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Tablet for treating radiation thyroiditis and preparation method thereof

A thyroiditis and radioactive technology is applied in the field of tablets for the treatment of radiation thyroiditis and the field of preparation thereof to achieve the effects of enhancing body immunity, stabilizing drug efficacy, and improving local microcirculation and nutrient supply

Inactive Publication Date: 2016-09-21
张金凤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current drug treatment is mainly to take antibiotics, which can alleviate and eliminate the symptoms of exacerbation, but it is highly dependent on the body’s immune ability, and when the curative effect is slow, it will cause thyroid cancer cells to become lesions. Therefore, a drug that can relieve symptoms Neck discomfort, pressure, local pain in the thyroid gland, dysphagia, fever, fatigue, palpitation and other clinical symptoms can also enhance the body's immunity and prevent cell canceration. This is a major problem in the field of radiation disease drug research.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A tablet for the treatment of radiation thyroiditis, said tablet, by weight, mainly comprises: 1.0 part of hydrocortisone, 0.8 part of cyclosporine, 0.6 part of emodin, 0.3 part of cefotiam axetil, naphthalene Bumethone 0.5 parts, lentinan 2.4 parts, naringin 1.2 parts, Triticein 0.6 parts, Syringic acid 0.3 parts, Glycopeptides 4.2 parts, Vitamin K1 0.1 parts, Peonyol 0.6 parts, Succinic acid 0.5 parts, Vitamins E0.6 parts and 8 parts of hydroxypropyl methylcellulose; the tablet also includes auxiliary materials: 55 parts of fillers, 0.8 parts of disintegrants, and 1.2 parts of lubricants.

[0017] Among them, the filler lactose, microcrystalline cellulose or beta cyclodextrin one or a mixture of several, without toxic side effects, is a commonly used tablet additive. The disintegrant is one or a mixture of crospovidone, sodium carboxymethyl starch, or calcium carboxymethyl cellulose, which exerts strong swelling properties during the preparation of the drug, and is compa...

Embodiment 2

[0023] A tablet for the treatment of radiation thyroiditis, said tablet, in terms of weight components, mainly comprises: 2.0 parts of hydrocortisone, 1.0 part of cyclosporin, 0.8 part of emodin, 0.4 part of cefotiam axetil, naphthalene 0.65 parts of Bumethone, 3.0 parts of lentinan, 1.5 parts of Naringin, 0.9 parts of Tritice, 0.45 parts of Syringic acid, 5.5 parts of Glycopeptides, 0.2 parts of Vitamin K1, 0.7 parts of Peonyol, 0.7 parts of Succinic Acid, Vitamins E0.7 parts and 10 parts of hydroxypropyl methylcellulose; the tablet also includes auxiliary materials: 65 parts of filler, 1.0 part of disintegrant, and 1.4 parts of lubricant.

[0024] Among them, one or more of the fillers lactose, microcrystalline cellulose or betacyclodextrin are mixed without toxic and side effects, and are commonly used tablet additives. The disintegrant is one or a mixture of crospovidone, sodium carboxymethyl starch, or calcium carboxymethyl cellulose, which exerts strong swelling properties ...

Embodiment 3

[0030] A tablet for the treatment of radiation thyroiditis, said tablet, in terms of weight components, mainly comprises: 3.0 parts of hydrocortisone, 1.2 parts of cyclosporine, 1.0 part of emodin, 0.5 part of cefotiam axetil, naphthalene 0.8 parts of bumethone, 3.6 parts of lentinan, 1.8 parts of naringin, 1.2 parts of Triticein, 0.6 parts of syringic acid, 6.8 parts of glycopeptides, 0.3 parts of vitamin K1, 0.8 parts of peonyol, 0.9 parts of succinic acid, vitamins 0.8 parts of E and 12 parts of hydroxypropyl methylcellulose; the tablet also includes auxiliary materials: 75 parts of fillers, 1.2 parts of disintegrants, and 1.6 parts of lubricants.

[0031] Among them, one or more of the fillers lactose, microcrystalline cellulose or betacyclodextrin are mixed without toxic and side effects, and are commonly used tablet additives. The disintegrant is one or a mixture of crospovidone, sodium carboxymethyl starch, or calcium carboxymethyl cellulose, which exerts strong swelling p...

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PUM

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Abstract

The invention discloses a tablet for treating radiation thyroiditis and a preparation method thereof. The mainly components of the tablet comprise: hydrocortisone, cyclosporine, rheum emodin, cefotiam hexetil, nabumetone, lentinan, naringin, tricin, syringic acid, glycopeptide, vitamin K1, paeonol, succinic acid, vitamin E, and hydroxypropyl methyl cellulose. The tablet also comprises the auxiliary materials: filler, disintegrating agent, and lubricating agent. The tablet has good effects of antisepsis and anti-inflammation, sedation-analgesia, and anti-dropsy, can adjust the stimulation of adrenal corticosteroid hormone effectively to reduce the radioactive damage for people by the ionizing radiation, can improve the human body's immunocompetence, can fight against the stimulus response of the bacterial endotoxin for the body, can reduce the cellular damage, can protect the body, has stable pesticide effect and small toxic and side effect, and has good clinical effect for the treatment of the radiation thyroiditis.

Description

Technical field [0001] The invention relates to the technical field of medication for radiation diseases, in particular to a tablet for treating radiation thyroiditis and a preparation method thereof. Background technique [0002] Radiation thyroiditis is a disease in which the thyroid gland has varying degrees of inflammatory lesions due to ionizing radiation, which mainly causes different changes in thyroid function and corresponding clinical symptoms. The clinical symptoms exhibited have individual differences, which are related to the type of radioactive material, the release time, and individual differences such as age, gender, and genetics. Hypothyroidism is the most common manifestation of direct radiation damage to the thyroid. The clinical symptoms of radiation thyroiditis are mostly hyperthyroidism, hypothyroidism, and thyroid pain. Large doses of ionizing radiation on the thyroid in childhood can cause thyroid nodules and thyroid tumors. Radiation thyroiditis is divid...

Claims

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Application Information

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IPC IPC(8): A61K38/13A61K9/28A61K47/38A61P5/14A61P5/16A61K36/48A61K31/715A61K31/7048A61K31/573A61K31/355A61K31/352A61K31/194A61K31/122A61K31/12A61K31/192A61K31/546
CPCA61K9/2054A61K9/28A61K31/12A61K31/122A61K31/192A61K31/194A61K31/352A61K31/355A61K31/546A61K31/573A61K31/7048A61K31/715A61K36/48A61K38/13A61K2300/00
Inventor 张金凤
Owner 张金凤
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