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L-(+)-tartaric acid clean production process based on bipolar membrane electroosmosis technology

A technology of tartaric acid and sodium tartrate, which is applied in carboxylate preparation, organic chemistry, fermentation, etc., can solve the problems of low production efficiency, unsatisfactory output, and different content, so as to improve production efficiency, avoid cumbersome production steps, and significantly industrialize Effect of application value and environmental benefits

Inactive Publication Date: 2015-11-25
THE GREAT WALL BIO CHEM ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, although potassium hydroxide is used to convert potassium hydrogen tartrate in tartar into potassium tartrate with higher solubility before extraction, due to the permeation of ions by anion exchange membrane and cation exchange membrane Different properties, it is also easy to form potassium hydrogen tartrate with low solubility (under the condition of 25 ℃, the solubility is only about 8g / L), which will lead to membrane clogging, which is not conducive to industrial use; in order to avoid unfavorable factors such as membrane clogging, The concentration of tartrate ions in the solution must be kept at a low level, resulting in low conductivity, requiring special conductive separators; and its production efficiency is also low
At the same time, affected by grape yield, production area and season, the content of potassium hydrogen tartrate in grapes in different regions is different, which is not conducive to industrial production, and its output cannot meet the needs of modern industry

Method used

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  • L-(+)-tartaric acid clean production process based on bipolar membrane electroosmosis technology
  • L-(+)-tartaric acid clean production process based on bipolar membrane electroosmosis technology
  • L-(+)-tartaric acid clean production process based on bipolar membrane electroosmosis technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In the following examples 2-4, the model of the bipolar membrane electrodialyzer used is CJ-BMED-A, produced by Hefei Kejia Polymer Material Technology Co., Ltd., with an overall size of 650×650×950mm, and a membrane stack The size is 170mm×110mm, and the ion exchange membrane is acid and alkali resistant. Preparation of Example 1 L-type cis-epoxysuccinate hydrolase and its enzymatic hydrolysis

[0036] The gene fragment of SEQ ID NO: 1 was connected to the pBV220 plasmid vector, and then the recombinant plasmid was introduced into E.coliBL21 (DE3) competent cells to obtain recombinant L-type cis-epoxysuccinate hydrolase engineering bacteria. The cultivation conditions of engineering bacteria are as follows: put 100mL of LB medium in a 500mL Erlenmeyer flask, pick a single colony of engineering bacteria and insert it into the medium, place it at 37°C and shake it at 200rpm. When OD600=0.6-0.8, set the temperature After raising the temperature to 42°C for 5 hours, the i...

Embodiment 2

[0038] Example 2 Salt / acid two-chamber electrodialysis device prepares L-(+)-tartaric acid

[0039] 2L is pumped into the salt chamber of salt / acid two-chamber electrodialyzer ( figure 2 ), while pumping 0.5L of 0.2M L-(+)-tartaric acid solution into the acid chamber at a rate of 40L / h to increase its conductivity. The voltage is controlled to maintain the current density at 140mA / cm2, the operating temperature is 50°C, and the cycle reaction is 6h. The conversion rate of L-(+)-tartrate reaches 90%, the energy consumption is 2.13kW h / kg, and the current efficiency is 87 %, the recovery rate of L-(+)-tartaric acid reached 96%.

Embodiment 3

[0040] Example 3 Acid / salt / alkali three-chamber electrodialysis device prepares L-(+)-tartaric acid

[0041] 2L is pumped into the salt chamber of acid / salt / alkali three chamber type electrodialyzer ( image 3 ), while pumping 1L0.2M L-(+)-tartaric acid solution into the acid chamber at a speed of 60L / h, and pumping 1L0.1M NaOH solution into the alkali chamber at a speed of 60L / h to increase its conductivity . Control the voltage to maintain the current density at 80mA / cm 2 , the operating temperature is 40°C, the cycle reaction is 6h, the conversion rate of L-(+)-tartrate reaches 95%, the energy consumption is 2.43kW h / kg, the current efficiency is about 89%, and the L-(+)-tartaric acid The recovery rate reaches 98%.

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Abstract

A purpose of the present invention is to provide a L-(+)-tartaric acid clean production process based on a bipolar membrane electroosmosis technology. The process comprises that: a cis-epoxy succinic acid sodium salt is hydrolyzed with L-type cis-epoxy succinic acid hydrolase (D-ESH) to obtain a L-(+)-sodium tartrate conversion solution; and the L-(+)-sodium tartrate contained in the L-(+)-sodium tartrate conversion solution is converted into L-(+)-tartaric acid through a bipolar membrane electordialyzer. According to the present invention, the current L-(+)-calcium tartrate acidification process can be replaced, the L-(+)-tartaric acid yield achieves more than or equal to 96%, and the additional acid is not required to provide H<+>; the generated NaOH solution can be used for synthesizing the precursor cis-epoxy sodium succinate, and the whole production process does not produce acid, alkali and salt waste solutions; and the production process has characteristics of environmental pollution reducing, raw material consumption reducing, significant industrial application values, and significant environmental benefits.

Description

technical field [0001] The invention relates to a clean production process of L-(+)-tartaric acid, in particular to the application of a bipolar membrane electrodialyzer to separate L-(+)- A method for tartrate ions belongs to the field of membrane technology. Background technique [0002] L-(+)-tartaric acid is a natural organic acid widely distributed in nature, especially in grapes and tamarind fruit. L-(+)-tartaric acid is an important food additive and chemical raw material. As a food additive, L-(+)-tartaric acid can be used as a sour agent, preservative and emulsion stabilizer; in industry, it is mainly used as a dye resist for printing and dyeing, a photographic developer, and a metal ion concealer; in the pharmaceutical industry, it can be used As a drug resolving agent, especially in the production process of the anti-tuberculosis drug ethambutol, L-(+)-tartaric acid has been successfully applied as the only and irreplaceable chiral resolving agent; L-(+) - Tart...

Claims

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Application Information

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IPC IPC(8): C12P7/46C07C59/255C07C51/02
Inventor 周铁成王云山王自强周煜昊冯晓东龚树
Owner THE GREAT WALL BIO CHEM ENG CO LTD
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