Hemostatic antibacterial nanometer film and preparation method thereof

Abstract

The invention discloses a hemostatic antibacterial nanometer film and a preparation method thereof. The hemostatic antibacterial nanometer film is prepared from a polymer matrix material, a hemostaticfactor, an antibacterial factor and a protective layer. The artificially synthesized polymer is served as the matrix material, and the nanometer film with excellent mechanical property is obtained through a spin-coating method. The hemostatic factor and the antibacterial factor which are in nanoscale are loaded to the nanometer film. The protective layer is made of water-soluble polymer substance, protecting the factors and achieving release of the physiological environment environmental responsiveness. Therefore, the hemostatic antibacterial nanometer film has the advantages of high biological safety, high convenience and comfortableness in use, adaptability to wound surfaces in complex shape, good adhesion effect o soft tissue, quick hemostatic action and good antibacterial effect, canbe applied to rapid repairing of human body soft tissue, such as acute trauma such as incised wound and puncture wound, and a part of visceral injury and chronic wound caused by such as the diabetic foot.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hemostatic antibacterial nano film and a preparation method thereof. Background technique [0002] The huge market, continuous demand, and the research and development of soft tissue repair materials have always been hot spots in the field of biomedical materials. Traditional soft tissue wound repair materials mainly include medical tapes, sutures and biological glues, which have been making important contributions to human survival and health since their invention. [0003] Medical tapes mainly include gauze, band-aid, etc., which are the cheapest, most convenient and most widely used wound dressing materials; however, when dealing with complex wounds, the sealing effect is slightly weak. Surgical sutures have high closure strength to wounds, and recently degradable surgical sutures have been developed one after another, without the need for postoperative removal...

AI Technical Summary

Problems solved by technology

[0003] Medical tape mainly includes gauze, band-aid, etc., which are the cheapest, most convenient and most widely used wound dressing materials; however, when dealing with complex wounds, the sealing effect is slightly weak

Surgical sutures have high closure strength for wounds, and recently degradable surgical sutures have been developed one after another, without the need for postoperative removal and causing trouble and pain for patients; however, professional doctors are required to operate, and secondary wound damage caused by use and infection, postoperative scars are also inevitable

Commercial bioglues mainly include α-cyanoacrylate medical glue, which can be used for wound repair on the surface layer or sublayer of the skin. It has the advantages of fast curing speed, high strength, and convenient use; It matches the modulus of human tissue, causes wound heating when used, and the degradation product has cytotoxicity and other shortcomings, which also limit its wide application

[0004] Moreover, most of the traditional repair methods only close and stop bleeding after wound debridement, and seldom take into account the possible follow-up bacterial infection.

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