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Hydrogel sustained-release carrier for oral drugs as well as preparation method and application of hydrogel sustained-release carrier

A slow-release carrier and hydrogel technology, which can be used in drug combination, drug delivery, and pharmaceutical formulations, etc. It can solve the problems of easily residual initiators and cross-linking agents, calcium alginate is not easily soluble in water, and poor biocompatibility , to achieve excellent biocompatibility and degradation performance, excellent tissue compatibility, and optimized performance

Inactive Publication Date: 2016-11-16
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN103467755A discloses "a drug slow-release hydrogel and its preparation method and application". The high-voltage electrostatic droplet method is used to prepare monodisperse drug-containing calcium alginate microspheres, and then the drug-loaded calcium alginate microspheres are placed in the In the hydrogel network structure, so as to realize the sustained release of drugs, it has good elasticity, water absorption and water retention, air permeability and other properties; but calcium alginate is not easy to dissolve in water, and its preparation process is cumbersome
CN101214217A discloses "hydrogel-hydrogel composite material and its preparation method and drug slow-release matrix application", although it is convenient to carry and use, and has a long storage time, its application range is small, and it is only suitable for slow-release of corneal contact lenses Eye drops; and the initiator and cross-linking agent are easy to remain in the carrier, and the biocompatibility is poor
Injectable sodium alginate / sulfurized fructose-chitosan composite hydrogel prepared as an oral carrier of protein drugs by Zhang Yinye et al. Gel, when the pH value is 6.8 and 7.4, the release rate of bovine serum albumin (BSA) increases, and can be used as a kind of oral protein drug carrier, but the process that chitosan is converted into sulfurated fructose-chitosan is relatively difficult. complex

Method used

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  • Hydrogel sustained-release carrier for oral drugs as well as preparation method and application of hydrogel sustained-release carrier
  • Hydrogel sustained-release carrier for oral drugs as well as preparation method and application of hydrogel sustained-release carrier
  • Hydrogel sustained-release carrier for oral drugs as well as preparation method and application of hydrogel sustained-release carrier

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The degree of deacetylation of the chitosan is greater than 85%, and the purity of the dialdehyde starch, gelatin and polyvinyl alcohol all reach the pharmaceutical standard. 2g chitosan, 2g dialdehyde starch, 2g gelatin, and 2g polyvinyl alcohol were dissolved in 50g deionized water respectively, and the prepared chitosan solution, dialdehyde starch solution, gelatin solution, and polyvinyl alcohol solution were mixed in 5: The volume ratio of 0.8:3:0.5 is mixed evenly. Put the prepared solution into an acidic aqueous solution with a pH of 3.0 to catalyze cross-linking, and obtain a hydrogel after standing for 5 minutes, soak it in deionized water several times to neutrality, and obtain a finished hydrogel, freeze-dry it, and The dried hydrogel was analyzed by infrared spectroscopy (results are attached figure 1 ). It can be seen from the figure that at 1450-1670cm -1 The vibrational peaks of , confirm the presence of Schiff bases (i.e., imine bonds), proving the fo...

Embodiment 2

[0029] 2g chitosan, 2g dialdehyde starch, 2g gelatin, and 2g polyvinyl alcohol were dissolved in 50g deionized water respectively, and the prepared chitosan solution, dialdehyde starch solution, gelatin solution, and polyvinyl alcohol solution were mixed in 5: The volume ratio of 1.2:3.5:0.6 is mixed evenly. Add the prepared solution to an acidic solution with a pH of 4.0 to catalyze it. After standing for 5 minutes, a hydrogel is obtained. Soak it in deionized water until neutral to obtain a finished hydrogel. After freeze-drying, it will be brittle after cooling with liquid nitrogen. , exposed the section, and analyzed the hydrogel section by scanning electron microscopy (results are shown in the attached figure 2 ). It can be seen from the figure that the cross-section of the hydrogel is a multilayer structure with a large number of cavities, which proves that the hydrogel has excellent water absorption and swelling properties.

Embodiment 3

[0031] 2g chitosan, 2g dialdehyde starch, 2g gelatin, and 2g polyvinyl alcohol were dissolved in 50g deionized water respectively, and the prepared chitosan solution, dialdehyde starch solution, gelatin solution, and polyvinyl alcohol solution were mixed in 5: The volume ratio of 1.6:4:0.7 is evenly mixed. The prepared solution is added to an acidic solution with a pH of 3 for catalysis, and the hydrogel is obtained after standing for 5 minutes, soaked in deionized water until neutral, and the finished hydrogel is obtained. Freeze-drying, scanning electron microscopy on the surface of the hydrogel (results are attached image 3 ). It can be seen from the figure that the microscopic surface of the hydrogel surface is smooth, and the fractures are relatively regular.

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Abstract

The invention discloses a hydrogel sustained-release carrier for oral drugs as well as a preparation method and an application of the hydrogel sustained-release carrier, and belongs to the technical field of pharmaceutical preparations. A homogeneous solution is obtained by mixing such raw materials as chitosan, dialdehyde starch, gelatin and polyvinyl alcohol according to proportions, and the homogeneous solution, when orally taken into a stomach, can rapidly form a gel so as to take covering and sustained-release effects on the carrier drugs; therefore, the hurt of a high-drug concentration to a receptor is relieved. The drugs, which can achieve sustained release in the stomach, is especially suitable for treating gastric diseases.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a hydrogel slow-release carrier for oral medicine, a preparation method and application thereof. Background technique [0002] Ordinary administration methods, the drug is continuously released in high concentration in the body, the maintenance time is short, and the fluctuation is large, which may easily cause the receptor sensitivity to decrease, not only fail to achieve the desired curative effect, but may also produce drug resistance and even side effects . The drug controlled release system uses certain materials as the carrier to make the drug into a certain dosage form. The drug sustained release carrier can control the release of the drug in the body, so that the drug can be slowly released in the body at a certain speed within an appropriate time according to the set dose. Release, prolong drug action time, reduce drug degradation and loss, reduce drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/42A61K47/32A61P1/00
CPCA61K9/0002A61K9/0053A61K9/06A61K47/32A61K47/36A61K47/42
Inventor 林青赵秋莹王鑫华张小娟郝凌云
Owner JINLING INST OF TECH
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