Method for synthesizing n-propylbenzene through Grignard reagent method

A technology of Grignard reagent and n-propylbenzene, which is applied in the field of synthesizing n-propylbenzene, can solve the problems of expensive ethyl lithium, harsh reaction conditions, and long reaction time, and achieve low production cost, few side reactions, and simple reaction Effect

Active Publication Date: 2015-09-09
山东东昌精细化工科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can be seen that the reaction time of this method is longer, and a variety of reagents are used in the reaction, the production cost is higher, and a large amount of aluminum-containing wastewater will be produced, which has a greater impact on the environment
[0009] In addition, n-propylbe

Method used

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  • Method for synthesizing n-propylbenzene through Grignard reagent method
  • Method for synthesizing n-propylbenzene through Grignard reagent method
  • Method for synthesizing n-propylbenzene through Grignard reagent method

Examples

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Example Embodiment

[0031] Example 1: Diethyl ether is used as solvent, benzyl chloride is reacted with magnesium powder, and then reacted with diethyl sulfate to synthesize n-propylbenzene. The specific steps are as follows:

[0032] In a 500ml four-necked glass flask with a reflux device, a thermometer, a heating device, a stirring device, and a constant pressure dropping funnel, add 5.2g of magnesium powder (0.22mol, 10% excess) and 30ml of ether; then add benzyl chloride 26.58 grams (0.2 mol) and 70 ml of ether were mixed to form a benzyl chloride solution, then added to a constant pressure dropping funnel, and 5 ml of benzyl chloride solution was added dropwise to the flask; 1 grain of iodine was added to the flask. The heating initiates the Grignard reaction, and the stirring is started to fully mix the contents of the flask. Add the remaining benzyl chloride solution dropwise to the flask and adjust the dropping rate so that the solvent in the material is in a slow reflux state.

[0033] After...

Example Embodiment

[0035] Example 2: On the basis of Example 1, the solvent was changed to tetrahydrofuran. The result of the reaction (deducting the ether solvent peak): toluene 8%, n-propylbenzene 70%, and diphenylethane 11%. Tetrahydrofuran has a high boiling point, so that the reaction temperature increases, the selectivity of n-propylbenzene becomes better, and the coupling of benzyl chloride itself accelerates, and the content of diphenylethane by-products also increases.

Example Embodiment

[0036] Example 3: On the basis of Example 1, the solvent was changed to a mixed solvent of diethyl ether and tetrahydrofuran (50% each), the reaction result was (deducting the ether solvent peak): toluene 9%, n-propylbenzene 74%, diphenyl ethyl Alkane 8%.

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Abstract

The invention relates to a method for synthesizing n-propylbenzene through a Grignard reagent method. The technical scheme comprises that in an ether solvent, benzyl chloride reacts with magnesium powder or magnesium strip to produce a benzyl magnesium chloride Grignard reagent, and the benzyl magnesium chloride Grignard reagent reacts with an ethylation reagent to produce n-propylbenzene. Compared with the method in the prior art, the method for synthesizing the n-propylbenzene by using the Grignard reagent method in the present invention has the following advantages that (1) the reaction is simple, the used reagents are less, and the operation is easy; (2) the pollutants are less, and the method does not produce a lot of aluminum-containing wastewater; (3) the reaction temperature is low and is usually not more than 100 DEG C, the energy consumption is low, and the method does not required the heating evaporation of a large amount of water in the F-C method; and (4) the raw materials are easy to obtain, the yield is high, the side effects are less, and the production cost is low.

Description

technical field [0001] The invention relates to the field of chemical synthesis methods, in particular to a new method for synthesizing n-propylbenzene. technical background [0002] N-propylbenzene (also called n-propylbenzene, propylbenzene) is an aromatic hydrocarbon compound in which one hydrogen atom on the benzene ring is replaced by n-propyl. [0003] N-propylbenzene English name: Propylbenzene or n-Propylbenzene [0004] Molecular Structure: or [0005] Molecular formula: C 9 h 12 , Molecular weight: 120.19, CAS registration number: 103-65-1, density: 0.862, boiling point: 158°C, flash point: 47°C, melting point: -99°C, refractive index: 1.49-1.493. [0006] N-propylbenzene is a colorless liquid at normal temperature and pressure, slightly soluble in water, and soluble in aromatic hydrocarbons, ethanol, ether and other organic solvents. In chemical production, it can be used as solvent or organi...

Claims

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Application Information

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IPC IPC(8): C07C15/02C07C1/32
Inventor 司志华孙海洋焦鹏飞于娜
Owner 山东东昌精细化工科技有限公司
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