Quaternary ammonium salt surfactant sterilizing agent with heterocyclic structure

Abstract

The invention discloses a quaternary ammonium salt surfactant sterilizing agent with a heterocyclic structure. The name of the quaternary ammonium salt surfactant sterilizing agent is N-(2-thiazole carbamyl methyl)-N, N-dimethyl-N-alkyl ammonium chloride (alkyl chain length is 10, 12, 14 and 16). The quaternary ammonium salt surfactant sterilizing agent aims to solve the problems of high dosage ofthe conventional chemical sterilizing agent, insensitivity to Gram-negative bacteria, environment pollution and the like. The quaternary ammonium salt surfactant sterilizing agent provided by the invention has the advantages of low toxicity, easiness in degrading, low dosage, safety to human, livestock and environment. As proved by experiment, the N-(2-thiazole carbamyl methyl)-N,N-dimethyl-N-alkyl ammonium chloride can be used for restraining bacillus subtilis and escherichia coli, and is 2.1 to 40mug / mL in effective inhibitory concentration. The quaternary ammonium salt surfactant sterilizing agent is in accordance with sustainable development strategy, can be taken as a sterilizing agent for makeup, medical preparations, food preservatives, medical sterilization, biologic composites, textile, chemical industry and the like, and has a wide application prospect.

Description

technical field [0001] The invention relates to a quaternary ammonium salt surfactant bactericide containing a heterocyclic structure. Background technique [0002] There are a large number of harmful microorganisms in nature that endanger people's health, cause the decomposition, deterioration and corruption of various materials, endanger the environment and industrial and agricultural production, and cause major economic losses. The most effective way to stop harmful microorganisms is to rely on chemical agents. Quaternary ammonium fungicide is a kind of cationic compound. It has been discovered and used for nearly a century. It not only has strong bactericidal power and rapid onset, but also has low irritation to skin and tissue, and has no corrosive effect on metal and rubber products. The most commonly used quaternary ammonium fungicide is the traditional surfactant dodecyl dimethyl benzyl ammonium chloride (1227), which has a history of more than half a century. It i...

AI Technical Summary

Problems solved by technology

The most commonly used quaternary ammonium fungicide is the traditional surfactant dodecyl dimethyl benzyl ammonium chloride (1227), which has a history of more than half a century. It is a kind of excellent fungicide in terms of antibacterial properties, but its long-term use and the increasing dosage have some problems, such as serious drug resistance, insensitivity to Gram-negative bacteria, and secondary pollution to the environment

Therefore, the synthesis and development of new structure quaternary ammonium salts is also relatively fast. Among them, the introduction of five-membered and six-membered heterocyclic quaternary ammonium nitrogen, and the synthesis of double and multi-quaternary ammonium salts have attracted much attention. Handling is difficult, resulting in low yield, high cost, and difficulty in industrialization; on the other hand, although the use of double and polyquaternary ammonium salts is relatively safe to humans, the hazards to the environment still exist. Due to the complex structure more difficult to degrade in nature

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