000 DEG C by heating rate of in 100 DEG C / min, then heating to the sintering temperature by 25-50 DEG C / min and insulating for 6-10min with the pressure of 50-60MPa. The prepared biological composite material has elastic modulus of 25.4-45GPa, and has good mechanical properties and biocompatibility. The method of the invention is simple in process and low in production cost.

Description

technical field [0001] The invention relates to a method for preparing a titanium-niobium-zirconium-based hydroxyapatite biocomposite material, in particular to a method for preparing a titanium alloy-based hydroxyapatite biocomposite material by using spark plasma sintering technology, which belongs to the technical field of biomedical material preparation . Background technique [0002] Titanium niobium zirconium biomedical titanium alloys such as Ti-34Nb-6Zr, Ti-30Nb-5Zr-5Ta, Ti-29Nb-4.6Zr-13Ta, etc. have low elastic modulus, high specific strength, good wear resistance and corrosion resistance and biological Compatibility and other advantages, it is one of the most promising new materials for human body replacement and repair. However, biomedical titanium alloy is an inert material with no biological activity on the surface and lack of active repair function. After implanted in the human body, the surface of the titanium alloy and the body tissue are simply interlocked ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/50C22C1/05
Inventor 张玉勤何正员何远怀蒋业华周荣
Owner KUNMING UNIV OF SCI & TECH
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