Chitosan-quaternary-ammonium-salt antibacterial agent and antibacterial liquid, preparing technology of chitosan-quaternary-ammonium-salt antibacterial agent and preparing technology of chitosan-quaternary-ammonium-salt antibacterial liquid

A chitosan quaternary ammonium salt and a preparation process technology, which can be applied to local antibacterial agents, medical preparations containing active ingredients, organic active ingredients, etc. and other problems, to achieve the effect of improved antibacterial performance, good cross-linking effect and good reactivity

Active Publication Date: 2017-02-01
福建省隆丰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wang Xiaohua prepared an antibacterial finishing agent by degrading chitosan and reacting with isocyanate, but the author claimed that chitosan and isocyanate could not react homogeneously, and the synthesis failed
[0006] The current research issues are: 1. Chitosan has general antibacterial properties, and its antibacterial properties need to be improved
2. The polarity differen

Method used

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  • Chitosan-quaternary-ammonium-salt antibacterial agent and antibacterial liquid, preparing technology of chitosan-quaternary-ammonium-salt antibacterial agent and preparing technology of chitosan-quaternary-ammonium-salt antibacterial liquid

Examples

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Effect test

Embodiment 1

[0028] 1. Add methyl ethyl ketone oxime to dry methyl ethyl ketone, and then slowly drop it into isophorone diisocyanate. Preferably, the ratio of mass parts of active hydrogen and -NCO is controlled to be n(H):n(NCO)=0.55:1, and the dropwise addition temperature is controlled not to exceed 40 degrees, then slowly heated to 80 degrees, cooled, and prepared for used for subsequent reactions at room temperature. The product in this step can be referred to as product one, and its degree of reaction can be measured by the di-n-butylamine method.

[0029] 2. Add 100ml of isopropanol, 5 grams of chitosan and appropriate amount of glycidyltrimethylammonium chloride into the three-necked bottle. Preferably, the mass ratio of chitosan and glycidyltrimethylammonium chloride is controlled to be 1:3-4, the reaction temperature is 70-80 degrees, and the time is 5-8 hours, and then it can be suction filtered, Wash thoroughly with ethanol and dry. The product in this step can be referred ...

Embodiment 2

[0032] The main difference between this embodiment and Embodiment 1 is that the chitosan quaternary ammonium salt antibacterial substance is liquid, that is, the chitosan quaternary ammonium salt antibacterial liquid. The chitosan quaternary ammonium salt antibacterial liquid preparation process can be prepared as an antibacterial agent by the process of Example 1, and then according to conventional methods, such as being dissolved in water and stirring to make a liquid chitosan quaternary ammonium salt antibacterial liquid. In addition, the chitosan quaternary ammonium salt antibacterial solution can also adopt the process in Example 1, only correspondingly omitting the steps of dehydration such as drying and drying. Other similarities will not be repeated here.

Embodiment 3

[0034] This embodiment is one of the specific applications of the first embodiment. The chitosan quaternary ammonium salt antibacterial agent (abbreviated as antibacterial agent) is dissolved in water, stirred, and the antibacterial agent is soaked in a ratio of 0.1-1% of the cloth weight and a bath ratio of 7-10, dehydrated, and dried at 90 degrees. Bake at 120 degrees for 30 minutes to get chitosan quaternary ammonium antibacterial fabric (abbreviated as antibacterial fabric). The antibacterial performance test was carried out according to the FZ73023 standard, and the antibacterial rate of Escherichia coli was as follows after washing 50 times:

[0035] Sample serial number 1 2 3 Antibacterial rate 55.42 67.44 99.99

[0036] Sample 1 is chitosan and commercially available blocking isocyanate Bayer company 3100; Sample 2 is that chitosan does not carry out the quaternization of step 2, and directly chitosan grafts blocking monoisocyanate; Sample 3 is...

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Abstract

The invention discloses a preparing technology of a chitosan-quaternary-ammonium-salt antibacterial agent. The preparing technology includes the following steps that chitosan and epoxypropyltrimethylammonium chloride are prepared into chitosan quaternary ammonium salt with the substitution degree, then the chitosan quaternary ammonium salt is reacted with isocyanate closed by methyl ethyl ketoxime, and the reactive chitosan-quaternary-ammonium-salt antibacterial agent can be obtained. The invention discloses the chitosan-quaternary-ammonium-salt antibacterial agent, chitosan-quaternary-ammonium-salt antibacterial liquid and the preparing technology of the chitosan-quaternary-ammonium-salt antibacterial agent and a preparing technology of the chitosan-quaternary-ammonium-salt antibacterial liquid. Synthesized quaternary ammonium salt modified chitosan is adopted, and single-closed isocyanate is introduced on the chitosan. The antibacterial performance of the reactive quaternary-ammonium-salt chitosan is good and is far higher than that of the chitosan; the chitosan is introduced into an isocyanate reaction group, and the good reactivity is achieved; the crystallinity of the quaternary-ammonium-salt chitosan is reduced, the isocyanate can be evenly reacted with fabric, the crosslinking effect is good, and the antibacterial performance can be remarkably improved.

Description

technical field [0001] The invention relates to a chitosan antibacterial substance, in particular to a chitosan quaternary ammonium salt antibacterial substance. Background technique [0002] Chitosan is the product of deacetylation of chitin, and it is the most basic and important derivative of chitin. Chitin, also known as chitin and chitin, is chemically named (1,4)-2-acetamide-2-deoxy-β-D-glucan, and is mainly found in the shells of shrimp, crabs, pupae and insects. And in the cell walls of fungi and algae. The dry shell of arthropods contains about 20-50% chitin. There are three structures of chitin in nature: α, β, γ, among which the most common and common is the α type. The annual biosynthesis of chitin on the earth is billions of tons, and it is a natural polymer compound whose output is second only to cellulose. The structures of chitin and chitosan are as follows: [0003] [0004] In the pharmaceutical industry, surgical sutures made of chitosan have good ...

Claims

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Application Information

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IPC IPC(8): C08B37/08A61K31/722A61P31/02
CPCA61K31/722C08B37/003
Inventor 庄跃林陈江枫
Owner 福建省隆丰生物科技有限公司
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