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A kind of artificial bone scaffold composite material based on kangaroo bone and its preparation method

A composite material and artificial bone technology, applied in the field of polymer materials and biomedical materials, can solve the problems of weak compressive strength, secondary injury to the patient's body, insufficient mechanical strength of the stent, etc., to enhance the elastic modulus and avoid stress shielding. , the effect of overcoming mechanical defects

Active Publication Date: 2018-09-18
杭州夏尔电子科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degradation rate of the current scaffold material cannot be adapted to the formation rate of new tissue; the scaffold material is not suitable for the natural environment of chondrocyte growth; the mechanical strength of the scaffold is not enough, etc.
Traditional synthetic implants such as titanium alloy artificial bones often require secondary surgery to remove them, causing secondary damage to the patient's body
Although the existing PLA / PLGA and PLA / PLGA / TCP artificial bone scaffolds have good bioactivity and biocompatibility, their compressive strength is relatively weak; research on how to overcome mechanical defects while maintaining biocompatibility, Its porous scaffold structure can combine with osteoblasts to promote physiological bone remodeling, which is an important topic in the fields of medicine and biomaterials science

Method used

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  • A kind of artificial bone scaffold composite material based on kangaroo bone and its preparation method
  • A kind of artificial bone scaffold composite material based on kangaroo bone and its preparation method
  • A kind of artificial bone scaffold composite material based on kangaroo bone and its preparation method

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Experimental program
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Effect test

Embodiment 1

[0053] 1. The production process of kangaroo bone dry powder

[0054] Step 1: Protein Removal from Kangaroo Femur:

[0055] First, wash the fresh kangaroo femur with clean water, then soak it with 0.8mol / L hydrochloric acid for 1 hour, and then use 4M guanidine hydrochloride solution to dissolve the protein (among them, guanidine hydrochloride is a strong denaturant, which can dissolve the kangaroo femur. of protein). Then cook in boiling water at 100°C for 3 hours. The purpose of boiling is to remove the meat and other substances in the kangaroo bones, then wash the kangaroo femur with distilled water, and put it in a drying oven to keep the temperature at 110°C for about 28 hours, make the kangaroo bones completely dry and then put them into the freezer for 3 hours;

[0056] The second step: calcining it at a temperature of 80°C for 2 hours, increasing the temperature to 20°C / min during the calcination process, and cooling at room temperature for 2 hours;

[0057] Step 3:...

Embodiment 2

[0071] 1. The production process of kangaroo bone dry powder

[0072] Step 1: Protein Removal from Kangaroo Femur:

[0073] First, wash the fresh kangaroo femur with water, then soak it in 0.5mol / L hydrochloric acid for 2 hours, and then dissolve the protein with 6M guanidine hydrochloride solution. Then boil it in boiling water at 100°C for 4 hours, then wash the kangaroo femur with distilled water, put it in a drying box and keep the temperature at 110°C for about 30 hours, make the kangaroo bone completely dry, and then put it in the freezer for 5 hours ;

[0074] The second step: calcining it at a temperature of 65°C for 3 hours, increasing the temperature to 20°C / min during the calcination process, and cooling at room temperature for 2 hours;

[0075] Step 3: Grind into very fine powder particles with a ceramic mortar grinder. The grinder is a TM130 solid particle grinder. Set at 45 minutes. The particle size of kangaroo femur powder is less than 30 μm.

[0076] 2. C...

Embodiment 3

[0081] 1. The production process of kangaroo bone dry powder

[0082] Step 1: Protein Removal from Kangaroo Femur:

[0083] First, wash the fresh kangaroo femur with clean water, then soak it in 1mol / L hydrochloric acid for 1 hour, and then use 5M guanidine hydrochloride solution to dissolve the protein. Then boil it in boiling water at 100°C for 3.5 hours, then wash the kangaroo femur with distilled water, put it in a drying oven and keep the temperature at 110°C for about 29 hours, make the kangaroo bone completely dry, and then put it in the freezer for 4 hours ;

[0084] The second step: calcining it at a temperature of 90°C for 2.5 hours, increasing the temperature to 20°C / min during the calcination process, and cooling at room temperature for 2 hours;

[0085] Step 3: Grind into very fine powder particles with a ceramic mortar grinder. The grinder is a TM130 solid particle grinder. Set at 35 minutes. The particle size of kangaroo femur powder is less than 30 μm.

[...

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Abstract

The invention discloses an artificial bone scaffold composite material based on kangaroo bone and a preparation method of the artificial bone scaffold composite material. The material is a blended material composed of kangaroo bone powder, calcium pyrophosphate Ca2P2O7, a pore-forming agent, a solvent, a catalytic curing agent and a bonding agent. The method comprises the following steps of adding dry kangaroo bone powder, the calcium pyrophosphate, the pore-forming agent, the solvent, the catalytic curing agent and the bonding agent into a mixing-type torque rheometer for fusion and smelting till a torque is balanced, thereby obtaining the artificial bone scaffold composite material based on the kangaroo bone; finally obtaining an artificial bone scaffold through a 3D (three-dimensional) fused deposition modeling technology. The artificial bone scaffold based on the kangaroo bone disclosed by the invention has the advantages that the biocompatibility is kept and the mechanical defects are conquered at the same time; compared with the existing PLA / PLGA, PLA / PLGA / TCP (polylactic acid / poly(lactic-co-glycolic acid) / tertiary calcium phosphate) artificial bone scaffolds, the rigidity, hardness and elastic modulus of the artificial bone scaffold based on the kangaroo bone are all enhanced.

Description

technical field [0001] The invention belongs to the technical field of polymer materials and biomedical materials, and in particular relates to a kangaroo bone-based artificial bone scaffold composite material with simple preparation, good compressive strength and biocompatibility and a preparation method thereof. Background technique [0002] Artificial bone substitute material transplantation to repair bone defects has become a medical focus. An artificial bone scaffold with excellent performance must meet a certain mechanical strength to avoid internal cell damage; a porous three-dimensional structure is conducive to cell attachment and growth; the degradation cycle of the scaffold material is equivalent to that of bone healing, and requires good biocompatibility . The degradation rate of the current scaffold material cannot adapt to the formation rate of new tissue; the scaffold material is not suitable for the natural environment of chondrocyte growth; the mechanical s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/12A61L27/56A61L27/50A61L27/20
CPCA61L27/12A61L27/20A61L27/3608A61L27/3687A61L27/50A61L27/56A61L2430/02A61L2430/40C08L5/04
Inventor 鄢腊梅袁友伟李黎李金城李鹏伟刘翊
Owner 杭州夏尔电子科技有限公司
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