Drug-loaded static spinning guided tissue regeneration membrane preparation method and product and application thereof

A technology that guides tissue regeneration and electrospinning. It is applied in the field of nano-biomedical materials. It can solve problems such as insufficient mechanical properties, fast degradation speed, and collapse, and achieve the effects of improving mechanical properties, good crystallization, and satisfying production and application.

Inactive Publication Date: 2018-04-06
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its degradation speed is fast, it is easy to cause early collapse in the body, and its mechanical properties are insufficient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Preparation of drug-loaded HNTs

[0022] Take a certain amount of PMB, dissolve in pure water and stir for 20 minutes, then add a certain amount of HNTs solution, and disperse ultrasonically for 40 minutes, so that HNTs is fully dispersed in the PMB solution, so that the concentration ratio of HNTs and PMB is 1:2. The mixed solution of PMB and HNTs was placed in a vacuum drying oven and vacuumed at a temperature of 0.05 until no bubbles appeared on the surface of the liquid. After taking it out from the vacuum drying oven, stir for 5 minutes and then repeat vacuuming to drive out the residual air bubbles in the inner cavity of HNTs, so that more PMB can enter the inside. Centrifuge at 3000rpm to take out the supernatant for use, and wash the precipitate with ultrapure water. The drug-loaded powder was dried at 50° C. for 24 hours. Grind the dry powder with an agate mortar and filter it with a sieve for later use.

[0023] 2. Preparation of electrospun drug-loaded...

Embodiment 2

[0026] 1. Preparation of drug-loaded HNTs

[0027] Take a certain amount of PMB, dissolve in pure water and stir for 20 minutes, then add a certain amount of HNTs solution, and disperse ultrasonically for 40 minutes, so that HNTs is fully dispersed in the PMB solution, so that the concentration ratio of HNTs and PMB is 1:2. The mixed solution of PMB and HNTs was placed in a vacuum drying oven and vacuumed at a temperature of 0.05 until no bubbles appeared on the surface of the liquid. After taking it out of the vacuum drying oven, stir for 5 minutes and then repeat vacuuming to drive out the residual air bubbles in the inner cavity of HNTs, so that more PMB can enter the interior. Centrifuge at 3000rpm to take out the supernatant for use, and wash the precipitate with ultrapure water. The drug-loaded powder was dried at 50° C. for 24 hours. Grind the dry powder with an agate mortar and filter it with a sieve for later use.

[0028] 2. Preparation of Electrospun Drug-loade...

Embodiment 3

[0031] 1. Preparation of drug-loaded HNTs

[0032] Take a certain amount of PMB, dissolve in pure water and stir for 20 minutes, then add a certain amount of HNTs solution, and ultrasonically disperse for 40 minutes, so that HNTs is fully dispersed in the PMB solution, so that the concentration ratio of HNTs and PMB is 1:2. The mixed solution of PMB and HNTs was placed in a vacuum drying oven and vacuumed at a temperature of 0.05 until no bubbles appeared on the surface of the liquid. After taking it out of the vacuum drying oven, stir for 5 minutes and then repeat vacuuming to drive out the residual air bubbles in the inner cavity of HNTs, so that more PMB can enter the interior. The supernatant was taken out by centrifugation under the condition of 3000 rpm for use, and the precipitate was washed with ultrapure water. The drug-loaded powder was dried at 50° C. for 24 hours. Grind the dry powder with an agate mortar and then filter through a sieve for later use.

[0033]2...

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PUM

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Abstract

The invention relates to a drug-loaded static spinning guided tissue regeneration membrane preparation method and a product and an application thereof, and comprises preparation of drug-loaded HNTs and preparation of a static spinning drug-loaded composite nano fiber film. The method employs HNTs having a hollow structure as a drug carrier-loaded anticancer medicine, can avoid burst release phenomenon due to mixed static spinning of the simple medicine and a polymer, and the prepared static spinning guided tissue regeneration membrane has good treatment effect. The doped inorganic HNTs in thestatic spinning polymer nano fiber can increase the mechanical properties of the composite fiber membrane, and has good biological compatibility, degradability and bone growth promotion performance, and is in favor of taking the drug-loaded nano fiber as a functional tissue engineering frame material for complex internal environment; the raw material HNTs is the nano nanotube having good crystallization and low cost, which is environmentally friendly, the preparation method of the guided tissue regeneration membrane is simple, operationality is strong, and production and application can be satisfied.

Description

technical field [0001] The invention relates to a preparation method of a drug-loaded electrospinning guided tissue regeneration membrane, its product and application. Specifically, poly(racemic lactic acid-co-caprolactone) and gelatin with good biodegradability and good biocompatibility are used as matrix materials, and halloysite is used as a drug carrier to prepare a drug with Composite nanofiber membrane with antibacterial effect. The invention belongs to the field of nano biomedical materials. Background technique [0002] Defects of periodontal tissue and bone tissue are common problems in clinical practice, and guided tissue regeneration is one of the most common methods for treating bone defects. Improving the performance of guided tissue regeneration membranes and preparing new guided tissue regeneration membranes can greatly improve the effect of periodontal and bone tissue regeneration. Restoration and regeneration are of great significance. The preparation of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/02A61L27/18A61L27/50A61L27/22D01D5/00D04H1/728
CPCA61L27/02A61L27/18A61L27/222A61L27/50A61L27/54A61L2300/252A61L2300/404A61L2430/02A61L2430/12D01D5/0015D04H1/728C08L67/04
Inventor 何丹农祝闪闪周涓王萍金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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