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A low-pollution preparing method of glucose anisate and antibacterial applications of the glucose anisate

Anisic acid sugar ester, low pollution technology, applied in the directions of antibacterial drugs, sugar derivative preparation, chemical instruments and methods, etc., can solve the problems of unfavorable biological products, medical applications, complex reaction conditions, easy to pollute the environment, etc. The effect of less impurities, simple post-treatment and high catalytic efficiency

Inactive Publication Date: 2017-06-30
嘉兴德扬生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of method has complex and harsh reaction conditions, high energy consumption, and low yield; using concentrated acid or alkali as a catalyst will cause sugar coking, resulting in impure and colored products, and the use of toxic solvents is easy to pollute the environment and result in The products are not conducive to biological and medical applications

Method used

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  • A low-pollution preparing method of glucose anisate and antibacterial applications of the glucose anisate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Take 100 g of dried star anise fruit and grind it into 60-mesh powder, put it into a 2000 mL hard round-bottomed flask of volatile oil extractor, then add 800 mL of deionized water into the round-bottomed flask, soak for 1 h, Start to heat up to 90°C, and keep at 90°C for 2 hours, and the fennel oil enters the branch pipe of the volatile oil extractor along with part of the water vapor;

[0023] (2) Separate the fennel oil collected in the branch pipe of the volatile oil extractor to remove most of the water, then add 1 g of anhydrous magnesium sulfate to the fennel oil, let it stand for 20 min, heat the mixed solution to 50 °C, and Carry out suction filtration with Buchner funnel while hot to remove magnesium sulfate, collect filtrate, obtain fennel oil;

[0024] (3) Take 7.5 mL of fennel oil obtained in step (2), add it to a 50 mL round bottom flask, place the round bottom flask on a magnetic stirrer, and then add 1 g of ferric chloride to the round bottom flask, ...

Embodiment 2

[0031] The yields of anisic acid obtained in step (5) of Example 1 and sugar esters of anisic acid obtained in step (7) of Example 1 were calculated using formulas. The results showed that the yield of anisic acid obtained by hydrogen peroxide oxidation was as high as 91.3%, and the purity was 99.8%, and the product was white needle-like crystals; the yield of anisic acid sugar ester was 93%, and the purity was 99.5%.

Embodiment 3

[0033] Take the anisic acid sugar ester obtained in step (7) of Example 1, add sterile physiological saline to configure different concentrations of anisic acid sugar ester suspension, and incubate with Staphylococcus aureus and Escherichia coli respectively, and use plate counting method to detect Antibacterial properties of sugar anisate:

[0034]In the experiment, 0.5 mL of Staphylococcus aureus bacterial liquid was placed in a conical flask filled with 50 mL of physiological saline, and 6 groups were set up, and then sugar anisate suspensions of different concentrations (1-100 μg / mL), and then put all the triangular flasks in a constant temperature incubator, and incubate at 37 °C for 12 h, then take out the suspension and dilute a certain gradient, then plate, count, and calculate the antibacterial rate of sugar anisate. Perform the same operation with 0.5 mL of E. coli liquid containing the same number of bacteria.

[0035] The experimental results showed that differen...

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Abstract

The invention relates to a low-pollution preparing method of glucose anisate and antibacterial applications of the glucose anisate. Chinese star anise fruits are adopted as a raw material and extracted to obtain anise oil, the anise oil is oxidized to obtain anisic acid, and the glucose anisate is further prepared. According to the method, a volatile oil extractor is utilized to simply and rapidly extract the Chinese star anise fruits to obtain the anise oil so that anise oil extraction and enrichment are completed in one step. Hydrogen peroxide which is a green and efficient oxidant is adopted to prepare the anisic acid, the oxidation efficiency of the hydrogen peroxide is high, the hydrogen peroxide is environmentally friendly, and later-period purification is simple. For preparation of the glucose anisate, a solid organic synthetic process is adopted, a sulfonic acid type solid acid is adopted as a catalyst, no organic solvent is used, high-temperature high-pressure treatment is not needed, and the solid acid can be recovered and reutilized so as to reduce pollution to the environment. The prepared glucose anisate has excellent antibacterial properties.

Description

technical field [0001] The invention relates to the field of preparation and application of anise oil derivatives, in particular to a method for preparing sugar esters of anisate with low pollution and its antibacterial application. Background technique [0002] Star anise is a plant of the star anise family, which has high medicinal and edible value. The fennel oil distilled and extracted from the star anise fruit has antibacterial and antihistamine effects, and has a good beauty effect, and can be used as an industrial additive, food preservative, and polymer monomer. The main component of fennel oil is anethole, and its chemical name is p-propenyl anisole. Studies have shown that anisole in fennel has antibacterial effects, has a good inhibitory effect on Escherichia coli and Shigella, and can prevent various infectious diseases. Diarrhea, promotes healing of inflammation and ulcers. Anisic acid sugar ester is an important derivative of anise oil, which is obtained thro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H13/08C07H1/00A61P31/04A01P1/00
CPCC07H13/08C07H1/00
Inventor 羊梦诗李鑫
Owner 嘉兴德扬生物科技有限公司
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