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Preparation method of MCM-41 modified carbon paste electrode and application of MCM-41 modified carbon paste electrode in electrochemical detection of ceftriaxone

A technology of MCM-41 and carbon paste electrodes, applied in the direction of material electrochemical variables, etc., can solve the problem of poor sensitivity

Inactive Publication Date: 2017-01-25
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Enterobacter cloacae, Acinetobacter spp and Pseudomonas aeruginosa have poor susceptibility to the drug

Method used

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  • Preparation method of MCM-41 modified carbon paste electrode and application of MCM-41 modified carbon paste electrode in electrochemical detection of ceftriaxone
  • Preparation method of MCM-41 modified carbon paste electrode and application of MCM-41 modified carbon paste electrode in electrochemical detection of ceftriaxone
  • Preparation method of MCM-41 modified carbon paste electrode and application of MCM-41 modified carbon paste electrode in electrochemical detection of ceftriaxone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 : Preparation of MCM-41 Mesoporous Molecular Sieve

[0012] Use ammonia water as an alkali source to adjust pH, the steps of hydrothermal synthesis are as follows (the ratio of raw materials is as follows): Weigh 1.20 g CTAB into a 100 mL three-necked flask with a balance, add 50 mL distilled water, 60 o C water bath heating, magnetic stirring until CTAB dissolves. Under stirring conditions, add 25% ammonia water to adjust the pH to 10.2. After mixing, slowly add 5 mL TEOS dropwise, and a white precipitate is gradually formed. Continue to stir for 6 hours, then take it out, filter it on a circulating water multipurpose vacuum pump, and continuously rinse with hot distilled water to obtain the original all-silicon MCM-41 molecular sieve powder. After drying at room temperature, put the obtained semi-finished product into a porcelain crucible and place it in a muffle furnace for 250 o Bake at C for 2 h, then at 600 o It is calcined at C for 4 hours, taken out, an...

Embodiment 2

[0013] Example 2 : Preparation of bare electrodes

[0014] Weigh 1.0 g of graphite powder with a balance into an agate mortar to grind. During the grinding process, proceed in one direction as much as possible. When the graphite powder is no longer a fine powder, add 5-6 drops of silicone oil. , Continue to grind, and try to grind in one direction as much as possible when grinding again. At the same time, avoid the graphite powder from being brought out of the mortar due to excessive force. When the graphite powder in the mortar is found to be in good flake shape, stop grinding, and put the ground graphite powder into a glass tube with an inner diameter of 5 mm and a length of 8 cm, compact it with a thin glass rod, and insert a copper wire , Use weighing paper to polish the other end of the electrode brightly, set aside.

Embodiment 3

[0015] Example 3 : Preparation of MCM-41 Mesoporous Molecular Sieve Modified Electrode

[0016] Use a balance to weigh 0.10 g of MCM-41 mesoporous molecular sieve white powder and 0.90 g of graphite powder in an agate mortar. After the white powder is not visible, add 6 drops of silicone oil drop by drop, mix well and continue grinding. After grinding evenly and sufficiently, put it into a glass tube and compact it with a glass rod. Cut a piece of copper wire, sand it with sandpaper to remove the dirt and oxides on the surface of the copper wire until the surface of the copper wire is bright. Wrap an insulating tape around 1cm so that it fits into one end of the glass tube. Insert the copper wire into the carbon powder. The surface of the tape and the carbon powder are the same. Pick up. After making the electrodes, label them for later use.

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Abstract

The invention relates to application of MCM-41 mesoporous molecular sieve modified carbon paste in electrochemical detection of ceftriaxone. An MCM mesoporous molecular sieve is prepared from Cetyl Trimethyl Ammonium Bromide (CTAB) serving as a template agent and tetraethoxysilane (TEOS) by a hydrothermal synthesis method, and the template agent is removed by a two-step calcining method. The MCM mesoporous molecular sieve is expressed by XRD, FT-IR and a transmission electron microscopy method. The prepared MCM mesoporous molecular sieve is doped into graphite powder to prepare a carbon paste modified electrode, and the electrochemical behavior of the ceftriaxone for an MCM-41 mesoporous molecular sieve modified carbon paste electrode mainly from the aspects of the pH value of a buffering solution the scanning speed and the like; the concentration of a ceftriaxone medicine and the relevance with an electrochemical response are examined, so that a basis is supplied to quick and quantitative detection. The MCM-41 mesoporous molecular sieve modified carbon paste electrode has wide prospect in the aspect of electrochemical detection of the ceftriaxone medicine, and a simple and convenient method is supplied to quick electrochemical detection of the ceftriaxone medicine.

Description

Technical field [0001] The invention relates to an electrochemical sensor for measuring ceftriaxone. Background technique [0002] Ceftriaxone is the third-generation cephalosporin, which is effective against Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter flurodiae, Indole-positive Proteus, Providencia and Serratia The MIC90 of the genus is between 0.12 and 0.25 mg / L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa have poor sensitivity to the drug. It has a strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis. It also has a good effect on hemolytic streptococcus and pneumococcus. The MIC for Staphylococcus aureus is 2 to 4 mg / L. Methicillin-resistant Staphylococcus and Enterococcus are resistant to this drug, and most Bacteroides fragilis are resistant to this drug. It can be seen that detecting the level of ceftriaxone in the body is of great significance for rational drug use. E...

Claims

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Application Information

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IPC IPC(8): G01N27/48G01N27/30
Inventor 田忠贞李秀珍李冬梅
Owner UNIV OF JINAN
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