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A kind of au@cu2-δx nanocrystal, its preparation method and application

A nanocrystal and volumetric technology, applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problems of low sulfide absorption, lower light-to-heat conversion efficiency, etc., and achieve the effect of mild reaction conditions

Active Publication Date: 2019-01-29
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the current photothermal conversion materials have defects in photothermal conversion efficiency and biocompatibility: first, noble metals are heavy metals, which have certain biological toxicity, and their surfaces need to be modified or modified before they can be used in cancer photothermal therapy , such as coating SiO on the surface of Au nanorods 2 etc.; secondly, the absorption of copper sulfide in the near-infrared is low, which reduces the overall photothermal conversion efficiency
Although it has been reported to combine different copper sulfides and noble metals such as Au to form heterojunction structures, these heterojunction structures have not completely solved the two defects of photothermal conversion materials at present.
[0005] At present, in the photothermal reagent synthesis, there is still no way to combine Au and Cu 2-δ X, X=S, Se or Te, forming a uniform and controllable core-shell nanocrystal structure, forming a photothermal with high absorption coefficient in the near-infrared lesion window, high photothermal conversion efficiency, adjustable absorption band, and low toxicity Reagent

Method used

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  • A kind of au@cu2-δx nanocrystal, its preparation method and application
  • A kind of au@cu2-δx nanocrystal, its preparation method and application
  • A kind of au@cu2-δx nanocrystal, its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0063] 1. Preparation of granular Au@CdS nanocrystals

[0064] (1) Stir 0.72mL of oleic acid, 1mL of 1mol / L sodium hydroxide solution, 4mL of acetonitrile and 4mL of water at room temperature, then add chloroauric acid (HAuCl 4 4H 2 (2) 20 mg, stirred to form a uniform transparent microemulsion, added 80 μL of 0.1mol / L ascorbic acid solution and 13 mL of cyclohexane, and continued to stir for 6 h, left to stand, after layering, take the organic layer liquid; add ethanol to the organic layer liquid 39mL, and centrifuged at 2000rpm for 7min to obtain 4nm granular Au nanocrystals;

[0065] (2) Disperse the granular Au nanocrystals in 20mL of toluene to obtain the granular Au nanocrystal sol, the concentration is 1mg / mL, take 8mL of the granular Au nanocrystal sol, add 0.2mL of oleylamine, 10mg / mL silver nitrate methanol After the solution was 1 mL, it was sealed in a 20 mL capacity screw bottle, heated to 60°C in an oil bath, and kept at a constant temperature for 16 hours to o...

Embodiment 2

[0079] 1. Preparation of granular Au@CdS nanocrystals

[0080] (1) At room temperature, stir 0.72mL of oleic acid, 1mL of 1mol / L sodium hydroxide solution, 4mL of acetonitrile and 4mL of water evenly, then add 20mg of chloroauric acid and stir to form a uniform transparent microemulsion, add 0.1mol / L 80μL of ascorbic acid solution and 13mL of cyclohexane, and continue to stir for 6h, add 4mg of chloroauric acid, 40μL of 0.1mol / L ascorbic acid solution, continue to stir for 3h; stand still, take the organic layer liquid after layering; add to the organic layer liquid 39 mL of absolute ethanol, and centrifuged at 2000 rpm for 7 min to obtain 5 nm granular Au nanocrystals;

[0081] (2) Disperse the granular Au nanocrystals in 40mL of toluene to obtain the granular Au nanocrystal sol, the concentration is 1mg / mL, take 8mL of the granular Au nanocrystal sol, add 0.2mL of oleylamine, 10mg / mL silver nitrate methanol After 1mL of the solution was sealed in a 20mL screw bottle, the oi...

Embodiment 3

[0095] 1. Preparation of granular Au@CdS nanocrystals

[0096] (1) At room temperature, stir 0.72mL of oleic acid, 1mL of 1mol / L sodium hydroxide solution, 4mL of acetonitrile and 4mL of water evenly, then add 30mg of chloroauric acid and stir to form a uniform transparent microemulsion, add 0.1mol / L 80 μL of ascorbic acid solution and 13 mL of cyclohexane, and continue to stir for 6 hours, add 8 mg of chloroauric acid, 40 μL of 0.1 mol / L ascorbic acid solution, continue to stir for 3 hours, stand still, take the organic layer liquid after layering; add to the organic layer liquid Ethanol 39mL, and with 2000rpm centrifugal 7min, obtain the granular Au nanocrystal of 8nm;

[0097] (2) Disperse the granular Au nanocrystals in 30mL of toluene to obtain the granular Au nanocrystal sol, the concentration is 1mg / mL, take 8mL of the granular Au nanocrystal sol, add 0.2mL of oleylamine, 10mg / mL silver nitrate methanol After 1mL of the solution was sealed in a 20mL screw bottle, the o...

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Abstract

The invention relates to an Au@Cu2-deltaX nanoscale crystal and a preparation method and application thereof and belongs to the field of nanoscale materials. The crystal is the nanoscale crystal of a core-shell structure, Au serves as the core, Cu2-deltaX serves as the shell, X is S, Se or Te, and delta is 0-1. The method comprises the steps that Au@CdX nanoscale crystals are dispersed in a non-polar organic solvent, tetrakiscopper hexa-fluorophosph (I) or a solution thereof is added, and reaction liquid is obtained after even mixing; and absolute ethyl alcohol is added for precipitation and centrifugalization to obtain the crystal. The crystal can be applied to the fields of photo-thermal conversion, cancer photo-thermal treatment and the like. The crystal has high light absorptivity and high photo-thermal conversion coefficient at a near infrared region and fills in the technical blank of bimodal surface plasmon resonance (SPR) coupled photo-thermal conversion composite materials. The method can be used for adjusting the size, morphology and the shell layer chemical constituents of the crystal, the conditions are mild, easy and feasible, and a crystal absorption spectrum can be adjusted in a visible light-near infrared light region.

Description

technical field [0001] The present invention relates to a kind of Au@Cu 2-δ X nanocrystal, its preparation method and application, in the nanocrystal, X is a chemical element: sulfur (S), selenium (Se) or tellurium (Te), and δ is 0 to 1; the preparation method is to use ion exchange method, mixing Au@CdX nanocrystals with an organic alcohol solution of Cu(I) salt to obtain the nanocrystals, the preparation method can control the size, shape and Cu of the nanocrystals 2-δ The non-stoichiometric ratio of the X shell layer; the nanocrystal can be applied to fields such as photothermal conversion and cancer photothermal therapy; it belongs to the field of nanomaterials. Background technique [0002] Today, how to cure tumors and cancers has become one of the most difficult and urgent medical problems facing mankind; and photothermal therapy proposed in recent years is one of the possible effective methods. The photothermal therapy reagent required by photothermal therapy needs...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F1/02B82Y30/00B82Y40/00
Inventor 张加涛纪穆为徐萌黄柳刘啸
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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