A composite bioactive coating for implants and its preparation process

A technology of biological activity and preparation technology, which is applied in the field of implant composite bioactive coatings and its preparation technology, can solve the problems of immature bioactive coatings, achieve self-healing repair, good biocompatibility, The effect of meeting the needs of clinical application

Active Publication Date: 2018-08-31
苏州九一高科无纺设备有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many types of bioactive coatings in the prior art, they also have good biocompatibility, corrosion resistance, wear resistance, excellent mechanical properties, and the ability to promote the bonding between the implant and bone tissue and bioactive coatings that promote new bone regeneration are immature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A composite bioactive coating for an implant, prepared from the following raw materials, in parts by weight: 25 parts of tricalcium phosphate, 10 parts of tetracalcium phosphate, 7 parts of nano-hydroxyapatite, and 5 parts of calcium silicate hydrate , 1 part of graphene oxide, 2 parts of polyamide, 1 part of nano-magnesium, 4 parts of strontium hydrogen phosphate, 1 part of beryllium oxide, 2 parts of gelatin, 0.5 part of lanthanum chloride, 0.2 part of lysine, 0.8 part of polyvinylpyrrolidone, 2 parts of sodium alginate, 0.1 part of silver carbonate, 1 part of sodium citrate dihydrate, 0.3 part of phosphatidylcholine, and 0.6 part of polyethylene glycol.

[0025] The size of the nano-hydroxyapatite is 30-80nm.

[0026] The preparation process of the implant composite bioactive coating comprises the following preparation steps:

[0027] Weigh according to the above parts by weight;

[0028] First add tricalcium phosphate, tetracalcium phosphate, beryllium oxide, lysi...

Embodiment 2

[0034] A composite bioactive coating for an implant, prepared from the following raw materials, in parts by weight: 38 parts of tricalcium phosphate, 18 parts of tetracalcium phosphate, 15 parts of nano-hydroxyapatite, and 12 parts of calcium silicate hydrate , 4 parts of graphene oxide, 5 parts of polyamide, 3 parts of nano-magnesium, 8 parts of strontium hydrogen phosphate, 4 parts of beryllium oxide, 6 parts of gelatin, 3 parts of lanthanum chloride, 2 parts of lysine, 2.5 parts of polyvinylpyrrolidone, 8 parts of sodium alginate, 0.6 parts of silver carbonate, 4 parts of sodium citrate dihydrate, 2 parts of phosphatidylcholine, and 2.4 parts of polyethylene glycol.

[0035] The size of the nano-hydroxyapatite is 30-80nm.

[0036] The preparation process of the implant composite bioactive coating comprises the following preparation steps:

[0037] Weigh according to the above parts by weight;

[0038] First add tricalcium phosphate, tetracalcium phosphate, beryllium oxide...

Embodiment 3

[0044] A composite bioactive coating for an implant, prepared from the following raw materials, in parts by weight: 27 parts of tricalcium phosphate, 12 parts of tetracalcium phosphate, 8 parts of nano-hydroxyapatite, and 6 parts of calcium silicate hydrate , 1.5 parts of graphene oxide, 2.8 parts of polyamide, 1.2 parts of nano-magnesium, 4.5 parts of strontium hydrogen phosphate, 1.4 parts of beryllium oxide, 2.3 parts of gelatin, 0.8 parts of lanthanum chloride, 0.4 parts of lysine, 0.9 parts of polyvinylpyrrolidone, 2.8 parts of sodium alginate, 0.2 parts of silver carbonate, 1.6 parts of sodium citrate dihydrate, 0.5 parts of phosphatidylcholine, and 0.8 parts of polyethylene glycol.

[0045] The size of the nano-hydroxyapatite is 30-80nm.

[0046] The preparation process of the implant composite bioactive coating comprises the following preparation steps:

[0047] Weigh according to the above parts by weight;

[0048] First add tricalcium phosphate, tetracalcium phosph...

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Abstract

The invention discloses an implant composite bioactive coating and a preparation process thereof. The coating is prepared from the following raw materials including tricalcium phosphate, tetracalcium phosphate, nano-hydroxyapatite, tobermorite, graphene oxide, polyamides, nano magnesium, strontium hydrogen phosphate, beryllia, gelatin, lanthanum chloride, lysine, polyvinylpyrrolidone, sodium alga acid, silver carbonate, dihydrate sodium citrate, phosphatidylcholine and polyethylene glycol. The composite bioactive coating provided by the invention has the high binding strength to a base material, and the binding force of the composite bioactive coating to the base material is high; and meanwhile, the abrasion coefficient of the composite bioactive coating to steel balls is no higher than 0.182, the abrasion resistance is good, and the comprehensive mechanical performance is excellent; and in addition, the biocompatibility is good, the composite bioactive coating has good osteoconduction, self-healing and restoring of bone tissues are prompted advantageously, the binding capacity of implants and the bone tissues and new bone regeneration are prompted, and the clinical application demands can be met.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an implant composite bioactive coating and a preparation process thereof. Background technique [0002] With the aggravation of the aging population and the increase of joint damage caused by various injuries, it often leads to changes in the joint structure. Medication alone cannot improve joint function. In addition to artificial joint surgery, the deformed joint can be fundamentally corrected. , to restore the normal function of the joint, but also through artificial joint replacement surgery. [0003] At present, artificial joints can be roughly divided into metal-based, ceramic-based and polymer-based artificial joints according to different materials, among which metal-based artificial joints are most commonly used. Titanium and its alloy materials are widely used in artificial joint repair and replacement due to their good machinability and biocompat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D11/26C25D9/04A61L27/32A61L27/06A61L27/54
CPCA61L27/06A61L27/32A61L27/54A61L2400/18A61L2430/24C25D9/04C25D11/26
Inventor 林春梅
Owner 苏州九一高科无纺设备有限公司
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