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Surface-modified porous-tantalum biological material and preparation method thereof

A biological material and surface modification technology, which is applied in the field of surface modified porous tantalum biomaterials and its preparation, can solve problems such as limited, uncontrollable, and uncontrollable pore size, and achieve good connectivity, enhanced stability, and improved biocompatibility sexual effect

Inactive Publication Date: 2018-05-08
吕莉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a surface modified porous tantalum bio- Materials and their preparation methods

Method used

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  • Surface-modified porous-tantalum biological material and preparation method thereof

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example 1

[0025] Take a tantalum sheet with a diameter of 10mm and a thickness of 0.3mm, polish it with silicon carbide sandpaper until the surface is smooth, and then use acetone, ethanol, and deionized water to clean it ultrasonically for 10 minutes. After washing, put it in a drying oven and dry it at 50°C. 2h, to obtain pretreated tantalum sheet, take 10mL of 40% hydrogen fluoride solution by mass fraction, 40mL of 98% sulfuric acid solution by mass fraction, and mix them evenly to obtain corrosion solution. Take 10g of corrosion solution, 400g of ethylene glycol, add 400g of deionized water, and Stir at 300r / min for 10 hours to obtain the electrolyte, soak the pretreated tantalum sheet in the corrosion solution for 1 second, take it out and wash it with deionized water until the washing solution is neutral, then use the tantalum sheet as the anode and the platinum sheet as the cathode, soak in In the electrolyte and energized, the current density is controlled to 50mA / cm 2 After ox...

example 2

[0027] Take a tantalum sheet with a diameter of 13mm and a thickness of 0.4mm, polish it with silicon carbide sandpaper until the surface is smooth, and then use acetone, ethanol, and deionized water to clean it ultrasonically for 13 minutes. After washing, place it in a drying oven and dry it at 55°C. 2h, to obtain pretreated tantalum sheet, take 15mL of 40% hydrogen fluoride solution by mass fraction, 60mL of 98% sulfuric acid solution by mass fraction, and mix them evenly to obtain corrosion solution. Take 15g of corrosion solution, 600g of ethylene glycol, add 600g of deionized water, and Stir at 350r / min for 13 hours to obtain the electrolyte, soak the pretreated tantalum sheet in the corrosion solution for 2s, take it out and wash it with deionized water until the washing solution is neutral, then use the tantalum sheet as the anode and the platinum sheet as the cathode, soak in In the electrolyte and energized, the current density is controlled to 75mA / cm 2 After oxidiz...

example 3

[0029]Take a tantalum sheet with a diameter of 15mm and a thickness of 0.5mm, polish it with silicon carbide sandpaper until the surface is smooth, and then use acetone, ethanol, and deionized water to clean it ultrasonically for 15 minutes. After washing, place it in a drying oven and dry it at 60°C. 3h, to obtain the pretreated tantalum sheet, take 20mL mass fraction of 40% hydrogen fluoride solution, 80mL mass fraction of 98% sulfuric acid solution, mix well to obtain corrosion solution, take 20g corrosion solution, 800g ethylene glycol, add 800g deionized water, Stir at 400r / min for 15 hours to obtain the electrolyte, soak the pretreated tantalum sheet in the corrosion solution for 3s, take it out and wash it with deionized water until the washing solution is neutral, then use the tantalum sheet as the anode and the platinum sheet as the cathode, soak in In the electrolyte and energized, the current density is controlled to 100mA / cm 2 After oxidizing for 60 minutes, take i...

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Abstract

The invention relates to a surface-modified porous-tantalum biological material and a preparation method thereof, and belongs to the technical field of biological medical materials. The surface-modified porous-tantalum biological material and the preparation method have the beneficial effects that an electrochemical anodic oxidation technology is adopted for modifying the surface of a tantalum sheet to prepare a porous tantalum-pentoxide layer with a micro-nano-scale three-dimensional through porous structure, the pore-diameter size can be controlled, the distribution and the communication ofpores are good, and a hydroxyapatite layer is further constructed on the surface of an oxidation layer, so that protein absorption and cell diffusion and proliferation are obviously enhanced, the biocompatibility and the osteoconduction are improved, the microenvironment beneficial to cell growth is generated, the adhesion, the proliferation, the differentiation and the mineralization of primary osteoblasts of human are promoted, the growth of bone tissues into the porous tantalum is promoted to form a unique bone-implant interface, the stability and the function of the implant in the bone tissues are obviously enhanced, the osseointegration of the bone-implant interface is accelerated, and the stability of the implant into the bone tissues is obviously enhanced. The surface-modified porous-tantalum biological material has the advantages of high corrosion resistance and bright application prospect.

Description

technical field [0001] The invention relates to a surface-modified porous tantalum biomaterial and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] Biomedical metal materials are a kind of biomedical materials with metal or alloy as the matrix, also known as surgical metal materials or medical metal materials, which belong to biologically inert materials. They are used for diagnosis, treatment and replacement of damaged tissues and organs Or materials that enhance its function. Common medical metal materials mainly include the following categories: stainless steel, cobalt-based alloys, titanium alloys, etc. Compared with traditional metal materials, ceramic materials, polymer materials, etc., biomedical materials have not been developed for a long time, and people are still relatively unfamiliar with them, but the research on biomedical materials is of great significance to human health. [0003] The corr...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/32A61L27/50A61L27/56C25D11/26
CPCA61L27/047A61L27/32A61L27/50A61L27/56A61L2400/18A61L2420/02A61L2430/02C25D11/26
Inventor 徐炜王文新史玉玲
Owner 吕莉
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