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Preparation method of strontium-doped tantalum oxide nanorod structure bioactive coating

A tantalum oxide, bioactive technology, applied in the preparation of strontium-doped tantalum oxide nanorod structure bioactive coatings, the preparation of bioactive coatings on the surface of tantalum-based medical implants, can solve the problem of not being able to obtain nanofibers Form and other problems, to achieve the effect of promoting adhesion and proliferation, process stability, and simple ingredients

Active Publication Date: 2020-11-24
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing sol-gel, anodic oxidation, alkali heat treatment, biomimetic mineralization, plasma spraying, magnetron sputtering and other technologies can modify the surface of tantalum metal, but none of them can obtain nanofiber morphology on the surface of tantalum metal.

Method used

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  • Preparation method of strontium-doped tantalum oxide nanorod structure bioactive coating
  • Preparation method of strontium-doped tantalum oxide nanorod structure bioactive coating
  • Preparation method of strontium-doped tantalum oxide nanorod structure bioactive coating

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preparation example Construction

[0028] A method for preparing a strontium-doped tantalum oxide nanorod structure bioactive coating, comprising the following steps:

[0029] 1) Primary hydrothermal treatment of tantalum:

[0030] Mix 0.1~0.6mol / L HF solution, 0.1~0.4mol / L HNO 3 Solution, 1~4mol / L H 2 o 2 Two or three compound aqueous solutions in the solution are made into a hydrothermal solution, injected into a hydrothermal reaction kettle, the filling degree of the solution is 10% to 40%, and the tantalum sample is soaked in the solution. Under the hydrothermal treatment for 1 to 24 hours, a tantalum oxide nanorod structure coating can be obtained on the surface of the tantalum base, that is, the treated tantalum sample is obtained;

[0031] 2) Secondary hydrothermal treatment of tantalum oxide nanorod structure coating:

[0032] One of the strontium acetate solution with a concentration of 0.001-0.6mol / L, the strontium nitrate solution with a concentration of 0.001-0.6mol / L and the strontium hydroxide...

Embodiment 1

[0036] With 0.4mol / L HF and 2mol / L H 2 o 2 Prepare a hydrothermal solution with a molar concentration of 240°C for 24 hours, inject it into a hydrothermal reaction kettle, and the filling degree of the solution is 40%, soak the tantalum sample in the solution, and treat it under the condition of 240°C for 24 hours, and the surface of the tantalum base can be A tantalum oxide nanorod structure coating is obtained, the microstructure of the coating is in the shape of upright nanorods, and the diameter of the nanorods is about 20 nanometers;

[0037]Inject the strontium acetate solution with a concentration of 0.05mol / L into the hydrothermal reaction kettle, the solution filling degree is 40%, and soak the tantalum-based sample covered with the tantalum oxide nanorod structure coating into the strontium acetate solution, at 200 The strontium-doped tantalum oxide nanorod structure coating can be obtained on the tantalum surface by hydrothermal treatment for 2 hours under the cond...

Embodiment 2

[0039] With 0.4mol / L HF and 2mol / L H 2 o 2 Prepare a hydrothermal solution with a molar concentration of 240°C for 24 hours, inject it into a hydrothermal reaction kettle, and the filling degree of the solution is 40%, soak the tantalum sample in the solution, and treat it under the condition of 240°C for 24 hours, and the surface of the tantalum base can be A tantalum oxide nanorod structure coating is obtained, the microstructure of the coating is in the shape of upright nanorods, the diameter of the nanorods is about 20 nanometers, the length of the nanorods is about 150-200 nanometers, and the roughness Ra is about 107.1±4.6 nanometers;

[0040] Inject the strontium acetate solution with a concentration of 0.1mol / L into the hydrothermal reaction kettle, the solution filling degree is 40%, and soak the tantalum-based sample covered with the tantalum oxide nanorod structure coating into the strontium acetate solution, at 200 The strontium-doped tantalum oxide nanorod struct...

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Abstract

The invention discloses a preparation process of a tantalum surface strontium doped tantalum oxide nanorod structure bioactive coating. Firstly, an aqueous solution containing hydrofluoric acid, nitric acid and hydrogen peroxide is taken as a hydro-thermal solution, a tantalum matrix is subjected to hydro-thermal treatment under different hydro-thermal conditions, then the obtained tantalum oxidenanorod structure coating is subjected to hydro-thermal treatment again under the strontium-containing hydro-thermal environment condition, a microstructure of the obtained coating takes the shape ofa nanorod, the physical phase is tantalum pentoxide, the strontium element is doped in the nanorod structure coating, the bonding strength between the strontium doped nanorod structure coating and thematrix is high, the surface roughness of the obtained coating is relatively small, the precipitation of the strontium element from the coating shows the rule that the strontium element is precipitated fast firstly and then precipitated slowly, bone apatite is rapidly induced to be formed in the body-fluid-like environment, and the coating is excellent in bioactivity.

Description

technical field [0001] The invention belongs to the technical field of bioactivation modification of medical metal surfaces, and relates to a preparation technology of a bioactive coating on the surface of a tantalum-based medical implant, in particular to a preparation of a strontium-doped tantalum oxide nanorod structure bioactive coating method. Background technique [0002] When tantalum metal is placed in the atmosphere, tantalum oxide (Ta 2 o 5 ) film, tantalum oxide (Ta 2 o 5 ) The existence of the film will make it have excellent corrosion resistance, keep stable in a wide range of pH values, and long-term placement in salty liquids (such as blood) will not damage this layer of oxide film. In addition, after tantalum metal is implanted into the human body, biological tissues are easy to grow on its surface, so tantalum is also known as "biophilic metal" and has good biocompatibility. Compared with the existing medical metal materials, the excellent corrosion res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/30A61L27/50C23C22/34C23C22/64
CPCA61L27/047A61L27/306A61L27/50A61L2420/02A61L2420/06A61L2430/02C23C22/34C23C22/64
Inventor 王翠翠殷海荣郭宏伟乔荫颇马振辉白建光李明阳高杨
Owner SHAANXI UNIV OF SCI & TECH
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