Synthesis method of pyrrole [1, 2-a] quinoline derivative

Abstract

The invention discloses a synthesis method of a pyrrole [1, 2-a] quinoline derivative, and the method is as follows: dissolving a 3-amino cyclobutanone compound and an alpha-halogenated acetylene as starting materials in an organic solvent for reaction in the presence of an alkaline catalyst, monitoring reaction process by TLC, after the reaction, cooling to room temperature, adding saturated salt water to the reaction system, using an extraction agent for extraction until the water phase is clarified, combining organic phases, drying the organic phases with a drying agent, filtering, concentrating, and performing column chromatography to obtain the pyrrole [1, 2-a] quinoline derivative. The poly nitrogen-containing fused-heterocyclic pyrrole [1, 2-a] quinoline derivative with a highly-complex structure can be synthesized by one step without intermediate separation, the reaction raw materials are easy to obtain, and the synthesis method has the advantages of convenient operation, high product yield and more convenient synthesis process, shortens the reaction process and reduces the reaction time.

Description

technical field [0001] The invention belongs to the technical field of compound synthesis, and in particular relates to a synthesis method of pyrrolo[1,2-a]quinoline derivatives. Background technique [0002] Nitrogen-containing fused heterocyclic compounds usually have unique biological activity, low toxicity, and high systemic property, and are often used as structural units of pharmaceutical active molecules and pesticides. In addition, they also have great potential in the fields of dyes, natural product synthesis, and polymer materials. important application. Among nitrogen-containing fused heterocycles, substituted pyrrole[l,2-a]quinolines and their oxidized or reduced forms are the parent structures of many natural products or biologically active compounds, present in the biologically active natural alkaloid gephyrotoxin Among them, it is an alkaloid extracted by Daly from the secretion of a frog Dendrobates histrionics in 1977 (Helv.Chim.Acta 1974,57,2597). Studies...

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Problems solved by technology

Although great achievements have been made in the synthesis of pyrrolo[1,2-a]quinoline derivatives, many synthetic methods still have deficiencies, such as: the use of precious metal catalysts, expensive ligands, structural Complex and rare compounds are used as starting materials, the universality of the reactants is limited, the synthesis steps are cumbersome, and harsh reaction conditions such as microwave or high temperature are required, the reaction time is long, and the yield is low.

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