PELCL/polycaprolactone-REDV electrospun fiber film and preparation method

A technology of electrospun fiber and caprolactone, which is applied in the field of tissue engineering and biomedical materials, can solve the problems of increasing the cost of raw materials and reducing the activity of biologically active substances, and achieves good fiber morphology, good biological activity, and promotes the development of vascular endothelial cells. Effects of Adhesion and Growth
CN106729976AInactive Publication Date: 2017-05-31TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2017-05-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a polyethylene glycol-b-poly(L-lactide-co-epsilon-caprolactone) / poly (epsilon-caprolactone)-REDV blended superfine electrospun fiber film and a preparation method thereof. Poly (epsilon-caprolactone) with low molecular weight is coupled with REDV small peptides, poly (epsilon-caprolactone)-g-REDV is prepared, poly (epsilon-caprolactone)-g-REDV and polyethylene glycol-b-poly(L-lactide-co-epsilon-caprolactone) with high molecular weight are together dissolved in a mixed solvent of chloroform and N,N-dimethyl formamide, and an electrostatic spinning method is used for preparation in order to obtain the superfine fiber film. The electrospun fiber film comprises superfine fiber whose diameter is 400-1000nm, and thickness is 50-200[mu]m. The electrospun fiber film contains REDV small peptides on the surface, in order to promote adhesion and growth functions of vascular endothelial cells; at the same time, the superfine fiber film is used for wrapping and loading nucleic acid, protein, medicament and other bioactive substances, and has capability for controlled release of bioactive substances. The product is used for biomedical materials.
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Description

technical field

[0001] The invention relates to a polyethylene glycol-b-poly(L-lactide-co-ε-caprolactone) (PELCL) / polycaprolactone-REDV electrospun ultrafine fiber membrane and its preparation method, belonging to in the field of tissue engineering and biomedical materials. Background technique

[0002] Using electrospinning technology to load bioactive substances such as gene proteins in tissue engineering scaffolds can regulate cell adhesion, proliferation and migration, and is beneficial to tissue repair and regeneration. Biodegradable polylactide copolymer polyethylene glycol-b-poly(L-lactide-co-ε-caprolactone) (PELCL), polyε-caprolactone (polycaprolactone, PCL), etc. Good biocompatibility and excellent mechanical properties. Electrospinning technology was used to prepare ultrafine fiber membranes, which simulated the structure of extracellular matrix and could be used as scaffold materials for tissue reconstruction. Arginine-glutamic acid-aspartic acid-valine (Arg-Gl...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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