Hemostatic antibacterial nanometer film and preparation method thereof

A hemostatic antibacterial and nano-membrane technology, which is applied in medical formula, medical science, bandages, etc., can solve problems such as high closure strength, infection, and weak closure effect, and achieve convenient and comfortable use, good biological safety, and great promotion value Effect

Active Publication Date: 2018-03-13
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Medical tape mainly includes gauze, band-aid, etc., which are the cheapest, most convenient and most widely used wound dressing materials; however, when dealing with complex wounds, the sealing effect is slightly weak
Surgical sutures have high closure strength for wounds, and recently degradable surgical sutures have been developed one after another, without the need for postoperative removal and causing trouble and pain for patients; however, professional doctors are required to operate, and secondary wound damage caused by use and infection, postoperative scars are also inev

Method used

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  • Hemostatic antibacterial nanometer film and preparation method thereof
  • Hemostatic antibacterial nanometer film and preparation method thereof
  • Hemostatic antibacterial nanometer film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The hemostatic antibacterial nanofilm provided by the present embodiment is composed of the following components by mass percentage:

[0024]

[0025] Wherein, the polymer matrix material is composed of one or more of polyurethane, polysaccharide (polysaccharide), silicone rubber, polyglycolic acid, polylactic acid, polyester; One or more components; the antibacterial factor is composed of one or more of nano-silver particles, silver ions, antibacterial peptides, and polylysine; the protective layer is composed of polyvinyl alcohol, cellulose, water-soluble One or several components of sexual polysaccharides.

[0026] The following is the preferred scheme for the preparation of the above-mentioned hemostatic antibacterial nano-film of the present embodiment, the specific circumstances are as follows:

[0027] Prepare an aqueous solution of alginic acid and chitosan, drop the obtained polysaccharide solution onto a single crystal silicon wafer, and perform spin coati...

Embodiment 2

[0029] The difference from Example 1 is that in this example, the polylactic acid is configured into a dichloromethane solution, and the obtained polylactic acid solution is added dropwise on the single crystal silicon wafer, and the parameters are: the rotation speed is 4000rpm, and the time is 30s. Spin coating to obtain a polymer matrix nanofilm accounting for 2.0% of the total mass; disperse 0.075% of the total mass of antimicrobial peptides and 0.075% of the total mass of calcium ions in water, add dropwise to the above polymer matrix nanofilm, and For: the rotation speed is 3000rpm, and the spin coating time is 10s to realize the loading of the factor; the polyvinyl alcohol aqueous solution accounting for 97.85% of the total mass is dripped onto the nano-film of the above loading factor, and the parameters are: the rotation speed is Spin coating at 6000rpm for 20s to obtain a polymer matrix nanofilm with a protective layer and a load factor. After the nano-film is dried,...

Embodiment 3

[0031] The difference from Example 1 is that in this example, polyurethane is dissolved in acetone to obtain a solution, which is dripped onto a single crystal silicon wafer, and spin-coated under the parameters: the rotation speed is 4000rpm, and the time is 30s. 1.5% polymer matrix nano-membrane; disperse 0.05% nano-silver and 0.05% calcium ions in water, add dropwise to the above polymer matrix nano-membrane, and the parameters are: the rotation speed is 3000rpm , and the time is 10s to carry out spin coating to realize the loading of the factor; the polyvinyl alcohol aqueous solution accounting for 98.4% of the total mass is dripped onto the nano-film of the above loading factor, and the parameters are: the rotation speed is 6000rpm, and the time is 20s Spin-coating is carried out under the environment to obtain a polymer matrix nano-membrane with a protective layer and a load factor. After the nano-film is dried, it is peeled off from the slide, cut into the desired shape...

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Abstract

The invention discloses a hemostatic antibacterial nanometer film and a preparation method thereof. The hemostatic antibacterial nanometer film is prepared from a polymer matrix material, a hemostaticfactor, an antibacterial factor and a protective layer. The artificially synthesized polymer is served as the matrix material, and the nanometer film with excellent mechanical property is obtained through a spin-coating method. The hemostatic factor and the antibacterial factor which are in nanoscale are loaded to the nanometer film. The protective layer is made of water-soluble polymer substance, protecting the factors and achieving release of the physiological environment environmental responsiveness. Therefore, the hemostatic antibacterial nanometer film has the advantages of high biological safety, high convenience and comfortableness in use, adaptability to wound surfaces in complex shape, good adhesion effect o soft tissue, quick hemostatic action and good antibacterial effect, canbe applied to rapid repairing of human body soft tissue, such as acute trauma such as incised wound and puncture wound, and a part of visceral injury and chronic wound caused by such as the diabetic foot.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hemostatic antibacterial nano film and a preparation method thereof. Background technique [0002] The huge market, continuous demand, and the research and development of soft tissue repair materials have always been hot spots in the field of biomedical materials. Traditional soft tissue wound repair materials mainly include medical tapes, sutures and biological glues, which have been making important contributions to human survival and health since their invention. [0003] Medical tapes mainly include gauze, band-aid, etc., which are the cheapest, most convenient and most widely used wound dressing materials; however, when dealing with complex wounds, the sealing effect is slightly weak. Surgical sutures have high closure strength to wounds, and recently degradable surgical sutures have been developed one after another, without the need for postoperative removal...

Claims

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Application Information

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IPC IPC(8): A61L15/46A61L15/44
CPCA61L15/44A61L15/46A61L2300/404A61L2300/412A61L2300/418A61L2400/04
Inventor 施雪涛宣承楷
Owner SOUTH CHINA UNIV OF TECH
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