Novel application of glycosyl modified polyphenol compounds

A polyphenolic compound and glycosyl modification technology, which is applied in the direction of effective components of hydroxyl compounds, drug combinations, anti-toxins, etc., can solve the problem that the pathogenesis of pulmonary fibrosis is not completely clear, the disease cannot be fundamentally treated, and the treatment effect is not good, etc. problems, achieve good lung protective function, good anti-oxidation effect, reduce oxidative stress and inflammatory response
CN107951871AActive Publication Date: 2018-04-24天津海润家和创新医药研究有限责任公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
天津海润家和创新医药研究有限责任公司
Publication Date
2018-04-24

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Abstract

The invention discloses an application of glycosyl modified polyphenol compounds as drugs for relieving paraquat poisoning and treating pulmonary fibrosis. The glycosyl modified polyphenol compounds have the structure shown in the description. The glycosyl modified polyphenol compounds have a good oxidation resistance function and a lung protection function and have a notable protection function on lung injury caused by paraquat, and a mechanism is related with reduction of formation of oxygen radicals, relieving of oxidative stress and inflammatory reaction, increase of content of GSH in blood serum and SOD in lung tissue and reduction of content of MDA and HYP in lung tissue. The glycosyl modified polyphenol compounds can effectively inhibit bleomycin-induced pulmonary fibrosis of mice,and the mechanism is related with reduction of expression of TGF-beta 1, IL-6, alpha-SMA, P-smad2, type I collagen and type III collagen in lung tissue, increase of content of GSH and SOD in blood serum and reduction of the content of HYP in lung tissue.
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Description

technical field

[0001] The invention belongs to the field of medicines, and in particular relates to the use of sugar-modified polyphenol compounds for treating paraquat poisoning and pulmonary fibrosis, in particular to the use of xylose-modified pyrogallic acid in preparing medicines for rescuing paraquat poisoning and treating pulmonary fibrosis application. Background technique

[0002] Paraquat, whose main component is 1,1'-dimethyl-4,4'-dichlorodipyridine, is a fast-killing herbicide with strong toxicity to humans and animals[1]. According to literature reports [2], oral administration of 7-8ml of paraquat stock solution at a concentration of 20% can cause death, and the mortality rate is as high as 60%-88%, and most of the survivors have acute lung injury and pulmonary interstitial fibrosis , the prognosis is poor. In addition, paraquat poisoning can also damage organs such as the heart, liver, kidney, adrenal gland, central nervous system, skeletal muscle, and sple...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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